The Peter Attia Drive’s Post

Just finished listening to this episode of The Drive by Peter Attia. This is a must listen for anyone interested in longevity. So many great nuggets in here including the difference between things that are "proven" longevity accelerators like VO2Max and Muscle Mass/Strength vs. things that are promising but not proven like Rapamycin. I love this quote to demostrate the point “Look, once you’ve got your VO2 max here and your muscle mass here and your strength here, then we can talk about the 37 supplements that you’re interested in taking.” #longevity

In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO₂ max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years. Here’s a glimpse of what we discuss: - The energy balance theory - The importance of VO2 max, muscle mass, and muscular strength for lifespan - How to preserve muscle while trying to lose weight - Fasting as a tool for longevity (and why Peter stopped his fasting protocol) - Using stem cells to treat osteoarthritis or injury - More https://bit.ly/3QtOuNs

Happy to share our latest research paper published in the PNAS journal. Findings from our study: 🧪🩸Integrated cytokine evaluations of saliva and serum showed that the oral host response was distinct from the systemic response. 🦠🧫The hierarchical classification of COVID-19 status and respiratory severity using multiple modalities separately (i.e., microbiome, salivary cytokines, and systemic cytokines) and simultaneously (i.e., multi-modal perturbation analyses) revealed that the microbiome perturbation analysis was the most informative for predicting COVID-19 status and severity, followed by the multi-modal. 👩🔬🧑🔬🔬Our findings suggest that oral microbiome and salivary cytokines may be predictive of COVID-19 status and severity, whereas atypical local mucosal immune suppression and systemic hyperinflammation provide new cues to understand the pathogenesis in immunologically naïve populations. Huge thanks to my collaborators Marcelo Freire, Khaled Altabtbaei, Saadoun Bin-Hasan, Devarajan Sriraman, and Fahd Al-Mulla. The study was funded by J. Craig Venter Institute, Dasman Diabetes Institute, and L'Oréal

"You are as old as your oldest organ" - no, that is not an ad for some exotic transplant rejuvenation clinic but it is in essence what scientists from Stanford described in their recent publication in Nature https://lnkd.in/eY9pWCG4 Their research looked at human blood plasma proteins tied to specific organs to understand organ-specific aging in humans. They studied aging across 11 major organs, estimating organ age across five independent groups of 5,676 adults spanning lifespans. What they found was striking: almost 20% of people show significantly accelerated aging in one particular organ, while only 1.7% show signs of aging in multiple organs. That simply tells you that you are as young as your oldest organ 😀 The implications of accelerated organ aging are serious, with a 20–50% higher risk of mortality observed. Additionally, organ-specific diseases correlate with faster aging of those organs. For example, individuals with accelerated heart aging face a 250% higher risk of heart failure, while accelerated brain and vascular aging are predictive of Alzheimer’s disease (AD) progression. Their models reveal connections between vascular calcification, extracellular matrix alterations, and synaptic protein shedding, all contributing to early cognitive decline. Remarkably, these insights stem from a simple blood draw, showcasing the potential of blood-based biomarkers in understanding aging and disease progression. #aging #bloodtest #proteomics #personalizedmedicine #alzheimersdisease photo source Midjourney

Delighted to announce the publication of my new research paper from Bernal Institute, University of Limerick! Here, we explore the anti-inflammatory effects and mechanisms of dietary polar lipids in context of neuroinflammation and Alzheimer's disease. Thanks to the dedicated efforts of all those involved in this project Andreas Grabrucker, Ioannis Zabetakis, Janelle S., Ann Katrin Sauer, Ronan Lordan, Sushanta Kumar Saha, Katie Shiels and ALEXANDROS TSOUPRAS. #universityoflimerick, #functionalfoods, #inflammation, #alzheimers, #lipids #research Read it here in Lipids in Health and Disease:

🔬📊 Exploring Complexities in Translational Research: Integrating Diet and Disease Models 🌱🧬 We have been into the intricate intersection of cardiovascular complications, uremic models, and cancer. Our work employs diverse diets, including high-fat diets, to simulate various aspects of metabolic syndrome. However, navigating challenges such as accurate diet intake recording, deciphering different animal strains' varied responses to diets, and refining specific procedural methodologies are critical to deriving robust research outcomes. Beyond the technical aspects, we emphasize the pivotal role of the human factor in our research equation. Understanding how individual records influence outcomes is integral to shaping our insights into disease progression and treatment efficacy. Any thoughts on confounding factors? I look forward to sharing more insights from our ongoing studies, which aim to advance medical knowledge and improve patient care. Check out some of our related work in the field. Please feel free to use the following links: Lotfollahzadeh S, et al. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul;73:101744. doi: 10.1016/j.molmet.2023.101744. Epub 2023 May 26. Arinze NV, Yin W, Lotfollahzadeh S, et al. Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease. J Clin Invest. 2022 Jan 4;132(1):e142260. doi: 10.1172/JCI142260. #TranslationalResearch #CardiovascularHealth #MetabolicSyndrome #CancerResearch #ScientificInnovation 🌟 The image relates to the GTT during one of the so-called experiments. Elahe Parsafard Arameh Abbasianchavari Ghazal D.

✨ 🦠 SCRI SPOTLIGHT 🧬✨ Meet Ian Tom! Ian is a nutrition student at Hunter College, currently working in Dr. Jayashri Ghosh's lab at Temple University. Q: What have you been working on in your lab? A: In my lab, I have been focusing on analyzing dietary factors in colorectal cancer patients from various demographic groups. Under the mentorship of Dr. Jayashri Ghosh at the Fels Cancer Institute for Personalized Medicine, Temple University, my work specifically examines four distinct groups: early onset and late onset colorectal cancer patients among African Americans and Caucasian Americans. By studying a wide range of dietary variables, our goal is to uncover potential risk patterns associated with each group and ultimately contribute to developing dietary guidelines aimed at reducing the prevalence of early-onset colorectal cancer.

Great paper from Vadim Gladyshev lab and collaborators !👏👏👏👏👏 #multiomicspapers on 🔥 This research provides valuable insights into the relationship between aging, disease, and environmental factors, with significant implications for understanding and potentially modifying the aging process. ✔️Key Findings - Machine learning applied to plasma proteome data from over 50,000 participants revealed organ-specific aging patterns. - About 18.4% of adults 50+ have at least one organ aging significantly faster than average. - Accelerated organ aging increases all-cause mortality risk by 15-50% over 15 years. - Men are biologically older and age faster than women. - Accelerated organ aging predicts organ-specific diseases, e.g., 250% increased heart failure risk with accelerated heart aging. - Environmental factors influence organ-specific aging rates. ✔️Implications - Chronic diseases represent accelerated organ-specific aging. - Potential for targeted interventions to modify aging processes. - Supports both universal and personalized anti-aging strategies. - Opens avenues for early disease prediction and preventive medicine. #precisionmedicine #agingresearch Thermo Fisher Scientific Olink Proteomics

Today’s #weeklyread is based on a study from scientists at Boehringer Ingelheim and Johannes Gutenberg University, Mainz, who used the Olink® Target 96 Inflammation panel to gain important insights into the inflammatory mechanisms linking obesity and cardiovascular risk. Plasma proteomics were measured in 6662 participants from the population-based Gutenberg Health Study (GHS), and machine learning was used to identify a 21-protein signature associated with obesity. This “obesity-related inflammatory protein signature” (OIPS) was associated with cardiac deaths, major adverse cardiovascular events, and incident coronary artery disease, independent of clinical covariates and established risk instruments, and was successfully replicated in an independent validation cohort. Pathway analysis for the OIPS proteins showed enrichment for pathways related to chemokine activity, TNF receptor binding or growth factor receptor binding, providing potential insights into the underlying pathomechanisms involved. The authors concluded, “The newly identified OIPS proves to be a promising tool for identifying individuals with overweight and obesity who are at higher risk for all-cause mortality and adverse cardiovascular outcomes". Read the article: https://bit.ly/3KeYUwW #proteomics #biomarkers #obesity #inflammation

How #proteomics can decipher the #aging trajectory! Researchers in the lab of Tony Wyss-Coray, PhD, at Stanford University study aging and its effects on the human body to understand how our bodies – and even specific organs – change molecularly with age to address the global disease burden associated with aging and support the development of preventive medicine and improved patient care. The lab utilized the SomaScan® Platform as one of the tools to bind target proteins with high specificity to enable the assessment of thousands of human proteins in plasma. This landmark study has been replicated across a wide variety of cohorts (and species) and has transformed the way we view the aging trajectory. Findings have been cited nearly 400 times in other high-impact journals and the paper has 54,000 downloads! The novel findings were published and featured as the cover article in Nature (December 2023): Organ aging signatures in the plasma proteome track health and disease (https://lnkd.in/d3BxUugR) #DiagnosticMarkers #MachineLearning #PredictiveMarkers #PrognosticMarkers #ProteomeInformatics