Sultan Ullah’s Post

Exciting #opportunity for mass spec experts.

The Methoxy Magic: Exciting progress in #HDAC11-selective inhibitors! This study from #Harvard Medical School introduces #PB94, a potent and selective HDAC11 inhibitor with promising drug-like properties. Unlike previous #inhibitors, PB94 is designed for effective blood-brain barrier penetration, a critical factor in neurological disorders. They conducted thorough pharmacokinetic/pharmacodynamic studies, PET imaging, and explored neuroinflammatory effects and therapeutic potential in neuropathic pain models. These findings open avenues for developing PB94 as a therapeutic agent for CNS-related disorders and advancing brain-permeable HDAC11-selective inhibitors. #DrugDiscovery #Neuroscience #Innovation #medchem2min link:https://lnkd.in/eyiRmVtf

target-based vs. phenotypic-based drug discovery It seems that phenotypic-based drug discovery is still in the lead. https://lnkd.in/eir75xiD #drugdiscovery #pharma #assays #pharmaceuticals #phenotypic #targetbased

Discover the current global state of vaccines against infectious diseases, including the technology being used and sector leaders, with this concise report from Nature Drug Discovery. doi: https://lnkd.in/exAGyuhH #vaccines #sarscov2 #covid19 #drugdiscovery #research #medicinalchemistry

"The discovery of #AZD4747", "Potency is sacrificed for CNS exposure."  Researchers from #AstraZeneca revealed their KRASG12C inhibitor with improved CNS exposure. The article discusses the discovery of AZD4747, which is a potent and selective inhibitor of the #KRASG12C protein. #Researchers used the strategy of removing the essential #pyrimidine ring from the structure of the compound to make it smaller and more lipophilic, following the #Lipinki rule of 5 for CNS #drugs. This modification led to a CNS penetrating compound with decent potency. In animal studies, it showed promising CNS availability. These results support the notion that compound AZD4747 could be a valuable candidate for treating patients with #CNS #metastases. https://lnkd.in/e6faviYY #jmc #chemistry #medicinalchemistry #drugdevelopment #drugdiscovery #research #synthesis #braincancer

I asked #chatgpt to explain these thoughts of mine. “We are entering the era of complete automation, where ideas and creativity will be the only most valuable assets” This is what #chatgpt explained: In the coming era of complete #automation, technological advancements will allow machines and systems to perform various tasks and processes without human intervention. This automation will streamline many aspects of our lives, making repetitive tasks more efficient and freeing up time for more creative pursuits. In this automated world, the value of traditional manual labor will decrease, while the importance of #innovative ideas and #creativity will soar. Having a unique and creative idea will become highly prized because it will be the driving force behind new inventions, solutions, and advancements. Imagine a scenario where you come up with an original #idea for a product or service. In the era of complete automation, you wouldn't need to worry about the manual labor of building or producing it. Instead, you could feed your idea into automated systems, which would handle the entire process of implementation or creation. This transition to automation emphasizes the significance of human ingenuity. It encourages people to focus on #ideation and #innovation, leveraging their creativity to improve and shape the world around them. Consequently, in this future, those who possess a knack for generating novel ideas and thinking outside the box will have a significant advantage in various fields and industries. #ai #aiautomation #drugdiscovery #research #chemistry

Modifications at positions C3 and C17 of the #steroids have consistently shown intriguing results. In this study, a novel approach is revealed to treat castration-resistant prostate #cancer. The approach involves degrading the #androgen receptor protein (AR) and inhibiting the #CYP17A1 enzyme responsible for androgen synthesis with a compound called #YXG158. In this study, the authors conducted further optimization of compound (6), originally derived from galeterone (5), resulting in the development of YXG-158 (23-h). YXG-158 (23-h), emerged as a promising #bifunctional AR #degrader and CYP17A1 inhibitor to treat #enzalutamide-resistant CRPC. YXG-158 displayed potent AR degradation and moderate CYP17A1 inhibition in vitro, along with significant antiproliferative activity in cancer cells. Importantly, 23-h did not inhibit #hERG and showed favorable #pharmacokinetic profiles in rats. In animal studies, it effectively blocked the androgen/AR signaling pathway, demonstrating its potential as a treatment option for #CRPC. https://lnkd.in/eDzCfWuY #drugdiscovery #drugdesign #medicinalchemistry #research #chemistry #pharmaceuticals

The direct conversion of inactivated #sp3 #alcohols into #oxetanes. Oxetanes are special types of molecules with unique properties that have led to important progress in medicinal chemistry. However, making these molecules in the lab is still quite difficult, which limits their use in real-life applications. In this research paper, the scientists came up with a new way to make oxetanes from regular alcohol molecules. This new method is versatile and can be used in late-stage chemical modifications. They used this approach to create a synthetic steroid derivative, which previously required at least four different steps to make. Now, with this new method, they can make it in just one step. This is exciting because it opens up possibilities for easier and faster production of important compounds in the field of medicine and drug development. https://lnkd.in/eYCbnyP9 #synthesis #chemistry #medicinalchemistry #drugdiscovery #pharmaceuticals