The Botnar Institute of Immune Engineering (BIIE) is launching as an independent research institute in Basel/Switzerland with a mission to develop novel immune-based diagnostics and therapeutics and address gaps in advanced healthcare technologies, thus improving the health of children and young people around the globe. More: https://lnkd.in/dmY3unF9
Swiss Biotech Association’s Post
More Relevant Posts
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Bone growth is regulated by a complex network of biological signaling pathways. To develop medicines for skeletal dysplasias and growth-related conditions, our research over the past two decades has been driven by a fundamental understanding of which pathway to target by leveraging one of the body’s own natural processes – and we’ve validated our approach through extensive preclinical and clinical studies. Learn more about our scientific approach: https://bit.ly/4cvb5lf
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The review explores the potential of surface bio-engineered polymeric nanoparticles (PNPs) in biomedicine, highlighting their transformative role in diagnostics, therapies, and drug delivery. Challenges include precise control over modifications, stability in biological environments, and scalability issues. Breakthroughs in biofunctionalized PNPs for applications like biosensing and targeted therapeutics are discussed. The paper addresses bonding mechanisms, stability, and efficacy in disease detection. It concludes with recommendations to overcome challenges and accelerate clinical translation. Read more details: https://lnkd.in/eMstr7T4 #polymerscience
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Need differentiated cells on your iPSC patient specific lines? Or do you have a unique line that poorly differentiates with your own protocol and you need help? If you face such challenges let Trailhead assist - this is one way where the power of HD-DoE can help. #ipsc #pluripotent #stemcell #drugdiscovery #trailbio #hddoe #cellmanufacturing #biomanufacturing #qbd #designofexperiments
At Trailhead Biosystems, we understand that groundbreaking research demands more than just off-the-shelf cell products. Our team of expert scientists can help turn your iPSC lines into your desired cell type through our proprietary protocols. Our customized solutions are designed to meet your unique needs, including... ✅ Higher purity for disease modeling ✅ Improved functionality for drug screening ✅ Large-scale production for regenerative medicine applications With state-of-the-art facilities and an unwavering commitment to quality, we ensure the reliable generation of the desired cell types, empowering you to unlock new avenues in your research. Explore our differentiation services to learn more about our tailored offerings and how we can support your pioneering work in disease modeling, drug discovery, and regenerative medicine. https://lnkd.in/gkEbXXtA #trailhead #trailbio #ipsc #stemcell #differentiation #ipscdifferentiation #diseasemodeling #production #manufacturing #solution #research
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Medical Physics Ph.D. Radiation Sciences Department, Radiation Biology Research Center, Tarbiat Modares university.
In this short movie, you can clearly observe the microstreaming flow around the microbubbles. I invite you to watch and listen carefully. 🎤Presenter: Professor Ayache Bouakaz ⏱️In Scientific session Non-ionising radiation: Ultrasound-mediated drug delivery Title: Recent advances in ultrasound-mediated drug delivery: Insights from preclinical and clinical trials. #MicrostreamingFlow #Microbubbles #UltrasoundMechanics #DrugDelivery #ScientificSession #UltrasoundResearch #ClinicalTrials
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During #AACR2024 we've heard a lot of discussions on #proteindegraders and their significant potential to expand the druggable space. Understanding the intricate interplay between these degraders, their target proteins, and the ubiquitin-proteasome system is essential to identify novel targets and to optimize drug efficacy and safety. See how deep discovery #proteomics can rapidly elucidate these mechanisms and accelerate the development of #PROTACs and #molecularglues: https://lnkd.in/gBbuXAMU
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Characterisation of #tuberculosis on Nanopore !!! Why to culture??
This week the World Health Organization consolidated its guidelines on #tuberculosis characterisation specifically highlighting three methods — including AmPORE-TB developed by Oxford Nanopore Technologies & Quadram Institute that could replace culture-based phenotypic drug susceptibility testing. In July 2023, we announced the partnership with the Quadram Institute to develop a rapid sequencing-based test (AmPORE-TB) to meet the class-based performance criteria to detect drug resistance after TB diagnosis, with the potential to guide clinical decision-making, in the future. Read more: https://bit.ly/4aqy2oQ #WorldTBDay
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Interesting perspectives from the L.E.K. team on the future of advanced therapies and implications for their bioprocessing and development
A New Generation of Drug Therapies Requires New Business Strategies
hbr.org
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We're pleased to share our involvement in the Eurostar’s Multichip project “Multiplex, Automated, and Rapid Laboratory Diagnostics for Autoimmune Diseases,” funded by the Service public de Wallonie and co-funded by the European Union and aimed at transferring the auto-immune antigen biomarker portfolio from D-tek immunodot sticks to Delta Diagnostics multiplex biosensing platform 🔬 At CER, our role in this project includes: -Reformulating these antigens to eliminate chemical “parasite” molecules that interfere with functionalization reactions, -Modifying the physiochemical and structural properties of the antigen to modulate their reactivity and conformation, -Performing bioconjugations with appropriate linkers While reformulation and conjugation are typically straightforward at milligram/gram quantities, this project challenged us to work at the microgram level. Thanks to the innovative procedures developed at #CERGroupe, we successfully achieved microscale reformulation and conjugation from as little as 10 µg of protein! Additionally, we've developed an assay to determine the degree of functionalization at the microscale. But the challenge doesn't stop here. We're committed to advancing our micro-functionalization platform, enhancing our techniques, and expanding our capabilities to meet the needs of future projects and applications with our partners Delta Diagnostics, D-Tek s.a. , Maastricht UMC+. Stay tuned for more updates as we continue to push the boundaries of bioproduction! 🚀 #Research #Innovation #Bioproduction #Eurostars #AutoimmuneDiseases #RDD #Science #CERGroupe #Microfuntionalization #Microscale #Conjugation #Protein #Bioconjugation
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Intrigued by AVITHRAPID's WP8 (Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung)? Let's dive into the details! 🔬 #DrugDiscovery is a complex puzzle, but AVITHRAPID has assembled a powerhouse team. Our experts in molecular modeling, structural biology, and beyond are collaborating to develop groundbreaking antiviral treatments. 💥 Want to know more about how we're revolutionizing antiviral drug development? Stay tuned for more updates! #AVITHRAPID #antiviral #drugdevelopment #biotech #pharma #innovation #healthcare
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Last week, we explored cutting-edge innovations with the scientific community and discussed how technological advances are transforming research to develop novel therapeutics at the SLAS (Society for Laboratory Automation and Screening) annual conference. #SLAS2024 #innovation #drugdevelopment
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