Smart Immune’s Post

We are now at a stage in #Medicine where everything will advance very rapidly. #Bioinformatics take most of the blame. Novel #drugtargets for #atrialfibrillation and #heartfailure Insights from #metabolomics and #proteomics new paper in BioSpringbok GenomicMed with Amand Floriaan Schmidt and team

Our co-founder and CSO Jan Kubicek had the opportunity to share some insights at Discovery on Target 2024 about one of the biggest challenges in membrane protein research: stabilization. In our talk, we discussed how next-generation NativeMP copolymers are paving the way for more efficient stabilization of membrane proteins into native nanodiscs, preserving their natural environment and functionality. If you’re working in biotherapeutics or are interested in membrane protein research, this approach could be a game changer! Check out the full talk here: https://lnkd.in/eKZ8ngFM

Missed the #CRISPRgate event? Learn how its innovative dual-sgRNA approach boosts #geneediting efficiency and consistency. Perfect for tackling tough targets in #genetic research. Watch now for expert insights and practical applications! → With Twist Bioscience https://buff.ly/3XAd9nA

Cannot believe we’re already talking about SynBioBeta! Mark your calendars and come on by to discuss all things microbes, sequencing, databases, and of course enzyme discovery and engineering!

Data Deep Dive: Glanzmann thrombasthenia (GT) is a severe bleeding disorder characterized by a defect in platelet aggregation. Preclinical data published in #NatureCVR suggests our lead asset, HMB-001, in the presence of FVIIa, reduces time to platelet aggregation; achieves maximal aggregation; and does not drive aggregation in the absence of FVIIa, supporting its potential as a prophylactic solution for #GlanzmannThrombasthenia. Read the paper here: https://lnkd.in/eV4Qv-up #Data #Biotech #RareBleeding

📢 New White Paper Alert! Check out how Microcarrier-based #iPSC expansion can be made better through denovoMATRIX beadMATRIX+ and Vertical-Wheel Bioreactors, providing: 📍 Enhanced Cell Production: beadMATRIX+ #microcarrier-assisted iPSC expansion in Vertical-Wheel Bioreactors produced a larger number of high-quality cells compared to traditional aggregate culture methods. 📍 Optimized Cultivation: The process optimization, particularly the agitation rate, created an ideal culture environment for iPSC proliferation, adaptable to various downstream processes. 📍 Scalable and Consistent: The method was successfully scaled from 0.1 L to 3 L, maintaining cell viability, pluripotency, genetic integrity, and differentiation potential, supporting the development of iPSC-derived therapies. Download the white paper here: https://lnkd.in/emZdw6r9

Check out our latest "Spotlight - Start-up" feature! Today, Christian Lautenschläger and I are diving into the groundbreaking world of Nomic Bio and their game-changing technology nELISA, set to disrupt the ELISA market. #investment #research #elisa #proteomics #multiplexing

The Metagenomics Market is on the verge of explosive growth, projected to hit a staggering $9.3 billion by 2033! As we unravel the mysteries of microbial communities, we’re unlocking game-changing breakthroughs in diagnostics, therapeutics, and environmental monitoring. Fueled by cutting-edge tech, massive R&D investments, and a growing awareness of the power of microbiomes in health and disease, this market is set to reshape the future. Want to know what’s driving this incredible momentum? Dive into the full report and discover the key trends, innovations, and opportunities that will shape the future of healthcare—and beyond! Get ahead of the curve with our latest blog mentioned in the comment section! #genomics #genetics #dna #biotechnology #research #genome #health #precisionmedicine #healthcare #dnagenetics #genetictesting #BIS

I am pleased to announce the successful isolation of a #phagelysate from enriched wastewater, showing lytic activity against 11 different #clinical strains of #Klebsiella pneumoniae. This achievement marks a significant advancement in addressing #antibiotic-resistant bacteria. Looking ahead, my focus is on developing a #phagecocktail to amplify this capability. Through phage therapy, I aim to enhance effectiveness against these strains, potentially transforming treatment options. Stay tuned for further updates on this promising research journey! #PhageTherapy #AntibioticResistance #MicrobiologyResearch #Biotechnology #ScienceInnovation

Fresh out of the oven！👏 ▶ Title: RapidAIM 2.0: a high-throughput assay to study functional response of human gut microbiome to xenobiotics  🔍 Our gut microbiome has its own functionalities which can be modulated by various xenobiotic and biotic components. The development and application of a high-throughput functional screening approach of individual gut microbiomes accelerates drug discovery and our understanding of microbiome-drug interactions. The authors previously developed the rapid assay of individual microbiome (#RapidAIM), which combined an optimized culturing model with metaproteomics to study gut microbiome responses to #xenobiotics. In this study, they aim to incorporate automation and multiplexing techniques into RapidAIM to develop a high-throughput protocol. 🏷 Keywords: #Gutmicrobiome,  #metaproteomics,  #highthroughput #invitro assay, #biobanking, #functionalresponses 📰 View: https://lnkd.in/gsWCJrrH ✏ Authors: Leyuan Li, Janice Mayne, Adrian Beltran, Xu Zhang，  Zhibin Ning, Daniel Figeys