Sysmex Nordic’s Post

Howell-jolly bodies 🩸The Howell-jolly bodies are round, purple inclusions in Erythrocyte that represent DNA fragments that were part of the nucleus of immature red cells. 🩸Usually only one inclusion is present per cell, and because the spleen normally removes them, Howell-jolly bodies are not typically visible on peripheral blood smears. 🔬Associated Diseases state and conditions 1. Hyposplenism 2. Severe hemolytic Anemia 3. Megaloblastic anemia #hematology, #medicallaboratoryscience, #bloodbank

Discover the latest data on #PV! 🙌 Visit poster P1073 during the #EHA2024 poster session on June 14th to learn about prevalence of Polycythemia Vera, cytoreductive treatment, and thromboembolic events in affected patients based on a study on longitudinal German health claims data. https://lnkd.in/d8N3ujfm #Novartis #Hematology

➡️ Laboratory Features of Megaloblastic anemia: ➖️➖️➖️➖️➖️➖️➖️➖️ CBC & Peripheral Blood Smear There may be a pancytopenia (decreased RBC, WBC and platelets count). Oval macrocytes, hypersegmanted neutrophils and Howell-jolly bodies are the characteristic triad of abnormalities in megaloblastic anemia ✅️1. Red Blood Cells (RBCs) Macrocytosis: RBCs are usually larger than normal. Macrocytic and oval (egg shaped macro-ovalocyte) is diagnostic feature. Most macrocytes lack the central pallor. Anisopoikilocytosis: Marked variation in shape and size of the red cells. Ovalocytes, tear-drop cells and some fragmaneted cells are usually found. Inclusions: Howell-jolly bodies, Cabot rings and basophilic stippling may be seen. ✅️ 2. White Blood Cells (WBCs) Leukopenia: decreased WBC count. Hypersegmented neutrophils (Right shift): When there are at least 5 five-lobed neutrophils per 100 WBCs or at least 1 six-lobed neutrophil is noted. ✅️ 3. Platelets Platelet count is usually reduced. Giant platelets may also be observed. ✅️ 4. Reticulocyte Count The reticulocyte count is normal or low. ✅️ 5. Bone Marrow Examination - Cellularity: Moderately to markedly hypercellular. - M:E ratio: Due to marked erythroid hyperplasia, M:E ratio is reversed ranging from 1:1 to 1:6 (normal 2:1 to 4:1). #gaber_notes #Hematology #iron #bone_marrow #megaloblastic_anemia

➬ 𝐇𝐄𝐌𝐀𝐓𝐎𝐋𝐎𝐆𝐘 || A LEARNING GUIDE .. ✜ 𝐂𝐎𝐍𝐓𝐄𝐍𝐓: - Introduction 𝟏. Physiologic Features of the Body. 𝟐. Overview of Blood. 𝟑. Red Blood Cells. 𝟒. Disorders of Red Blood Cells. 𝟓. White Blood Cells. 𝟔. Disorders of White Blood Cells. 𝟕. Platelets and Hemorrhagic Disorders. 𝟖. Hematology Tests. . . #Hematology #RBC #CBC #hematology #microscopic #laboratory #CBC #CompleteBloodCount #Histograms #parasites #blood #BookRecommmendation #ContinuousLearning

ASH invites nominations, including self-nominations, for individuals to serve on the following guideline panels: 🩸Hydroxyurea Dosing & Monitoring for #SickleCell 🩸Treatment of AL #Amyloidosis 🩸#IronDeficiency #Anemia 🩸Immune Thrombocytopenia 🩸Myelofibrosis Submit nominations by June 10: https://ow.ly/BUkv50RIgWt #hematology

Flow immunophenotyping can help diagnose primary myelofibrosis and differentiate between essential thrombocythemia and polycythemia vera. Read more: https://brnw.ch/21wJyuM #RareDisease #Hematology 📚Clinical Cytometry

#MRCPI exam journey Day 22 #Hematology #MyelomaMultiple vs #Waldenstrom For the exam - An elederly patient with back pain, hypercalciuria think of #Myeloma. Dx: serum protein electrophoresis: increased IgG Kappa or Lambda light chains M spike does not mean IgM Bone marrow: >10 % plasma cells. Urine: Bence Jonce proteinuria. Smear test: Rouleaux appearance. - A patient with headaches, blurred vision, tinnitus ( hyper viscosity syndrome) +/- Raynaud Syndrome think of #Waldenstrom. Increased IgM

Understanding RBC shapes is crucial in diagnosing hematological disorders, as each shape provides essential insights into underlying pathologies. This image acts as a valuable reference for identifying these diverse forms #RBC #hematology #medicalreference

Pathology is the study of diseases, focusing on their causes, development, and effects on the body. It plays a crucial role in diagnosing illnesses through the examination of tissues, organs, bodily fluids, and autopsies. There are several branches of pathology, such as: - #Anatomic pathology: Examines structural changes in tissues and organs, often through biopsies. - #Clinical pathology: Focuses on laboratory tests (blood, urine, etc.) to diagnose disease. - #Forensic pathology: Investigates causes of death, often in legal cases. - #Molecular pathology: Studies disease at a genetic level. #iPathLab #Pathology iPathLab.com

🧠 #ClinicalChallenge #hematology #MedEd All of the following statements about bleeding complications in Ehlers-Danlos syndromes are true, except: A. Bleeding history may include epistaxis, muscle hematoma, menorrhagia B. Bleeding is limited to individuals with a specific Ehlers-Danlos subtype C. Tests of platelet and clotting function are normal D. Life-threatening bleeding may occur 👇Please add your answer to the comments below.