Talus Bio’s Post

I had the privilege of representing Beacon at the 2nd Molecular Glue Summit last week and meeting the individuals leading the molecular glue and degrading space. My key takeaways: 🤖 Learning insights about how AI can supplement the forward prediction of molecular glue rational discovery. ❓ Answering questions about ensuring high bioavailability of orally delivered molecular glues. 🤔 How we can comprehensively expand the glueable E3 Ligase landscape beyond CRBN, VHL and DCAF15? 🚀 How to fast-track IND-filing and accelerate the progression of novel molecular glue candidates to the clinic. I was reminded from my conversations over the 3 days that in such a rapidly growing field (58% gross growth last year alone) keeping pace with the preclinical and clinical landscape in depth is unmanageable. As Beacon expands, we're tracking over 200 molecular glues and more than 1,500 degraders at the most granular level of detail to tackle this challenge. Here's 5 molecular glues we're tracking that are looking beyond CRBN, VHL and DCAF15: https://lnkd.in/eB6niSsW P.s If you're like to learn more about your own degrader's competitive landscape drop a message or a comment and I'll send over some info.

"Precision medicine is a therapy or treatment that is tailored just for you. All of us are individuals and individuals at a genetic level, and therefore, your treatment to be really effective has to be specific enough to address your specific genetics." Rosy Lee, our VP and General Manager of Life Sciences Mass Spectrometry, joined Clinical Lab Chat to discuss how recent advances in genomics and proteomics are unlocking new possibilities for human health. Listen to the full episode for more insights from Rosy and how Thermo Fisher Scientific works with our partners to enable precision medicine ⬇️

"Precision medicine is a therapy or treatment that is tailored just for you. All of us are individuals and individuals at a genetic level, and therefore, your treatment to be really effective has to be specific enough to address your specific genetics." Rosy Lee, our VP and General Manager of Life Sciences Mass Spectrometry, joined Clinical Lab Chat to discuss how recent advances in genomics and proteomics are unlocking new possibilities for human health. Listen to the full episode for more insights from Rosy and how Thermo Fisher Scientific works with our partners to enable precision medicine ⬇️

Learn how to reliably culture, differentiate, and expand T-cells using chemically defined media and recombinant human proteins from FUJIFILM Irvine Scientific. Attend our presentation on February 28th, at 2:30 PM GMT with Field Application Scientist, Ivo Urh, and stop by booth 13 to discover the benefits of chemically defined conditions in your cell culture process. https://brnw.ch/21wHdD8

Our work "Enhancing Region-Based Geometric Embedding for Gene-Disease Associations" has been accepted and presented in ACM CODS-COMAD 2024, which happened in Bengaluru in Jan 2024. In this work, we tried to use the geometrical knowledge graph embedding (KGE) method to represent biomedical entities as n-dimensional convex-shaped objects in vector space inspired by Kulmanov et al. work(link in paper reference) to perform gene-disease association prediction. We achieved encouraging results. The model is based on the principles of EL++ Description Logic and we used HPO (Human Phenotype Ontology) as our KG/dataset. Link of our paper: https://lnkd.in/gXZfyE9G

We are excited to share an exceptional webinar featuring Dr. Gómez-Romero from the National Phenome Centre, a leading voice in Mass Spectrometry. Dr. Gómez-Romero explores metabolic phenotyping studies, revealing unique metabolic signatures associated with specific conditions. Join us as we discover the fascinating world of metabolic profiling, analysing small molecules in biological samples to understand living organisms' metabolic processes. Ideal for scientists in academia, industry, research labs, and biomedical fields interested in metabolomic and lipidomic research. Learn key aspects: 💡 Study design's significance in large-scale metabolic phenotyping 💡 Boosting result confidence through platform stability 💡 Maximizing LC-MS data for metabolic phenotyping Click the link below and dive into the world of cutting-edge research and innovation. https://lnkd.in/d8bBdXcF Microsep (Pty) Ltd Waters Corporation #WatersWebinars #MassSpectrometry #MetabolicPhenotyping #Microsep

Due to parameters such as differences in length, chemical modifications, conjugation events etc, a comprehensive portfolio of oligonucleotide characterization techniques are available at BioPharmaSpec.!

🔬 Did You Know? Sequencing the first human genome took 13 years and cost $3 billion. But today, with modern sequencers—even pre-owned ones—you can get it done in just hours for under $1,000! 🚀🧬 Discover the power of pre-owned lab equipment with BaneBio!

The value of instrument reliability for large‑scale metabolic profiling webinar. Click the link below and dive into the world of cutting-edge research and innovation. https://lnkd.in/d8bBdXcF