APC ’s Post

The unique molecular fingerprint and non-destructive analysis provided by #Raman spectroscopy make it an ideal technique for drug identification and characterization. Read more about Raman, drug ID, and how the right optical filters make it all possible in our newest article from Hongbai Lao published by Photonics Online. https://lnkd.in/ekNA3AWV IDEX Optical Technologies

Excited to get into the quantum world and explore the potential of quantum-based models in the Pharma industry! Two great and recent examples in the links below: A Schrödinger Equation for Evolutionary Dynamics - https://lnkd.in/dvEPJUkr Application of DFT Calculations in Designing Polymer-Based Drug Delivery Systems: An Overview - https://lnkd.in/d3iiCZCt

The beauty of advanced computational chemistry in accelerating drug discovery when confronting challenging targets lies in its ability to quickly model protein-ligand interactions and reduce lab-intensive trial-and-error. GPX4 is known for its shallow and flat ligand binding pocket, which poses significant challenges for non-covalent small molecule inhibitor drug design. XtalPi Free Energy Perturbation (XFEP) utilizes the proprietary force field to calculate and capture the protein-ligand interactions of potential pharmacophores for non-covalent small molecule design. Validated hit compounds were rapidly identified through our automated library synthesis platform. Click the link provided below to see the full story of "How XtalPi identified novel, non-covalent, potent hits against GPX4 in just 28 days" https://hubs.li/Q02S19qj0

Maximize the potential of your antibody projects with our comprehensive antibody characterization capabilities. Explore below the 5 reasons why partnering with us makes a difference! Interested in learning more about our Biophysical and Functional Characterization? Check out: https://lnkd.in/dku2KQby #antibody #biotech #antibodycharacterization

🔬 Research Alert! published in #DrugDevIndPharm. 2023, VOL. 49, NO. 3, 249–259 🤩 "In vitro and in silico computational methods for assessing vaginal permeability" 🌟 This study focuses on the development of quantitative structure-permeability relationship (QSPR) models to predict the vaginal permeability of drug candidates. The study used in vitro experiments to determine the apparent permeability (Papp) of 108 compounds and collected various descriptors related to the structural and physicochemical properties of each compound. Two QSPR techniques, partial least square (PLS) and support vector machine (SVM), were applied to develop predictive models. The models were validated and assessed for their performance using statistical parameters. 📖 Read the full article here: https://lnkd.in/dNgiYYXc

Conventional methods of modeling or representing chemical structures are no longer adequate for the growing complexity and intricacy of new drug modalities. HELM enables scientists to clearly communicate about drugs. Learn how in the new #RevvitySignals blog!

🔬 Exciting breakthrough in Pharma Industry! Real-time analysis just got a major boost with High-Throughput Virtual Slit (HTVS™) enabled Raman spectroscopy. Our recent study showcases its efficacy in verifying inclusion complex formation in novel drug delivery systems. This tech offers unparalleled insights into physicochemical properties during development and production, ensuring pharmacological integrity. With 10x faster measurements and 3x improved detection limits, Tornado Raman spectrometers revolutionize process monitoring. Empowering Pharma with precise control over drug delivery systems, it promises enhanced efficiency, reduced costs, and optimized outcomes. Discover more about this game-changing solution! Download: https://lnkd.in/eQG76h_u #PharmaInnovation #RamanSpectroscopy #DrugDeliverySystem #ProcessMonitoring

This summer, continue exploring our #ArdenaExpertInsights series featuring weekly Q&As with our specialists on critical drug development topics. Next in the series, delve into an in-depth Q&A with our Nanomedicine experts Wouter Veldmate, MSc., Senior Scientist – Process Development, and Silvie Meeuwissen, Ph.D., Director Process R&D and Manufacturing. They discuss "Using Flow Technology in Nanoparticle Synthesis." Discover how flow technology offers unique advantages over conventional batch technology, enhancing process safety, scalability, and product consistency in the synthesis of nanoparticles. Read the full Q&A below. Stay engaged and participate in the conversation! #Ardena #DrugDevelopment #NanomedicineExperts #FlowTechnology #PharmaceuticalInnovation

🔔 Exosome Purification At VDO BIOTECH, we specialize in exosome purification using advanced chromatographic techniques. We have successfully delivered multiple purification projects to our clients, all receiving high praise for their quality. Our size exclusion chromatography method effectively separates exosomes from other sample components based on molecular size differences. This approach not only maintains the integrity and bioactivity of the samples but also allows for scalability, making it ideal for processing large sample volumes. hashtag#ExosomePurification hashtag#Resins

Enterprise collaboration is quite important in accelerating drug development. check out this one !!!