The BRAIN Foundation’s Post

Advancing Autism and Neurodiversity Research This World Autism Month, we spotlight research into Autism and Neurodiversity. Dr. Megan Williams at the University of Utah made a significant breakthrough with her discovery of a new class of GABA neurons linked to autism. This work, funded by our Seed Grants, highlights the potential for new treatments and deeper understanding of neurodiversity. Discover past Seed Grant recipients and see how these projects funded by BRF drive pivotal research. https://lnkd.in/ehNjtjpi Together, let’s empower progress and positively impact the lives of those affected by neurological disorders. #AutismAwareness #ResearchImpact #Neurodiversity

GNCs neuroscientist Nouchine Hadjikhani has co-authored a new book entitled "Treating Autism with Bumetanide". Drawing on the authors' combined expertise in brain development, ASD treatment, and brain imaging, this book presents a fresh perspective on ASD". #autism #bumetanide #ASD #asdawareness #medicalresearch

🧠Groundbreaking study reveals lower platelet BDNF levels in adults with ASD, linked to specific symptoms🌟Paving the way for deeper understanding of neurobiology in ASD🔍 @Biomed_MDPI @MDPIOpenAccess #AutismResearch #BDNF #NeuroBiology https://lnkd.in/dEJbP2RZ

Worldhealth.net A large-scale international study has uncovered hundreds of genetic variants that influence #brain volume, revealing strong links to #ADHD and Parkinson's disease. #Researchers pinpointed where these genes act in the brain, offering new insights into the biological basis of these conditions and paving the way for more targeted treatments. #worldhealth #neuroscience #parkinsons #brainresearch #antiaging #aging #regenerativemedicine #medicine #clinicalresearch #health https://lnkd.in/gpyBQBTS

👏 We are excited about the recent study identifying maternal autoantibodies reactive against fetal brain antigens, which opens new possibilities for early autism spectrum disorder (ASD) screening and diagnosis. These findings underscore the potential 💫 of antibody reactome profiling in understanding 🧠 neurodevelopmental disorders and developing early diagnostic tools ⚙️ .   📗 Read more about the article here: https://lnkd.in/gcVNPtKF Published by Frontiers in Neuroscience #autoantibody #immunology #research #neuroscience #autism

In #autism and #Alzheimer's, impaired neuronal connectivity and synaptic function cause #cognitive and #behavioral issues. Understanding the mechanisms involved is crucial for developing therapies. This study sheds light on CNTN4's role and its protein interactions, linking autism and Alzheimer's. These findings could clarify the pathogenesis of these #neurodevelopmental and #neurodegenerative diseases and offer new treatment targets.

🔍🧬 Advancing Autism Diagnosis: Yale Study Reveals Critical Insights 🧬🔍 A groundbreaking study by Yale scientists in the field of autism spectrum disorder (ASD) research has identified two neurodevelopmental abnormalities pivotal in the disorder's emergence. Utilizing brain organoids derived from stem cells, the team has uncovered distinct differences in excitatory neuron growth among children with ASD, setting a foundation for early diagnosis and customized therapeutic interventions. This innovative approach not only enhances our understanding of ASD but also highlights the potential for targeted treatments to improve patient outcomes. Embrace this stride towards precision medicine in neurodevelopmental disorders. https://zurl.co/UYlj #AutismResearch #NeuroscienceInnovation #PrecisionMedicine #HealthcareAdvancements #YaleStudy

🌍 April 2nd, 2024, marks International Autism Spectrum Disorder (ASD) Awareness Day. At Neuroservices-Alliance, we stand in solidarity with the ASD community and are committed to supporting research and development efforts in this field.   We propose innovative electrophysiology assays and ASD behavioral models that can be key to advancing ASD drug development. By partnering with us, researchers and pharmaceutical companies can gain valuable insights into the neurobiological underpinnings of ASD, paving the way for the development of more effective therapies and interventions   🔗 Visit our website for more information: https://lnkd.in/gtbuw8qr   Together, let's continue to advance research we can make a difference in the lives of those affected by Autism Spectrum Disorder.    #ASDAwareness #AutismAcceptance #WorldAutismawarenessmonth #Autismawarenessmonth #Autism #Research #AutismAwareness #InclusionMatters

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder Metabolism is strongly linked to child development. Children with ASD exhibit distinct metabolic profiles that vary by age, sex, and symptom severity. These profiles, in part, appear to drive the neurodevelopmental aspects of ASD. This study employed classical and network metabolomic analysis to identify key metabolic differences in 5-year-olds with ASD. These differences involve phospholipid metabolism, fatty acid oxidation/acyl-carnitines, and sphingolipid metabolism. Notably, 80% of the metabolic impact stems from shared pathways identified in both pre-ASD newborns and affected children. The ASD metabolic phenotype is characterized by decreased anti-inflammatory/antioxidant molecules (glutathione, carnosine, folate, CoQ10) and a coordinated increase in stress metabolites (lactate, glycerol, alanine, threonine, cholesterol, ceramides). Importantly, the magnitude of these changes worsens with age. The original article was published in Comm Biol https://lnkd.in/d5EkmrUX. https://lnkd.in/d37JDneX #genetics #genomics #precisionmedicine #genomicmedicine #asd #autism #brain #neurology #neurodegenetation #neuroscience #metabolism #neurodevelopment #development #lipids #inflammation #immunity #immunology #oxidation #ros #biomarkers #therapeutics #biotechnology #innovation #research #science #sciencecommunication

Recently published research by Nathan Schoppa, PhD, a professor of physiology and biophysics in the CU School of Medicine, may point the way to new treatments for autism spectrum disorders. Read more about Schoppa's research here: https://bit.ly/48WAbIg #Autism #Research #Medicine