The Structural Genomics Consortium (SGC)’s Post

Degenerative retinal diseases, characterised by photoreceptor loss are a significant cause of global visual impairment. However, there are few treatment options available for these diseases. We are excited to share a recent study using our TRC research chemicals to identify a therapeutic small molecule via phenotypic screening. The study demonstrates efficacy in preclinical disease models, providing promising proof-of-concept results. Learn more about the study published in the International Journal of Molecular Science: https://okt.to/RJP9gj #ProductCitation #ResearchChemicals #ScienceforaSaferWorld

Source: Analytical chemistry This study presents a new method for the direct identification of microRNAs (miRNAs) using mass spectrometry analysis. The method utilizes a narrow constant-inner-diameter emitter and achieves high sensitivity and reproducibility for miRNA detection. The researchers were able to accurately quantify both spiked and endogenous miRNAs, making it a promising platform for sensitive and accurate miRNA analysis. The method also has the potential for analyzing other small oligonucleotides and facilitating disease diagnosis.

Want to learn how to standardize variant interpretation? Join Labroots at the 2024 Precision Medicine Virtual Event for the panel presentation titled, “Mitigating Variability in Somatic Variant Interpretation with Live Q&A” on May 15 at 10:30 AM PDT. In this live panel discussion, experts in NGS testing and clinical informatics will explore the issues surrounding the standardization of variant interpretation and consider how interpretation guidelines and clinical decision support (CDS) software can help to mitigate variability between laboratories. Register now to learn more: https://buff.ly/3TYPbjU #LRprecisionmed

🔔 Only a few weeks left to get early bird discount. This is the place to be, to learn about #Cell and #genetherapy and how existing technology can be applied to solve for a rare genetic disease. If you have an interest or asset in #CysticFibrosis, #bronchiectasis, #PCD, Idiopathic Pulmonary Fibrosis (IPF) and Progressive Pulmonary Fibrosis (PPF) or other rare respiratory diseases, then join us on 1st October at The Francis Crick Institute. 💊 This event is for #biotech, #pharma and #investors with an interest in #rare and #orphandrugs across the continuum of development from #pipeline to #market launch. Network with leaders in #genomics, #translational medicine, #peadiatric respiratory research.

I’m excited to share the work led by Dr Nadhir Yousfi and Prof. Laurent MESNARD, to which I had the privilege of contributing. In this letter to the journal Blood, we show how nanopore sequencing can enable fast genomic testing in cases of adult thrombotic microangiopathies. We describe 18 prospective cases to illustrate the benefits of this approach: ⏱️ Rapid turn-around time: Time to genomic results reduced from the standard 3–8 weeks to less than 3 days. 🧬 Clinical-grade analytical performance: Comparable to standard-of-care short-read sequencing, and in addition, detects highly complex structural variants of complement factor H-related genes (!!). 💊 Clinical impact: Timely, targeted treatment with complement blockade might improve patient outcomes. 💵 Cost-efficiency: Faster diagnostics could also reduce healthcare costs by minimizing unnecessary treatments. This is a great example of the benefits of integrating innovative AND accessible genomic workflows into routine clinical practice, particularly in nephrology and critical care. Read the full publication here: https://lnkd.in/exCKPDWz #Genomics #PrecisionMedicine #ThromboticMicroangiopathy #TMA #NanoporeSequencing #Nephrogenomics #ONT

Genetic studies, double-blind, placebo-controlled human clinical trials, and many studies on cells have been performed with ASEA REDOX Cell Signaling Supplement at universities and other facilities with reputable labs and multiple PhDs on staff. Many MDs, PhDs, scientists, and medical professionals have researched and studied ASEA and have been outspoken in their support, endorsement, and praise. Here are just a few. #CellSignaling #CellularHealth #PreventiveLifestyle

The integration of multi-omics approaches into mainstream diagnostic practice holds enormous clinical utility, particularly in regard to rapid disease diagnosis. We strongly support such collaborative studies between bioinformaticians and clinicians. #clinicaltrial #clinical #bioinformatics #cro #diagnosis #omics #research

A spoonful of science: Glyco-PASEF method developed for high sensitivity, high throughput glycoproteome analysis. Check out a new glyco-PASEF method in Bruker Daltonics' latest application note. Just when we thought we were sweet enough, this method, developed on the #timsTOF Pro and paired with our Aurora Ultimate CSI column, offers precise glycoproteomic analysis. It's based on original work by Mukherjee and Jankevics et al. in Prof. Albert Heck's lab at the Utrecht University and improves the sequencing of glycopeptides - providing faster and more accurate results. It's a valuable tool for advancing glycoproteomic research and understanding the role of glycoproteins in health and disease. #glycoproteomics Bruker

Dive into the realm of aging and age-related disease treatment with Steve England, SVP, in vitro Biology at Evotec! In this on-demand webinar, gain valuable insights into the latest advancements in therapeutic drug discovery and development, as we explore potential interventions to mitigate the aging process. Watch the webinar here, and access the full webinar series on aging: https://hubs.ly/Q02v_P020 #researchneverstops

🧬 Dive deep into the world of #genetherapy with Paul Batty on the #EAHAD Academy! Unveil the mechanisms of adeno-associated viral (AAV) vectors in treating #haemophilia. From understanding AAV vectors to tackling immune reactions in clinical trials, this module sheds light on the forefront of medical science. 🎥 Ready to explore? https://lnkd.in/eQ6N49r3