Stanford Healthcare Innovation Lab’s Post

This #BrainAwarenessWeek, we focus on the significance of research in advancing our understanding of neurodegenerative diseases. A key tool in this quest is the use of induced pluripotent stem cells (iPSCs), coupled with CRISPR-Cas9 genome editing technology. Together, they offer a powerful platform for disease modeling, functional genomic studies, and the exploration of regenerative therapy strategies. Neurodegenerative conditions such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD) collectively impact millions worldwide, with PD being notably the fastest-growing neurological disorder. These diseases are primarily characterized by the progressive loss of neurons, for example, the dopaminergic neurons in the substantia nigra in PD. A major challenge in this research field has been the limited availability of human diseased tissue for detailed examination, which has historically restricted our ability to study these conditions effectively. At iXCells we're addressing this gap through the development of iPSC-based models, including neurons derived from iPSCs. These models provide a more accurate representation of human neurological diseases by generating patient-specific differentiated cell types. This method bridges the divide between traditional animal models and human clinical research, offering a closer approximation to the human condition and thereby enhancing the potential for breakthroughs in therapy and understanding. As we mark Brain Awareness Week, we underscore the critical role of iPSC and disease modeling in neurodegenerative research. Our work aims to deepen the scientific community's comprehension of these complex conditions and to open new avenues for treatment. Discover how our application of iPSC technology is advancing the fight against neurodegenerative diseases. For more information, please visit https://lnkd.in/gHV-h6is #BrainAwarenessWeek #iPSC #NeurodegenerativeDiseases #Research #Innovation #NeurodegenerativeResearch #geneediting #crispr #cnsdiseases #pd #ALS #Parkinsons #diseasemodeling #drugdiscovery

If you love spatial biology and learning about macrophage activation in the lungs, then this paper is for you! If you are looking to be involved in this research, Alessandro Venosa, PharmD, PhD is hiring! "Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosis":

My two-year postdoc work finally online. In this manuscript, we highlighted three things: 1. lineage-specific remodeling is real 2. HDACi MOAs 3. Integration of multi-omics is powerful (proteomics, phospho-proteomics, transcriptomics, histone modifications) https://lnkd.in/gHV2FPnr

🌟 Exciting News Alert! 🌟 I am thrilled to announce the publication of my PhD project "VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates". Key Highlights of our Paper: 🔍 Unveiling the significance of VCF1 in facilitating the recognition of ubiquitylated p97-UFD1-NPL4 substrates. 🔍 Biophysical characterization of VCF1, providing unprecedented insights into its structural and functional attributes. 🔍 Exploring the dynamic interactions within the p97/VCP complex and its implications in cellular proteostasis. A big thanks to the great team involved: Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca López Méndez, Dimitris Typas, @Johannes van den Boom, Bente Benedict, Ivo Hendriks, Michael Lund Nielsen, @Hemmo Meyer, @Julien P. Duxin, Guillermo Montoya and Niels Mailand 🔗 Link to the Paper: https://lnkd.in/d3jC42jS 💡 #Research #CellBiology #ProteinDegradation #Biomedicine #Science #Innovation #ResearchPaper #p97VCP #Ubiquitylation

Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. The scientists used cell-type-specific in-vivo biotinylation of proteins (CIBOP) coupled with mass spectrometry to obtain native-state PV-IN proteomes. PV-IN proteomic signatures include high metabolic and translational activity, with over-representation of AD-risk and cognitive resilience-related proteins p/b Yale School of Medicine, Emory University School of Medicine, Emory University, Georgia Institute of Technology, Yale University, Annie M Goettemoeller, Claudia Espinosa-Garcia, Ali Tfaily, Ruth Nelson, Aditya Natu, Eric Dammer,  Juliet Santiago, PhD, Sneha Malepati, Hailian Xiao, Nicholas Seyfried, Levi Wood, Srikant Rangaraju #alzheimers #proteomics #translationalresearch https://bit.ly/4aNz0vu

Greetings to all, I am delighted to share my first post on this platform, and would like to start by highlighting our recently published article in the ACS Chemical Neuroscience journal. This work delves into the critical issue of amyloid-β peptide aggregation, a pivotal process implicated in the pathogenesis of Alzheimer’s disease, one of the most devastating neurodegenerative disorders of our time. In this study, we explored the therapeutic potential of a novel caffeine-pincered molecular receptor. Our findings demonstrate its significant capability to inhibit the self-assembly of amyloid-β peptides, a process central to the formation of toxic aggregates in the brain. Additionally, the research showcases the receptor's effectiveness in disassembling pre-existing amyloid fibrils through various non-covalent interactions. This innovative approach not only underscores the promise of targeting amyloid-β aggregation as a strategy for Alzheimer’s intervention but also highlights the potential of caffeine-pincered molecular receptor in therapeutic development. We are excited about the implications of these findings and look forward to further advancing this line of research. For those interested in exploring this study in greater detail, please access the full article via, https://lnkd.in/gkS97tAq

I am quite happy to announce that my first paper in my PhD has now been published and is publicly available for all to read (https://lnkd.in/dzAGcQUx) I would like to express my gratitude to all the co-authors for excellent collaboration and to my friend and colleague Joshua Philipp Entrop for his excellent help on the validation part! #Research #PhD #MedicalScience #HodgkinLymphoma #PersonalizedMedicine #PredictionOfStuff

Exciting News for Our Institute!  I am proud to announce that Prof. Dr. Igor G. Bondarenko, Senior Researcher at the Medical Institute for Nutrition Science and Technology, has co-authored a groundbreaking article that has been published in the prestigious Journal of Orthomolecular Medicine. 🏆 The article, titled “Targeting the Mitochondrial Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol,” is a collaborative effort with international experts and marks a significant milestone in our ongoing research at the institute. This publication not only highlights the innovative work being done in orthomolecular medicine but also strengthens our position in the global scientific community. 🌍 We are incredibly proud of Prof. Dr. Bondarenko and his contribution to this important field of study. This success reflects our commitment to advancing medical research and pushing the boundaries of what’s possible. You can read more about this achievement and access the full article here: https://lnkd.in/gP5PRDgn #research #orthomolecularmedicine #cancerresearch #publication #teamwork #innovation #medicalscience #proudmoment

Have you ever wondered how cells decide when to live and when to die? The intricate dance of life and death within our bodies is governed by various forms of cell death, with ferroptosis being a relatively recent discovery. This regulated process, characterized by iron-dependent lipid peroxidation, is not just a biological curiosity but holds the key to understanding and potentially treating a range of diseases, from cancer to neurodegeneration. Recent research, as highlighted in a Nature Cell Biology review, sheds light on the molecular ecosystem regulating ferroptosis. Before this study, the field faced significant challenges, such as understanding the diverse mechanisms that trigger ferroptosis and how cells defend against it. The complexity of ferroptosis, with its implications for disease and therapeutic strategies, was a puzzle with many missing pieces. This comprehensive review not only maps out the current landscape of ferroptosis research but also charts a course for future exploration. It delves into the roles of heterogeneity and plasticity in ferroptosis, the integrated antioxidant and membrane systems' role in sensitivity regulation, and the therapeutic prospects across a broad spectrum of diseases. As we stand on the brink of new medical breakthroughs, it's crucial to stay informed and engaged with the latest scientific advancements. Let's dive into the molecular intricacies of ferroptosis and explore its vast potential together. `#ScienceResearch #CellBiology #Ferroptosis #MedicalResearch #CancerTherapy #Neurodegeneration #BiomedicalScience #NatureCellBiology #InnovativeTherapies #HealthcareInnovation`

🌟 Thrilled to announce the release of our latest manuscript, where I am honored to be a co-first author! Our manuscript, “The unfolded protein response regulates ER exit sites via SNRPB-dependent RNA splicing and contributes to bone development,” explores the link between splicing, ER-proteostasis, and bone development. We uncover the Sm-ring components as novel players in the proteostasis network, providing new insights into the pathophysiology of Cerebro-Costo-Mandibular Syndrome (CCMS). This work wouldn’t have been possible without the dedication and collaboration of our amazing team. Check out our manuscript! 📚🔬 #Research #Science #MolecularBiology #Proteostasis #RNAsplicing #ERbiology #BoneDevelopment #CCMS #NewPublication