Skye Bioscience Inc.’s Post

One more year presenting my research at the Internal Medicine Science days of Erasmus MC! These days are always a great way to catch up with all the different research lines within the department and of course meet new people! Here I talked about my developments in disease modelling using Kidney Organoids and how they can be a great model to better understand (rare)disease mechanisms. We'll be back next year with more! #KidneyOrganoids #InternalMedicine #iPSC #DiseaseModels #PhD #ErasmusMC

Periodontal disease, a common oral affliction, is known not only for impacting oral health but also for its strong links to systemic diseases. In a collaborative effort, Director Physician Song Zhongchen from the Ninth People's Hospital and Professor Wang Gang from Ruijin Hospital, affiliated with the Shanghai Jiao Tong University School of Medicine, recently published significant research. Their study, "Subgingival microbiome and gingival crevicular fluid metabolome characteristics in patients with Alzheimer's disease and amnestic mild cognitive impairment," appeared in the journal "Alzheimer's Research & Therapy" (impact factor 9.0). The research highlights the distinct microbiome and metabolome profiles in patients, suggesting potential diagnostic applications for these conditions. Congratulations on this groundbreaking work! For more @ https://lnkd.in/gfvWK8Mm #SJTUResearch

Coronary Microvascular Dysfunction is not just important in INOCA - take a look at the many other Cardiovascular Diseases where CMD also plays an important role! https://lnkd.in/eshAGzPp World Heart Federation Jagat Narula MD PhD Andrea Vassalotti Sean Taylor Anna HASSANI Tamara Krcmar Aude Lemoine André Translational Medicine Academy (TMA) François Christory British Heart Foundation #INOCA #coronaryMicrovascularDysfunction #heartdisease

What a program. The list of speakers alone should have you lining up to register.

🎉 Exciting news! Jun Yoshioka, MD, PhD, a molecular biologist at CUNY School of Medicine, was awarded over $3.1 million from the National Heart, Lung, and Blood Institute to delve into the role that an ancient family of proteins may have in heart disease. His focus? Investigating the scaffold protein Arrdc4 and its impact on coronary artery disease and diabetic cardiomyopathy. Dr. Yoshioka aims to understand how Arrdc4 regulates glucose uptake in stressed hearts to pioneer targets for new treatments. “Once we better understand the mechanics of Arrdc4, we can develop interventions that could allow it to ease up on, or stop altogether, its braking mechanism,” explained Dr. Yoshioka. “Doing so could help us prevent, cure, or limit damage from heart disease.” We are rooting for you, Dr. Yoshioka! 💪 Read more about it here: https://lnkd.in/eHGJK9-Z #CUNYMedicine #HeartDisease #HeartHealth

Women account for a staggering 80% of all autoimmune disease cases. But why? 🤔 A new culprit has emerged in the pursuit of understanding this medical mystery: a molecular coating typically found on half of a woman’s X chromosomes might be provoking unwanted immune responses. Montserrat Anguera, PhD, associate professor of biomedical sciences, spoke to Here & Now about new findings that shed light on the role the X chromosome plays in autoimmune disease and offer insight into future research avenues. 🧬💡 #PennVet #ResearchAtPennVet #AutoimmuneDisease

🔬 Investigating HO-1 Regulation: Insights from BACH1 Knockout Mice in Sepsis Raghavan Pillai Raju, from the Medical College of Georgia at Augusta University, USA, shared compelling findings at Redox Medicine 2024. His research explores how HO-1 regulation is altered in BACH1 knockout mice during sepsis, providing crucial insights into the complex interplay of oxidative stress and immune responses. #HO1Regulation #SepsisResearch #RedoxMedicine

New Biomarker Test for Alzheimer’s Disease Recent research at Stanford Medicine has shed light on why women are more prone to autoimmune diseases. Scientists discovered that a process known as X-chromosome inactivation, which prevents overproduction of proteins in female cells, inadvertently triggers immune responses that can lead to autoimmune conditions. By studying male mice engineered to express the Xist molecule, involved in this inactivation, the researchers found that these mice showed increased autoimmune responses, mirroring those seen in females. This breakthrough provides important insights into the gender disparity observed in autoimmune diseases and opens new paths for diagnostics and treatments. Swissmed Health is at the cutting edge of integrating groundbreaking discoveries into clinical practice. By leveraging our 30-year experience as well as the latest research, we have a very good track record delivering successful results to those who suffer from autoimmune diseases This commitment to embracing new scientific insights ensures that Swissmed Health remains a leader in delivering personalized and advanced healthcare solutions. You can learn more about this study and its importance at: https://lnkd.in/ga3FSMy9 📞+357 25010200 #swissmedicalclinics #swissmedical #medical #swissmedicine #medicine #longevity #goodhealth #healthylifestyle #wellness #health #healthconditions #treatment #MedicalNews

🗓SEMINAR: Join us on Friday, April 5th for the SCEHSC Seminar Series with Cathrine Hoyo, PhD. In her talk, Hoyo will discuss challenges we face investigating early exposure to chemical and non-chemical stressors, and their effects on metabolic dysfunction and other common chronic diseases, and how DNA methylation of sequence regions regulating the monoallelic expression of imprinted genes, some of which may be associated with obesity, can address some of the challenges we face. She will also discuss the new Illumina Human Imprintome Methylation Array together with new imprinted genes, and how this could accelerate discovery of chemical and non-chemical stress-responsive epigenetic response, genome-wide, and with that, guide public health intervention efforts for common chronic diseases. Hoyo is an epidemiologist and Professor in the Department of Biological Sciences at North Carolina State University, and co-leader of the Integrative Health Science Facility Core in the Center for Human Health and the Environment. Her research has the overarching goal of improving our understanding of how early development influences risk of common chronic diseases, especially those that exhibit racial/ethnic differences in incidence and/or mortality, including cardiometabolic diseases and some cancers. Learn more and register: https://lnkd.in/gbXK7rCr

A nested case-control study in China showed "Biomarkers evolved in a temporal sequence over 20 years in people who developed #Alzheimers disease." "Over a median follow-up of 19.9 years, cerebrospinal fluid (CSF) and imaging biomarkers changed in a specific order, with differences seen in people who subsequently were diagnosed with sporadic #AlzheimersDisease and people who remained cognitively normal." Learn More in the New England Journal of Medicine https://lnkd.in/ewEWmWXH Biomarker Changes during 20 Years Preceding Alzheimer’s Disease List of authors. - Jianping Jia, Yuye Ning, Meilin Chen, Furu Liang, Zhengluan Liao, Shan Wang, et al. Xuanwu Hospital Capital Medical University ACCOMPANYING EDITORIAL: Alzheimer’s Disease Biomarkers — Timing Is Everything - Richard Mayeux, M.D. Columbia University https://lnkd.in/ePSsTEJ2