Targeted Bioscience, Inc’s Post

We're here at the 12th Annual Tumor Models Boston Summit! Meet our team to network and discuss the latest innovations in tumor models. Don't miss the opportunity to discuss how these innovative solutions can move your research forward. Discover the infinite power of partnership to drive scientific discovery and advance your research with our cutting-edge offerings. Our portfolio includes: ✅Pre-Treated Models: Access to models pre-treated to suit your specific research needs. ✅OrganoidXplore™: Explore our advanced organoid models for more precise study outcomes. ✅3D Advanced Models: Discover the next generation of 3D models that enhance the translatability of your studies. #Biotech #Bioscience #Oncology

🔬 𝗗𝘆𝗻𝗮𝗺𝗶𝗰 𝗧 𝗰𝗲𝗹𝗹 𝗯𝗶𝗻𝗱𝗶𝗻𝗴 𝗰𝗮𝗽𝘁𝘂𝗿𝗲𝗱 𝗟𝗜𝗩𝗘 🔬 Automated segmentation of cells shows exactly where and when T cells interact with a target cancer cell (blue). Cells are colored digitally by Nanolive's LIVE T Cell Assay (no fluorescence needed!). Detected interaction sites are colored yellow, and unbound T cell surfaces are colored red. This 10 minute capture by the lab of Dr. Eliana Stanganello at TRON-Mainz, was used to quantify T cell and target cell interactions over time. Learn more about the Live T Cell Assay here: https://bit.ly/3Ru7L1H #nanolive #biotechnology #celldeath #technology #sciencecommunication #medtech #health

Highly Sensitive Quantitative Imaging for Monitoring Single Cancer Cell Growth Kinetics and Drug Response Traditional methods of studying cell growth and drug response involve laborious sample preparation and invasive techniques that alter cell function. By eliminating the need for exogenous labels, SLIM (Spatial Light Interference Microscopy) avoids potential perturbations or interference with cellular processes. Researchers used SLIM to measure the growth of individual and bulk cancer cells treated with estradiol and antiestrogen over time. They could directly measure cell area, volume, and dry mass, providing insights into cell growth kinetics. Quantifying these results at individual and bulk cell levels over long time scales without invasive techniques is currently only available through SLIM. Read more about the science in PLOS: https://lnkd.in/gHhVpq7X Further information on SLIM can be found at phioptics.com. #CancerCellGrowth #QuantitativeImaging #DrugResponse #SLIM #CellGrowthKinetics #SpatialLightInterferenceMicroscopy #PLOS #CellResearch

Want to know how #spatialtranscriptomics can revolutionize #cancer research? Discover 10x Genomics innovative approach helps researchers pinpoint potential #drug targets and unravel mechanisms of cancer resistance by visualizing #biomarkers, cell–cell interactions, and #tumor transcriptomes within the native #tissue architecture. Read more here: https://zurl.co/dsUI

🔬 Excited to share our latest preprint Science Cast on LinkedIn! "Drugs targeting microRNAs that regulate DNA damage sensing and repair mechanisms: A computational drug discovery approach" outlines our innovative approach to identifying potential therapies that modulate DNA damage response pathways through microRNA targeting. This research holds promise for advancing personalized medicine and enhancing cancer treatment strategies. Check out the preprint here to learn more about our computational methodologies and the implications for future drug development. https://lnkd.in/g_rJe7Qu

The agenda for Discovery on Target is now available! This year's event highlights the latest advancements in popular topics like #kinases, #immunomodulation & #degraders, plus new coverage including covalent chemistries, induced proximity, synthetic biology, cancer antibodies, and generative AI & translational models. View the brochure or visit our website for more information and to book your spot: https://lnkd.in/gS4S5ihv #BostonDOT24 #DrugDiscovery #Biotech #syntheticbiology #covalentchemistries #inducedproximity #oncology #generativeAI

A recent editorial by S. Danti et al. highlights how 3D biomaterial-assisted in vitro models are transforming cancer research by offering a more accurate representation of tumor biology compared to traditional 2D cultures. These advanced models, supported by platforms like #MIVO, significantly improve the mimicry of in vivo cell interactions, tissue architecture, and therapeutic responses. The MIVO platform provides a highly biomimetic system that precisely models the #TumorMicroenvironment, leading to enhanced predictivity in drug sensitivity and treatment outcomes. It allows researchers to explore complex biological processes—such as cellular responses to therapies—far beyond the capabilities of conventional 2D models.

Read "Precise Quantitation of Blood Lipoprotein Subclasses Helps Risk Screening for Nasopharyngeal Cancer" by 谱天生物ProteinT where researchers from 南方医科大学 analyzed plasma samples from patients using Avance IVDr #NMR platform* spectroscopy and developed a risk stratification model based on MRI risk scores for personalized assessment of high-risk groups (website in Chinese): https://lnkd.in/eFBS7CD7 Join us for an insightful webinar and discover how our translational achievements in NMR technology are poised to revolutionize clinical research settings: https://lnkd.in/eDJKKthH #Oncology *Research use only. Bruker NMR instruments are not intended for use in clinical diagnostic procedures.

BioChain’s Total RNAs are isolated from a wide variety of documented human normal, diseased, and tumor tissues, and mouse, rat, monkey, and plant tissues. BioChain is a service and product provider dedicated to improving the understanding of cancer development and streamlining your therapeutic development. https://bit.ly/4b3sstM #spatialbiology #biotech #RNA #tissues #cancerresearch #biochain #spatialtranscriptomics

Brian Weitzner put together an excellent overview of our protein design capabilities and a preview of some of the work we've been grinding on for the last couple years. If you're at #PWMC24 make sure to check out his presentation