Technology Networks’ Post

A must-watch for those interested in #DrugDiscovery! Dr. Peter Hsueh dives into screening strategies in this episode of Teach Me in 10. Check it out!

We are excited to share how Crystal Pharmatech utilizes PBPK modeling for the fastest and most efficient formulation development. Register to attend!   Subject Matter Expert, Ridwan Islam, M. Pharm., Ph.D., will present: “Utility of PBPK Modeling as Step 1 in a 3-Step First Time Right Crystal Pharmatech Formulation”   Abstract: PBPK modelling is a valuable tool to address a much wider range of pharmaceutical applications besides drug-drug interactions. We present here PBPK modeling applications routinely used at our CDMO for in-vitro to in-vivo translation and pharmacokinetic modelling in preclinical species in addition to first-in-human pharmacokinetic predictions. Linking of in-silico quantitative structure–property relationship models with (PBPK) modelling is Step 1 of a tailored Formulation for Phase I. Combined with parameter sensitivity we can clearly identify the key compound API Form and Formulation properties. This leads to the fastest, most efficient formulation development with visibility into future clinical trials.

We are dedicated to advancing ulviprubart, our investigational product candidate, a potential first in class treatment for people living with #InclusionBodyMyositis, a devastating, chronic disease that impacts daily activities. We believe ulviprubart, an anti-KLRG1 antibody, currently in clinical trials, represents a novel approach to selective depletion of the highly cytotoxic T cells that attack the muscles of those living with #IBM. Learn more about our science, pipeline and clinical trials: https://lnkd.in/eqETNKPs   #MyositisAwarenessMonth #Biotech #Autoimmune #IBM

The SeromYx team is excited to announce the release of our new white paper titled, "View from the Fc: Five Rules for #mAb Development Risk Reduction." 💡 What you'll learn: 💠 The importance of comprehensive Fc function profiling 💠 The need for whole molecule screening 💠 The impact of the immune complex and Fc engineering on effector function At SeromYx, we specialize in profiling and measuring Fc-driven effector functions, with expertise in both vaccines and #monoclonalantibodies. Our new paper shares valuable insights and lessons learned that could help mAb developers navigate these challenges more effectively. #antibodytherapeutics 🔗 Link to download: https://lnkd.in/dChggSvp

The future of cell culture and human-relevant screening is here. You will not want to miss this #SLAS2024 talk with Oksana Sirenko of Molecular Devices on their revolutionary new CellXpress.ai Automated Cell culture system. See more: #DanaherLifeSciences #organoids #CellXpress.ai #3DBiology #AIML

We are here at the Emergence of Irreversible Modulation in Drug Discovery conference in Cambridge! 🧬💊 Stop by our booth today and tomorrow (October 16-17) to chat with Timothy Orwell about how we can support your drug discovery journey. 📖 Learn More: https://lnkd.in/eYV2eKFp #DrugDiscovery #IrreversibleModulation #Spectroscopy

📽 Get a look at the four applications available within the #Chemistry42 platform. They include: -#GenerativeChemistry -#Alchemistry -ADMET Profiling -Golden Cubes Chemistry42 is a comprehensive #smallmolecules drug discovery platform. It streamlines hit identification, hit-to-lead, and lead optimization programs. See how it can help expand your research needs today: https://lnkd.in/ePQcTM2D #DrugDiscovery #GenerativeAI

From the lab to the bench, scaling up regulatory #Tcelltherapy #RegulatoryTcells (#Tregs) are crucial for maintaining #immunebalance and preventing overactive #immuneresponses. While their therapeutic use is a rapidly expanding field of research, producing Tregs presents significant challenges, including contamination risks and human error. Next week, Thermo Fisher Scientific’s Hany Meås and the University of British Columbia’s Megan K. Levings will discuss the growing potential of Treg #celltherapy for treating #autoimmuneconditions, and the considerations for producing these therapeutics in a closed, automated environment. Register for this #webinar below:

Free webinar: Discover next-generation multiplexing with the new Triceratops SPR # 64 and learn about the additional insights surface plasmon resonance brings to your drug development projects. Register here: https://lnkd.in/gdEBJDjs #webinar #spr #surfaceplasmonresonance #drugdiscovery