Sivaneswari Thiga’s Post

Happy Monday! How about starting your week with findings from the article below.

Please join the IMAG/MSM WG on Multiscale Modeling and Viral Pandemics and GLIMPRINT, Thursday, October 17th at 3 pm Eastern Daylight Time (EDT) for: Quenching Small-Amplitude Limit Cycle Oscillations for Predictive Modeling of Complex Molecular Mechanisms Underlying Chemical and Biochemical Oscillatory Reactions. Insights into the Effects of Ethanol on the Hypothalamic-Pituitary-Adrenal (HPA) Axis Dynamics Vladana Vukojevic, Karolinska Institute Quenching Small-Amplitude Limit Cycle Oscillations, i.e., Quenching Analysis (QA), is a method specifically designed to take the advantage of the oscillatory dynamics that emerges in the vicinity of a supercritical Hopf bifurcation and harvest it to acquire unique quantitative information about the investigated system that can easily be compared with model predictions. To this aim, QA relies on a series of controlled additions of a compound that is inherent to the system or reacts with a reactive species in the system, to immediately, yet temporarily suppress the oscillations. For each species, QA yields two values, the quenching concentration (qi), i.e., the amount of species i needed, and the quenching phase (ji), i.e., the phase angle with respect to a reference point in an oscillation, at which this amount is to be added to temporarily pause the oscillations. By comparing the experimentally derived quenching concentrations and quenching phases with results obtained from mechanistic models, one can determine whether key reaction pathways are correctly identified and incorporated in the model of the reaction mechanism and assess how realistically the model reflects the true mechanism of the investigated system. The aim of this presentation is twofold: to present the theoretical background behind QA and to demonstrate the potential of this method for understanding specific features of a complex neuroendocrine dynamical system, the Hypothalamic-Pituitary-Adrenal (HPA) axis, under normal physiology and response to ethanol-induced stress. For more information see: 1)  Čupić Ž, Stanojević A, Marković VM, Kolar-Anić L, Terenius L, Vukojević V. The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations. Addict. Biol. 2017 22(6):1486-1500. doi: 10.1111/adb.12409 2) Stanojević A, Marković VM, Čupić Ž, Kolar-Anić Lj, Vukojević V. Advances in mathematical modelling of the hypothalamic–pituitary–adrenal (HPA) axis dynamics and the neuroendocrine response to stress. Current Opinion in Chemical Engineering 2018, 21:84–95. doi:10.1016/j.coche.2018.04.003 Register at: https://lnkd.in/grPyacr5 #Pituitary, #medicine, #thalamus, #therapy, #dynamicalsystems,, #mathematicalbiology, #computationalbiology, #signaling, #phaseresetting,  #IMAGMSM, #MathematicalBiology, #SystemsBiology, #Biology, #Medicine, #Technology,, #MSMViral, #IUB, #Glimprint, #Biocomplexity, #Methodologies, #Biotechnology, #Karolinska, #LimitCycles

Register for the webinar below to learn more about the latest in hereditary cancer testing application!

Inviting you to read our latest article

Super excited to share this webinar on October 16 that I helped produce. Please register and share; it will be a great discussion for #pathologists, #oncologists, #specialists and #lab directors. Hear experts from #pathology and #clinical leadership with Solaris Health and Integrated Medical Professionals, PLLC discuss the evolution of guideline-based Hereditary Cancer Testing, bringing testing in-house to improve surgical decisions and therapeutic guidance of #PARP inhibitors. This webinar is urology focused on #prostate and #castration-resistant cases but applies to patients with #breastcancer, #ovariancancer, #colorectalcancer and #pancreaticcancer. #oncology #precisionmedicine #guidelines #genetictesting #bettercare

📢 In case you missed it! Don't forget to check out MedNews Week's most recent Keynote Speaker, 🌟Dr. Ann LaCasce🌟 of the Dana-Farber Cancer Institute – as she discusses the latest updates in Hodgkin's Lymphoma. It was a pleasure to learn from her! Event link:  https://lnkd.in/gCYkxiAf Accomplishments:  🌎Internationally Recognized leader in Hematological Malignancies and Treatment 👨🔬director of the advanced fellowship in Hematologic Malignancies  🏆recipient of multiple prestigious awards such as: -Regional Top Doctor in Castle Connolly  -medical Oncology education Award of DFCI -Institutional citizenship award at DFCI 🎓passionate mentor to students in all levels of training Yan Leyfman, MD Maduri Balasubramanian Sean Jackewicz Shreevikaa Kannan Soumiya Nadar Rabab Hunaid Abbas Emad Bin Zahid Ahmed Hashim Azeez Vallabhaneni Sree Harshitha Muskan Joshi  Helena Sanchez Coloma Alexandra Van de Kieft Harshal C. Gayathri Pramil Menon Fabiha Amin Adhith Theyver #HodgkinLymphoma #HodgkinDisease #HodgkinCancer #HodgkinAwareness #HodgkinWarrior #HodgkinFight #HodgkinStrong #BeatHodgkin #LymphomaAwareness #CancerSurvivor  #Lymphoma #LymphomaAwareness  #BloodCancer #CancerAwareness  #FightLymphoma #LymphomaSupport #LymphomaWarrior #BeatLymphoma #CancerSurvivor #CancerResearch #Hematology #Hematologist #BloodDisorders #BloodResearch #BloodHealth #HematologyAwareness #HematologyEducation #BloodScience #HematologyConference #HematologyNews #cancer #cancersucks #cancermemes #cancersurvivor #cancerawareness #cancerousmemes #cancerous #cancerresearch #cancerfree #cancerfighter #cancerwarrior #cancermeme #cancersupport #cancerprevention #cancersurvivors #cancers #cancercare #cancerresearchuk #cancerawarenessmonth #oncology #immunology #immunotherapy #genetherapy #cancer #cancerawareness #cancerresearch #oncologist #oncología #oncologyresearch #clinicaltrial #clinicalresearch #oncology #immunology #immunotherapy #genetherapy #cancer #cancerawareness #cancerresearch #medicine #research 

🙌 Thanks, Chadi Nabhan, MD, MBA,FACP. It was great to reconnect personally (reflecting on our Northwestern University - The Feinberg School of Medicine days/times together), and thematically for this #HemOnc Pulse podcast with 2 great colleagues talking about the genesis, journey, and destiny of our global #HoLISTIC consortium (https://lnkd.in/e_wP65ZD). 👉 There is MUCH more to come with the dynamic data-driven decision models we are creating that span the lifelong time horizon for patients to personalize cancer care based on individual patient/disease/imaging/treatment factors, with a special emphasis on the estimation of post-acute and late effects that occur years & decades after completion of #cancer therapy. #decisionsupport #decisionmaking #predictivemodeling #prognostication #cancerresearch #cancercare #personalizedmedicine #personalizedcare #survivorship #bigdata #multisourcedata #machinelearning #artificialintelligence #HodgkinLymphomaInternationaStudyforIndividualCare

Catch the replay from MedNews Week’s latest Keynote Speaker - Dr. Brian Van Tine of Washington University in St. Louis, MO, Department of Medicine - as he discusses Translating Metabolic Therapies into Sarcoma! EVENT LINK:- https://lnkd.in/g2zC5uR2 🏆Accomplishments: 👨🔬Director, Developmental Therapeutics (Phase 1) Sarcoma Program, Alvin J 🏆Internationally recognized leader in Sarcoma Research and Treatment 🏆Recipient of Various awards and honors, including but not limited to: Presented the 2014 Rosenfeld Lecture for the Sarcoma Alliance for Research and Collaboration First Place Poster, “Loss of Taspase1 Abrogates HER2/neu Induced Breast Cancer, ”Breast Cancer Symposium, Washington University Physician Scientist Training Program, Washington University 🎓A passionate and dedicated mentor who has mentored >12 mentees in all stages of training. #SarcomaAwareness #SarcomaSupport #BoneCancer #SoftTissueSarcoma #CancerAwareness #FightSarcoma #CureSarcoma #SarcomaWarrior #SarcomaResearch #RareCancer #SarcomaCommunity #SarcomaSurvivor #SarcomaStrong #EndSarcoma #CancerResearch #SarcomaWarrior #ChildhoodCancer #SarcomaFighter #SarcomaSupportGroup #TogetherAgainstSarcoma #MetabolicTherapy #MetabolicHealth #NutritionalTherapy #KetogenicDiet #IntermittentFasting #MetabolicSyndrome #Biohacking #MitochondrialHealth #MetabolicFlexibility #FastingForHealth #LowCarbLiving #HighFatDiet #MetabolismBoost #NutritionalScience #TherapeuticFasting #NutritionalMetabolism #EnergyMetabolism #NutritionAndHealth #CellularHealth #MetabolicBalance #MetabolicTherapiesForSarcoma #SarcomaMetabolism #MetabolicApproachToSarcoma #SarcomaNutritionalTherapy #MetabolicInterventionsForSarcoma #SarcomaAndKetogenicDiet #MetabolicTreatmentForSarcoma #SarcomaMetabolicHealth #NutritionalStrategiesForSarcoma #SarcomaMetabolicSyndrome #MetabolicSupportForSarcoma #SarcomaAndIntermittentFasting #MetabolicTherapeuticApproach #SarcomaMetabolicFlexibility #MetabolicApproachToCancer #SarcomaBiohacking #MetabolicStrategiesForSarcoma #SarcomaMitochondrialHealth #MetabolicBalanceForSarcoma #SarcomaAndNutritionalMetabolism

𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐚 𝐍𝐞𝐰 𝐒𝐞𝐠𝐦𝐞𝐧𝐭 𝐚𝐭 𝐀𝐓𝐢𝐎 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝟐𝟎𝟐𝟒: 𝐓𝐡𝐞 𝐀𝐓𝐢𝐎 𝐓𝐡𝐢𝐧𝐤 𝐓𝐚𝐧𝐤 - 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐂𝐚𝐬𝐞𝐬! We're thrilled to announce an innovative segment of the ATiO Conference 2024, "The ATiO Think Tank: Clinical Cases", focusing on the dynamic field of musculoskeletal care. This unique platform is designed to foster multidisciplinary dialogue, spotlight current challenges, and explore innovative solutions in musculoskeletal health. 𝐖𝐡𝐚𝐭 𝐭𝐨 𝐄𝐱𝐩𝐞𝐜𝐭: ·   𝐄𝐱𝐩𝐞𝐫𝐭-𝐋𝐞𝐝 𝐃𝐢𝐬𝐜𝐮𝐬𝐬𝐢𝐨𝐧𝐬: Participate in one of six expert-led groups, each tackling pressing issues in musculoskeletal care through the lens of intriguing clinical cases. These groups will delve into areas such as Arthroplasty, Traumatology, Tendon and Cartilage Regeneration, Infection, and Osteoarthritis. ·   𝐈𝐧𝐭𝐞𝐫𝐚𝐜𝐭𝐢𝐯𝐞 𝐅𝐨𝐫𝐦𝐚𝐭: Each group will present up to two clinical cases illustrating critical challenges and unmet needs in the field. Discussions will explore current treatment paradigms, emerging innovations, and future aspirations for musculoskeletal care. ·   𝐃𝐞𝐞𝐩 𝐃𝐢𝐯𝐞 𝐢𝐧𝐭𝐨 𝐂𝐚𝐬𝐞𝐬: Spend a minimum of 20 minutes per case, dissecting the current situation, discussing emerging solutions, and envisioning future goals. This structured dialogue ensures a comprehensive exploration of each case from multiple perspectives. 𝐄𝐱𝐩𝐞𝐫𝐭 𝐅𝐚𝐜𝐢𝐥𝐢𝐭𝐚𝐭𝐨𝐫𝐬: ·   𝐆𝐫𝐨𝐮𝐩 𝐀 - 𝐀𝐫𝐭𝐡𝐫𝐨𝐩𝐥𝐚𝐬𝐭𝐲: with Prof. Dr. Carsten Perka, focusing on bone and muscle regeneration. ·   𝐆𝐫𝐨𝐮𝐩 𝐁 - 𝐓𝐫𝐚𝐮𝐦𝐚𝐭𝐨𝐥𝐨𝐠𝐲: with Prof. Dr. Ulrich Stöckle, delving into advanced trauma care. ·   𝐆𝐫𝐨𝐮𝐩 𝐂 - 𝐓𝐞𝐧𝐝𝐨𝐧 𝐑𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧: with Prof. Dr. Dr. Volker Alt, exploring the frontiers of tendon healing. ·   𝐆𝐫𝐨𝐮𝐩 𝐃 - 𝐂𝐚𝐫𝐭𝐢𝐥𝐚𝐠𝐞 𝐑𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧: with Prof. Elizaveta Kon, investigating innovative cartilage repair strategies. ·   𝐆𝐫𝐨𝐮𝐩 𝐄 - 𝐈𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐧: with Prof. Rihard Trebse, tackling challenges in infection management. ·   𝐆𝐫𝐨𝐮𝐩 𝐅 - 𝐎𝐬𝐭𝐞𝐨𝐚𝐫𝐭𝐡𝐫𝐢𝐭𝐢𝐬: with Prof. David Hunter, focusing on cutting-edge osteoarthritis treatments. 𝐂𝐚𝐥𝐥 𝐭𝐨 𝐀𝐜𝐭𝐢𝐨𝐧: Choose your group in advance through your ATiO account to ensure a focused and enriching discussion tailored to your expertise and interests. More information on that will follow soon via our conference organisation team. Your insights and discussions will contribute to a collective effort to shape the future of musculoskeletal care. A dedicated note-taker in each group will document the discussions, ensuring that the collective wisdom and innovative ideas generated will influence the field long after the conference concludes. Find out more about our schedule here: https://lnkd.in/eUS6rE4H #ATiOCon24 #ATiOFoundation #ATiOAlliance #ATiO #AdvancedTherapies #Orthopaedics

A CRISPR Workflow to Increase Efficacy of CAR-T Engineering and Screening Potent synthetic single guide RNAs (sgRNAs) are critical for functional gene characterization in primary cell models. This is because primary cells are more sensitive and resistant to CRISPR genome engineering than immortalized cancer cell lines. Tune in to our upcoming webinar (March 26, 11 a.m. ET) to gain insight in engineering CD8+ chimeric antigen receptor (CAR) T cells. Register here. https://lnkd.in/gFSkF229 #revvity #biolegend #crispr