T3Ddy - Pediatric 3D technology’s Post

🎉 Excited to announce the publication of the result of my labs' 3+ years of work in IEEE Transactions on Biomedical Engineering! 🎉 https://lnkd.in/gRK6DBiC We tackled a 20-year-old challenge in cardiac MRI—unreliable and threshold-based fibrosis/scar quantification methods, particularly for left atrial fibrosis analysis from 3D LGE MRI. In this paper, we present a fundamentally novel technique: the Fibrosis Signature Index (FSI)—the first and only threshold-free, self-calibrated technique for LGE fibrosis/scar quantification. Our approach is based on the probabilistic encoding of ~9 Billion LGE co-disparities per scan, allowing us to quantify fibrosis extent, density, and unique heterogeneity patterns beyond any existing method, including entropy-based approaches. Unlike traditional methods, our technique does not require explicit segmentation of the LA wall (endo + epi) or the scar. Only rough outer LA wall segmentation is needed, thanks to our use of implicit encoding and self-calibration. Validated in 140+ LGE MRI scans (pre- and post-ablation), and across serial post-ablation follow-ups, our FSI technique has demonstrated up to 9 times more reproducibility and robustness (noise, spatial resolution, segmentation errors) than traditional methods. To further strengthen our validation, we developed a novel scan-specific numerical LGE phantom that enables precise control over fibrosis density and heterogeneity. Congratulations to my PhD student Mehri Mehrnia on her first paper, and thanks to the team. #whycmr #3Dlge #atrialfibrillation #ablation IEEE TBME #

🚀 Excited to share that our latest paper in collaboration with the Biomedical Engineering bij Cardiology of Erasmus MC has been published on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)! 📝 Delving into the link between #WSS signatures and atherosclerotic plaque progression in human coronary arteries, this research represents a significant step forward, contributing to pointing out the translational potential of #CFD as a technology able to provide insights into vascular biology and to support decision-making in the treatment of CAD in daily clinical practice.🌟 🛩 It's been an incredible journey working alongside Politecnico di Torino’s (Umberto Morbiducci, Diego Gallo, Elena Torta, Claudio Chiastra) and Erasmus MC’s  (Jolanda Wentzel, Eline Hartman, Joost Daemen) teams. We leveraged our complementary expertise to push the boundaries of knowledge in the hemodynamic-related stimuli of coronary atherosclerosis onset and progression. 📖 Dive into the details of our research here: https://lnkd.in/eRh9B3wK Let's keep pushing the boundaries of knowledge together! 💡 #Research #Publication #Science #Innovation #BiomedicalEngineering

Excited to share that our conference paper titled "Machine Learning-Enhanced Acoustic Reflectometry for Early Detection of Middle Ear Infections" has been published since October 2023! 📚✨ DOI: 10.1109/BMEiCON60347.2023.10322073 This paper represents the collaborative efforts of our research team and showcases our dedication to advancing biomedical engineering. We presented our findings at the 2023 15th Biomedical Engineering International Conference (BMEiCON), contributing to the global discourse on innovative approaches to early detection in middle ear infections through Machine learning model. 🌐🔬 #BiomedicalEngineering #Research #ConferencePaper #MachineLearning #Innovation

Four months at the University of Ioannina and the Unit of Medical Technology and Intelligent Information Systems have provided me with a great opportunity for growth and broadening by horizons, thanks to the Maria Skłodowska Curie DECODE - ITN project. As I wrap up this chapter I am one step closer to finalizing my project on multiscale modeling and surrogate modeling of atherosclerotic plaque progression and providing another contribution to the world of biomedical engineering. #MSCA #DECODEITN #ResearchJourney #biomedicalengineering

𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐭𝐡𝐞 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐨𝐟 𝐭𝐡𝐞 𝐒𝐗𝐓-100 𝐒𝐨𝐟𝐭 𝐗-𝐫𝐚𝐲 𝐌𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐞 𝐚𝐭 𝐄𝐌𝐂 2024: Join SiriusXT and collaborators for illuminating insights in whole-cell imaging! 🔬 Meet with SiriusXT and our collaborators at EMC 2024, Europe’s largest event dedicated to microscopy and imaging, 25th-30th August in Copenhagen, Denmark, to discuss the use cryo soft x-ray microscopy in correlative workflows 🔬 🗣Jakub Javurek, TESCAN, will give a talk elaborating on the topic of “A cryo workflow combining light, electron and soft x-ray microscopy provides targeting of unlabeled features”. 👉Dr. Chris Parmenter, University of Nottingham, will present a poster discussing “Cryo-FIB as a preparation tool for soft x-ray tomography: Analysis beyond EM”. 👉Prof. Roland Fleck, Kings College London, will present a poster, introducing his work on “sample preparation for correlative light, lab-based soft x-ray tomography, and cryo FIB-SEM correlative imaging of biological cells”. 🗣SiriusXT will give a talk on the subject of “3D localisation of nanoparticles in whole cells using correlative cryo soft x-ray tomography and fluorescent microscopy”. 👉SiriusXT will also present a poster on “Correlative cryo soft x-ray tomography and fluorescent microscopy of biological samples in the laboratory”. The image above shows how the position of nanoparticles, used to deliver therapeutics and vaccines to targeted end points in cells, can be tracked using soft X-ray microscopy. (Samples provided by the College of Science, University College Dublin). We look forward to seeing you there!🙂 🌠𝐂𝐡𝐞𝐜𝐤 𝐨𝐮𝐭 𝐨𝐮𝐫 𝐢𝐦𝐚𝐠𝐞 𝐠𝐚𝐥𝐥𝐞𝐫𝐲 𝐭𝐨 𝐥𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐭𝐡𝐞 𝐮𝐧𝐢𝐪𝐮𝐞 𝐛𝐞𝐧𝐞𝐟𝐢𝐭𝐬 𝐚𝐧𝐝 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐬𝐨𝐟𝐭 𝐱-𝐫𝐚𝐲 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲 https://bit.ly/4cJtQS1 🌠   Register today for EMC emc2024.eu #EMC #Science #Copenhagen #Denmark #Research #Conference #Networking #Europe #SiriusXT #SXT #Imaging #Microscopy #Register #UCD #Microscope #Workflow #Therapeutics #Cells #Nanoparticles #Vaccines #EU #Imaging #Innovation

🏆 Congratulations to Arnau Brosa, the Best Undergraduate Thesis winner from the UPC - ETSETB TelecomBCN. 📈 In his Thesis, untitled "Coarse-grained Localization of Inbody Energy-Harvesting Nanonodes," he presents a workflow for standardized performance evaluation of nanoscale devices. These devices could help identify disease biomarkers, viruses, and bacteria, revolutionizing early detection and targeted intervention of #health conditions. ➡ This thesis resulted in the publication "Insights from the Design Space Exploration of Flow-Guided Nanoscale Localization," presented during the ACM International Conference on Nanoscale Computing and Communication (NanoCom) 2024, with co-authors Filip Lemic (who co-directed the thesis), Gerard Calvo Bartra, Jorge Torres Gomez, Jakob Struye, Falko Dressler, Sergi Abadal, and Xavier Costa Pérez. ↘ Find out more: https://lnkd.in/d9dFvGEH #i2CATHealth #i2CATalent

Valerio Lupi, a postdoctoral researcher in Mathematics at the GSSI, was awarded a Marie Skłodowska-Curie fellowship for his research project STETHOS (Stability and transition in extracorporeal blood flow devices: understanding flow-induced hemolysis and thrombogenesis). STETHOS, funded with nearly 180.000 euros for two years, aims to apply computational fluid dynamics to solve medical issues in blood treatment. Specifically, the blood flow in extracorporeal medical devices is exposed to non-physiological conditions, which may lead to red blood cell damage and clot formation. Several drug therapies are provided to patients to prevent these phenomena, but they all come with side effects. “Understanding the causes of flow-induced hemolysis and thrombogenesis would reduce the need for medical therapies, thus enhancing the well-being of the patients”, Lupi explains. Read the news: https://shorturl.at/Bzjxv #GSSI #research #MarieCurie #Maths

🔬 Scientific achievement for the team involved in the ivBM-4PAP research project! 🧪 In Martinez‑Vidal et al, 2024, published in Scientific Reports, by using a Brillouin microscopy approach, the research team explored mechanical alterations in the murine bladder wall, highlighting how tissue fibrosis affects the organ's elasticity. The Brillouin technique allows for the non-invasive, label-free mapping of tissue mechanics, opening up new possibilities for clinical diagnostics. We are proud to have contributed to the recent publication as part of the European Innovation Council and SMEs Executive Agency (EISMEA) Executive Agency research and innovation program in collaboration with Università di Trento Universidad de Zaragoza Université d'Angers and Istituto Italiano di Tecnologia. 🔗 Discover the full article and more insights here: https://lnkd.in/dT7EEtsw   #BrillouinMicroscopy #Horizon2020 #ScientificResearch #Innovation #Microscopy #ivBM4PAP

At the new Max-Planck-Zentrum für Physik und Medizin (MPZPM) in Erlangen, five Core Groups will conduct research to meet the most urgent medical challenges facing our society. Introducing the group ›Neuronal Mechanics‹ led by Prof Kristian Franze: << We are taking an interdisciplinary approach to investigate how mechanical tissue properties, cellular forces and the cells’ response to tissue mechanics contribute to the development and disease of the nervous system. Understanding how cells integrate mechanical and chemical signals in their environment will shed new light on long-standing questions in neuroscience and may eventually lead to novel biomedical approaches to treat or circumvent pathologies involving mechanical signaling. >> Learn more 👉 https://lnkd.in/dKEBd3Tc Atomic force #microscopy (AFM) | Traction force microscopy | Hybridisation chain reactionfluorescence in situ #hybridization (HCR-FISH) | CRISPR/Cas | Custom-built soft cell culture substrates | Xenopus laevis | #Neurons | #Axon pathfinding | Mechanotransduction The #MPZPM is an interdisciplinary joint research center of the Max Planck Institute for the Science of Light (MPL), the FAU Erlangen-Nürnberg (FAU) and the Universitätsklinikum Erlangen (UKER).

At the new Max-Planck-Zentrum für Physik und Medizin (MPZPM) in Erlangen, five Core Groups will conduct research to meet the most urgent medical challenges facing our society. Introducing the group ›Tissue biomechanics‹ led by Prof Benoît Ladoux: << Our team studies the physical principles governing the self-organization of cellular and tissue systems as well as their adaptation to mechanical constraints of the environment. The research aims at understanding how cell adhesion-associated mechanotransduction and mechanosensing regulates cell behavior and tissue mechanics. We develop new technologies to mimic in vivo mechanisms, map, and disrupt the physical properties which determine the growth, movement, invasion, and remodeling of cells and tissues. By combining this physical information with molecular perturbations and theoretical models, we explore the principles governing the interaction between chemical and physical signals in living tissues. >> Learn more 👉 https://lnkd.in/d4RQF2fC #Microscopy | Cell mechanics | Active matter | #Microfabrication The #MPZPM is an interdisciplinary joint research center of the Max Planck Institute for the Science of Light (MPL), the FAU Erlangen-Nürnberg (FAU) and the Universitätsklinikum Erlangen (UKER).