Taconic Biosciences’ Post

Interesting "molecular pathways of aging" work from an impressive team at Harvard Medical School: Your biological age should NOT be ONE number. Introducing Ageome: our new framework that measures aging across thousands of molecular pathways simultaneously 🧬. Ageome challenges the single-number paradigm of biological age, offering a high-dimensional view of aging across biological functions. Check out our new preprint here https://lnkd.in/gf6kPD8m

Chromatin remodeling dynamics revealed at the single-molecule level! In a recent #eLife publication, scientists from Johns Hopkins University and Howard Hughes Medical Institute made a groundbreaking discovery of chromatin remodelers, which employ various mechanisms when interacting with DNA and nucleosomes. With cutting-edge dynamic single-molecule analysis, the researchers provided the first real-time, detailed observation of these dynamic processes at the single-molecule level! https://bit.ly/4bwKseJ

You're invited to our webinar series on everything cell type taxonomies! On-Demand - Cell Types 101 January 31 - What is a taxonomy? February 28 - Techniques behind the Cell Type Knowledge Explorer March 27 - Cross-species cell types April 24 - What is your cell type: MapMyCells May 22 - Introduction to Allen Brain Cell Atlas RSVP at: https://lnkd.in/gGT-hyen #AllenLearn

Go check out some of my graduate work published at JNeurosci! It is known that our amygdala shows robust theta oscillations during emotional processing, and here using a mouse model we show a circuit mechanism by which this can occur.

Want to learn more about proteomics of the heart? Check out our latest review article, huge effort led by Oleg Karpov!

Listen to BAF Research Grant Recipient and Board Member, Vincent M. Tutino, Ph.D. He will share all things brain aneurysm related; exploring topics such as how and why they form, what causes them to grow and rupture, the best treatment options available, and the latest advancements in detecting aneurysms. https://lnkd.in/e68m_DFd

STEALTH LONGEVITY My latest article is out, and it focuses on translational fidelity. Posited initially as the leading cause of aging theories associating translational errors and aging were considered dead in the 80s. However, a series of findings in the last few years has resurrected it as a potential intervention to extend human healthy lifespan As always, I add a list of exciting researchers and papers on the topic. P.S. One of VitaDAO's spinout, @ArtanBIO, focuses on a mechanism to improve translational fidelity https://lnkd.in/dPJK9kTa

Multiplex live imaging is a powerful tool to study dynamic cellular processes – but it can also be complex and challenging. Read this article for an overview of the key aspects of setting up a successful multicolor live-cell experiment! 👉 https://fcld.ly/cepjwdg Video: 12h confocal time-lapse video of dividing RPE cells stably expressing eGFP-tubulin (cyan) and iRFP-Histone H2B (magenta). Courtesy of C. Gliech, Holland Labs, John Hopkins School of Medicine, Baltimore, US. The Holland lab is interested in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. #Microhubimaging #fluorescencemicroscopy

A groundbreaking discovery is inside us! Our bodies, a universe teeming with life, have just become even more fascinating. Stanford scientists have uncovered what they're calling "Obelisks" – an entirely new class of biological entities residing within us. Basically, tiny bits of RNA—even smaller than viruses—colonize the bacteria inside human guts and mouths. This revelation adds another layer to our complex internal ecosystem, comprised of trillions of microbes, including bacteria, viruses, fungi, and more. What does this mean for medical science? Understanding these obelisks could revolutionize our approach to health and disease. Their functions, interactions with other microbes, and impact on our wellbeing are now subjects of intense study. This discovery underscores the incredible complexity of the human body and opens new avenues for research and potential treatments. I wholeheartedly agree with the significance of this finding. The more we learn about the microscopic worlds inside us, the better equipped we are to tackle health challenges. It's a reminder of how much there is still to discover and how each finding can potentially lead to breakthroughs in medicine. The journey into our own inner universe just got more exciting. Let's stay curious and open to the endless possibilities that lie within us. Check this out: https://lnkd.in/g4zTVYPV

📣 Day 4 at #SfN24! We're heading to Sadie May Wasberg's presentation from Isabel Muzzio's Lab at University of Iowa! Their research explores how the auditory cortex (AC) helps animals detect and respond to threatening sounds by strengthening responses to learned fear cues. Using calcium imaging, they’ve uncovered the vital role of AC neurons in retrieving fear memories, shedding light on the circuits involved in anxiety disorders. Check out the full abstract here ➡️ https://hubs.ly/Q02StPV00