The Medical Letter’s Post

Check out this Methodology, detailing a hybrid IA–LC–MS/MS method for adrenocorticotropic hormone(1–24) to support the interpretation of low-dose cosyntropin-stimulation tests: https://hubs.ly/Q02V3jPT0

Ion transport peptide (ITP) in Drosophila governs tumour-induced renal dysfunction. Read more here: https://lnkd.in/gvBZ-jRa

1. Absorption: Lignocaine is absorbed quickly into the bloodstream when administered via injection or topical application. 2. Distribution: It is distributed throughout the body, with higher concentrations in tissues with high blood flow. 3. Metabolism: Lignocaine is metabolized by the liver enzyme cytochrome P450. 4. Excretion: The metabolites are excreted in the urine.

Semaglutide improves metabolic dysfunction‐associated steatohepatitis: A 10‐year retrospective study https://lnkd.in/gU_68rA8

PHARMACOKINETICS :: Levodopa is rapidly absorbed by an active transport Decrease in gastric emptying time and low pH decreases absorption The peak effect is reached in half an hour Half life of levodopa is 1-3 hrs About 95% of levodopa is metabolized peripherally and only 1% crosses blood brain barrier Excretion of levodopa occurs through kidney as homovanilic acid  https://lnkd.in/dSM98eRY

Paradoxical psoriasis w/ IL-17 inhibitors? Lit review of 35 (SpA) pts, mostly presenting as palmoplantar pustular and plaque PsO; median 11 weeks after IL-17i. one-third continued IL-17i w/ mostly topical Rx; 2/3 D/C IL-17i, switching to other biologic w/ good outcomes https://buff.ly/4eOdXfb

Paradoxical psoriasis w/ IL-17 inhibitors? Lit review of 35 (SpA) pts, mostly presenting as palmoplantar pustular and plaque PsO; median 11 weeks after IL-17i. one-third continued IL-17i w/ mostly topical Rx; 2/3 D/C IL-17i, switching to other biologic w/ good outcomes https://buff.ly/3We6LSh

An interesting case that I have encountered this week taught me some interesting points. Oral dapsone given for treatment of acne can lead to acquired methemoglobinemia, Presenting symptoms are cyanosis and dyspnea. By examination air entry is clear bilaterally, and no sign can explain the marked desaturation. By investigation viral pneumonia was excluded by CT chest and normal labs. The only clue was given by history which is a reminder that good history taking is a must. Management of this condition is by good supportive care especially oxygen and IV methylene blue. Methylene blue itself should be used cautiously as it's an oxidant and at multiple doses can by itself cause methemoglobinemia. Another interesting fact is that dapsone has a long half life up to 50 hours, so elimination of the drug from the system can take up to 9 days, which can lead to recurrence after initial improvement with methylene blue. One drug that helps increase the metabolism of dapsone is cimetidine.

CBD works indirectly within the endocannabinoid system by unlocking various targets including receptors, ion channels, enzymes and transporters. In other words, CBD creates chatter or cross-talk with numerous molecules within (and outside of) the endocannabinoid system, thereby stimulating these targets to modulate biochemical reactions, or getting them fired up to do their work. In doing so, inflammation is reduced leading to pain reduction, better sleep is induced, and anxiety diminishes. To learn more about Molecular Targets and CBD, read the full article - https://lnkd.in/gnV8Dipj