Tanaz Saatchi’s Post

LHI Lecture April 17, noon: “Endoplasmic Reticulum-Mitochondria Contact Sites and Cardiac Fibrosis” Jin O-Uchi, M.D., Ph.D. Assistant Professor of Medicine Cardiovascular Division Lillehei Heart Institute University of Minnesota Medical School More about Dr. O-Uchi from his lab website: https://buff.ly/3TI7U1N Location: 1-101 Microbiology Research Facility (MRF) 689 23rd Ave SE, Minneapolis, MN Map: https://buff.ly/3VJm19Z Webcast @ buff.ly/4cIssQI Learning Objectives 1. Recognizing sarcoplasmic/endoplasmic reticulum(SR/ER)-mitochondria (Mito) contact sites as one of the key structures for the calcium and ROS regulation in the heart. 2. Identify molecular mechanisms regulating ER-Mito contact site in cardiac fibrosis. 3. Design mechanism based treatment strategies to ameliorate cardiac fibrosis.

A Bruker IVDr* spectrometer helped gastroenterology clinical researchers to gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS). Read the article: https://lnkd.in/dA_mbA4q Learn more about Bruker Avance IVDr and NMR* clinical research solutions and applications: https://lnkd.in/d82BFgut Taylor & Francis Group *Bruker NMR Instruments are for Research Use Only. Not for Use in Clinical Diagnostic Procedures. #Metabolomics #Gastroenterology #IBS #irritablebowelsyndrome #NMR

📢 Interesting new paper by HIH research group leader Sven Poli and first author Tobias Geisler, the principal investigators of the #ATTICUS randomized trial, on “#Apixaban versus #Aspirin for #Embolic #Stroke of Undetermined Source” Rivaroxaban and dabigatran were not superior to aspirin in trials of patients with embolic stroke of undetermined source (ESUS). The ATTICUS trial evaluated whether apixaban is superior to aspirin in patients with ESUS and additional risk factors for cardioembolism.    Geisler & Poli conducted a multicenter, randomized, open-label, blinded-outcome trial of apixaban (5mg twice daily) compared with aspirin (100mg once daily) initiated within 28 days after ESUS in patients with at least one predictive factor for atrial fibrillation or a patent foramen ovale. Cardiac monitoring was mandatory, and aspirin treatment was switched to apixaban in case of atrial fibrillation detection. The primary outcome was any new ischemic lesion on brain magnetic resonance imaging (MRI) during 12-month follow-up. Secondary outcomes included major and clinically relevant nonmajor bleeding.  👉 Check out the full article in NEJM Evidence NEJM Group: https://lnkd.in/ehHRvytH

We have recently published a review article about bioimpedance spectroscopy (BIS) in phlebolymphedema; we highlighted some general principles about the use of BIS in the management of limb phlebolymphedema, reporting also data from literature and from our personal experience in the last two decades. Overall, BIS represents an extremely valuable diagnostic option to quantify fluid retention and tissue changes in phlebolymphology, both in the field of scientific research and in the daily practice. At this link you may find our article: https://lnkd.in/dpvGYxpe

A great step towards realistic cell culture models

#medicine DAPT after PCI still seems to have good clinical economics. PCI後のDAPTはやはり臨床経済が良いようです。 https://lnkd.in/gzEqyPFK Consideration of the Medical Economics of Cardiac Genetics, Focusing on the Cost-Effectiveness of P2Y12 Inhibitor Selection Based on the CYP2C19 Loss-of-Function Allele: A Semi-Systematic Review

Enhance Your Cystic Fibrosis Research with Our Synthetic Cystic Fibrosis Models (SCFM) Are you ready to take your CF research to the next level? At SynthBiome, we are proud to offer high-quality Synthetic CF Media designed to meet the rigorous demands of modern CF research. Why choose our SCFM Model? ·      Realistic Conditions – SCFM is meticulously formulated to replicate CF sputum, providing a reliable model for studying pathogens such as P. aeruginosa and S. aureus. ·      Consistent and Reproducible – standardized composition ensures consistent results, making your research reliable and comparable across different studies and laboratories. ·      Enhanced research outcomes – With our SCFM, you can identify therapeutic targets and research new treatment avenues in an in vitro environment that closely mimics the actual conditions of CF patients. ·      Save Time and Resources – Spend less time adjusting variables and more time on experiments. What sets us apart? ·      Most Accurate Model for Human CF Lung ·      Quality Assurance ·      Customer Support ·      Sole Producer – we are currently the only commercial producer of Synthetic CF Models. Ready to improve your research? Contact us today to learn more about SCFM and how it can benefit your research. Let’s drive innovation together and make a significant impact on CF research. Visit Our Website: https://lnkd.in/eHv-CiKf Email Us: contact@synthbiome.com #CysticFibrosis #SCFM #BiomedicalResearch #Innovation #Healthcare #Microbiology #CFResearch #SynthBiome

🔍 Exploring Advanced Tools in Cardiotoxicity Research! Kudos to our colleague Julio Martin for his insightful post on Discovering the Power of SPAchip for Analyzing Cardiotoxicity and Ferroptosis! 🚀 In the fast-paced world of cardiovascular research, having precise and reliable tools is crucial. #SPAchip technology is transforming how we approach cardiotoxicity studies, especially in the context of anthracycline-induced ROS production. 🌟 Why SPAchip is a Game-Changer: -Real-time Monitoring: Allows us to observe ROS dynamics as they unfold, leading to quicker, more accurate insights. -High Sensitivity: Detects even the smallest changes in ROS levels, ensuring no detail is overlooked. V-ersatility: Applicable across various cell types and experimental conditions, making it an essential tool in any lab. -Selectivity: Specifically detects hydroxyl radicals, which are key players in oxidative stress and programmed cell death, including ferroptosis. These capabilities not only enhance our understanding of drug-induced ROS production but also accelerate the development of safer therapeutic strategies. With tools like #SPAchip, we can draw more precise conclusions in less time, pushing the boundaries of what’s possible in cardiovascular research. Let’s continue to advance the field together! For more insights, check out the full article on ARRAYS FOR CELL NANODEVICES, SL - A4CELL’s Blog 👉 https://lnkd.in/dbuV4jZf #Cardiotoxicity #Ferroptosis #SPAchip #ROSDetection #CardiovascularResearch #Innovation

Pulsed Field Ablation is a new cardiac ablation method based on electroporation that is being rapidly introduced into the clinical practice for treatment of atrial fibrillation. Many questions still remain about how electroporation affects cardiac tissue on the cellular level and how electroporation may affect expression and function of ion pump machinery in cardiac cells that is crucial for continuous contractility of heart muscle. We explored some of the open questions in our paper published recently in Applied Sciences. If you're interested in said topic I'd love for you to give it a look :)

Forging the path to revolutionary drug development and medical breakthroughs! 🚀 Researchers at the National Institute of Standards and Technology (NIST) have developed a #HeartOnAChip system that attacks the limitations of traditional cardiovascular disease research head-on. This innovative microchannel is not just a part of a larger Organ-On-A-Chip network system but a beacon of hope in cardiovascular disease research. Designed to mimic the human heart, it allows experts to manipulate and study the behaviour of cells under controlled conditions, leading to more accurate results. Let's applaud Derrick B. and Darwin Reyes for their remarkable achievement! 👏 Read more about this impressive research here:  https://lnkd.in/dEZiX52F. #MedicalResearch #OrganOnAChip #LabOnAChip #MicroFluidics #Nanostructure #NanoBioTechnology #NanoimprintLithography #UVNIL