The Tadpole Experiment’s Post

Around 10 years ago I graduated in medical nanotechnology from SBMU, Tehran, Iran. I was working on targeted gene delivery to the brain as one of the pioneers in nano medicine in Iran. After three years of hard studying and working, eventually I published my first paper in drug/gene delivery field entitled "Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by SRL peptide for targeted gene delivery to the brain" https://lnkd.in/dTybh7nH and after that, my second paper accepted "SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin" PMCID: PMC5316243PMID: 28243262. A great lesson I have learned is, more important than what you work on is how much time you spend to learn and design an experiment!! It means the value of your work is determined at your first step: design of experiment with highest knowledge in the field. So, more studying more learning!

𝐎𝐫𝐠𝐚𝐧 𝐎𝐧 𝐂𝐡𝐢𝐩 𝐌𝐚𝐫𝐤𝐞𝐭 𝟐𝟎𝟐𝟒-𝟐𝟎𝟑𝟐. 𝐆𝐥𝐨𝐛𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐑𝐞𝐩𝐨𝐫𝐭 Organ-on-Chip (OOC) technology represents a groundbreaking advancement in biomedical engineering, particularly within the realm of bio-MEMS research. These multi-channel 3-D microfluidic cell culture chips mimic the activities, mechanics, and physiological responses of entire organs and organ systems, offering a novel model for in vitro multicellular human organism studies. By merging labs-on-chips (LOCs) with cell biology, OOCs enable the exploration of human physiology in organ-specific contexts, potentially revolutionizing drug development and toxin testing by eliminating the need for animal subjects. This technology not only integrates various cell types but also incorporates engineering features like guided spatial cell confinement and the integration of sensors and microfluidic channels. Its primary objective is to recreate three critical aspects of human physiology: the multicellular vascular or epithelial interfaces of organs (e.g., blood vessel networks, lungs, and gut), tissue-level organization of parenchymal cells (e.g., liver, heart, skeletal muscle, and tumors), and the systematic interaction of multiple organs (e.g., drug absorption, distribution, metabolism, and elimination involving the gut, circulation, liver, and kidney). The Organ-on-Chip market is segmented by type and end-user, with accurate forecasts for consumption value provided for the period 2024-2032. 𝐓𝐨 𝐊𝐧𝐨𝐰-𝐓𝐡𝐞 𝐆𝐥𝐨𝐛𝐚𝐥 𝐒𝐢𝐳𝐞 𝐀𝐧𝐝 𝐃𝐞𝐦𝐚𝐧𝐝 𝐎𝐟 𝐓𝐡𝐞 𝐎𝐫𝐠𝐚𝐧 𝐎𝐧 𝐂𝐡𝐢𝐩 𝐌𝐚𝐫𝐤𝐞𝐭. 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/dgd4er9y *𝗕𝘆 𝗧𝘆𝗽𝗲: Brain-on-a-chip, Liver-on-a-chip, Kidney-on-a-chip, Lung-on-a-chip, Heart-on-a-chip, Intestine-on-a-chip, Vessel-on-a-chip, Other Organs. *𝗕𝘆 𝐄𝐧𝐝 𝐔𝐬𝐞𝐫: Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Cosmetics Industry, Others. *𝗕𝘆 𝗥𝗲𝗴𝗶𝗼𝗻𝘀: North America, Europe, Asia-Pacific, South America, Middle East & Africa *𝗕𝘆 𝗞𝗲𝘆 𝗣𝗹𝗮𝘆𝗲𝗿𝘀: MIMETAS, TissUse GmbH, Valo Health, CN BIO INNOVATIONS LIMITED, Hesperos Inc., Cherry Biotech #biomedicalengineering #organonchip #biomems #microfluidics #cellculture #labs-on-chips #cellbiology #drugdevelopment #toxintesting #animaltesting #physiology #tissueengineering #sensors #bioengineering #organoids #humanonachip #medicalresearch #biotechnology #innovation #linkedin

𝐍𝐀𝐍𝐎𝐌𝐀𝐓𝐄𝐑𝐈𝐀𝐋𝐒 𝐈𝐍 𝐓𝐇𝐄𝐑𝐀𝐆𝐍𝐎𝐒𝐈𝐒: 𝐁𝐑𝐈𝐃𝐆𝐈𝐍𝐆 𝐆𝐄𝐍𝐎𝐌𝐈𝐂𝐒 𝐀𝐍𝐃 𝐍𝐀𝐍𝐎𝐓𝐄𝐂𝐇𝐍𝐎𝐋𝐎𝐆𝐘 A groundbreaking review in the Elsevier International Journal of Biological Macromolecules, titled "Nanomaterials for detection of biomolecules and delivering therapeutic agents in theragnosis," heralds a new chapter in biomedical research. Authored by a stellar team of scientists - Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, BuHyun Youn, Jung Sub Lee, Muthuchamy Nallal, and Kang Hyun Park - this paper is a testament to the power of collaborative international research in pushing the frontiers of medical technology. Their combined expertise from leading institutions across India and South Korea exemplifies the potential of global collaboration in scientific innovation. 𝑼𝒏𝒅𝒆𝒓𝒔𝒕𝒂𝒏𝒅𝒊𝒏𝒈 𝑵𝒂𝒏𝒐𝒎𝒂𝒕𝒆𝒓𝒊𝒂𝒍𝒔 𝒊𝒏 𝑻𝒉𝒆𝒓𝒂𝒈𝒏𝒐𝒔𝒊𝒔 The review elegantly illustrates the concept of theragnosis, a revolutionary approach that combines therapy and diagnosis, leveraging the unique properties of nanomaterials. It explains how nanoparticles, mere billionths of a meter in size, can be engineered to simultaneously act as drug delivery vehicles and diagnostic tools. This dual functionality is particularly impactful in treating complex diseases like cancer, where nanoparticles can deliver drugs directly to the tumor while providing real-time imaging for monitoring treatment efficacy. This section of the review makes the sophisticated world of nanotechnology accessible, explaining its significance in a language that resonates with both scientific and non-specialist audiences. 𝑮𝒆𝒏𝒐𝒎𝒊𝒄𝒔: 𝑻𝒉𝒆 𝑮𝒂𝒕𝒆𝒘𝒂𝒚 𝒕𝒐 𝑷𝒆𝒓𝒔𝒐𝒏𝒂𝒍𝒊𝒛𝒆𝒅 𝑴𝒆𝒅𝒊𝒄𝒊𝒏𝒆 A key highlight of the review is its focus on genomics - the study of an organism's complete set of DNA. Genomics plays a pivotal role in theragnosis by providing detailed genetic information that helps in identifying specific drug targets and disease markers. The review explains how this information is crucial in designing tailored treatments for individuals, moving away from a 'one-size-fits-all' approach to a more personalized form of medicine. The clear and concise explanation of genomic principles in the context of theragnosis is both informative and insightful, offering readers a comprehensive understanding of this complex field. 𝑰𝒏𝒏𝒐𝒗𝒂𝒕𝒊𝒐𝒏𝒔 𝒊𝒏 𝑵𝒂𝒏𝒐𝒑𝒂𝒓𝒕𝒊𝒄𝒍𝒆 𝑫𝒓𝒖𝒈 𝑫𝒆𝒍𝒊𝒗𝒆𝒓𝒚 The review delves deep into the latest innovations in nanoparticle-based drug delivery systems. It highlights various types of nanoparticles, such as liposomes and polymeric nanoparticles, explaining their roles and benefits in drug delivery. The review illustrates how these tiny carriers improve drug efficiency, reduce side-effects, and provide controlled drug release. #Theragnosis #NanotechnologyInHealthcare #GenomicsRevolution #PersonalizedMedicine

The future of laboratories in healthcare biotechnology is set for transformative advancements driven by genomic and proteomic innovations. Laboratories will increasingly enable personalized medicine through comprehensive genomic profiling, optimizing treatment specificity and efficacy. Innovations in stem cell research and biomaterials will facilitate regenerative therapies for repairing damaged tissues, while rapid, portable diagnostic assays will enhance real-time disease monitoring, improving clinical decision-making. The integration of artificial intelligence and machine learning will refine laboratory workflows, enabling the extraction of complex biological insights from extensive datasets. Moreover, laboratories will play a critical role in the production and quality control of advanced therapies, including CRISPR-based gene therapies and CAR-T cell therapies. Collaborative efforts among laboratories, academic institutions, and industry stakeholders will foster an open innovation ecosystem, expediting the translation of discoveries into clinical applications. Ultimately, the evolution of laboratories in healthcare biotechnology will prioritize precision and patient-centered care, significantly enhancing therapeutic outcomes. #HealthcareBiotechnology #ArtificialIntelligence #MachineLearning #CRISPR #CAR_T #BiotechInnovation #Therapeutics #ClinicalResearch #LaboratoryScience #HealthTech #LondonBiotechnologyShow #LBS25

🌟Pioneering Advances in Biotechnology: A Glimpse into the Future of Medical Technology🌟 Recent research in biotechnology has revealed transformative potential for the medical technology industry. Groundbreaking studies in gene editing, bioengineering, and regenerative medicine are pushing the boundaries of what’s possible, offering new solutions to some of healthcare’s most pressing challenges. One of the most promising areas is the advancement of CRISPR technology, which has shown remarkable potential in treating genetic disorders. Recent experiments have demonstrated the ability to precisely edit genes, paving the way for targeted therapies that could cure previously untreatable conditions. This technology is rapidly moving from the lab to clinical trials, signaling a future where personalized medicine could become a reality. In parallel, innovations in biomanufacturing are reshaping how biologics are produced. New techniques in cell culture and bioengineering are making the production of complex biological molecules more efficient and scalable. This is crucial as the demand for biologics grows, requiring more robust and adaptable manufacturing processes. These advancements are expected to reduce costs and increase accessibility, making cutting-edge treatments available to a broader patient population. Another exciting development is in the field of regenerative medicine. Researchers are making significant strides in tissue engineering and stem cell therapies, with the potential to repair or replace damaged tissues and organs. This could revolutionize treatment for a wide range of conditions, from traumatic injuries to degenerative diseases, offering new hope for patients worldwide. These research findings highlight the intersection of biotechnology and medical technology as a fertile ground for innovation. The integration of these advanced technologies into healthcare systems will require collaboration across industries, with input from experts in manufacturing, product development, and clinical application. The role of strategic partnerships and expert networks will be critical in translating these scientific breakthroughs into real-world solutions that benefit patients globally. As biotechnology continues to evolve, staying informed and engaged with these developments will be essential for anyone involved in medical technology. The future is being shaped by these innovations, and those who understand and adapt to these changes will be at the forefront of the next wave of healthcare transformation. #Biotechnology #MedicalTechnology #Innovation #Research #HealthcareAdvancement #FutureOfHealthcare

💎💎💎Whatsapp!! 💎💎💎Adapting Immortalized hMSCs to Suspension Culture Today, the #therapeutic use of #extracellular #vesicles (#EVs) typically involves human #mesenchymal stromal cells (#hMSCs). As more is learned, though, scientists are starting to think that #hMSCs may be replaced by EVs interacting with the cell #secretome. As such, they function like protocells but are less #immunogenic, making them better candidates than cell therapy for certain applications, like fibrosis treatment. Before that can happen, EVs need a scalable manufacturing system. Adapting immortalized hMSCs to #suspension_culture “solves two main problems associated with EV manufacturing,” Qasim Rafiq, PhD, professor of bioprocess engineering and vice dean (health) in the faculty of engineering sciences, University College London (UCL), tells GEN. “#Immortalization ensures consistency across batches, and the suspension method increases overall process productivity by manufacturing a higher amount of EVs on a #volumetric basis. “If proven clinically relevant,” Rafiq says, “this cell line and its respective EVs have the potential to completely change the fundamental approach in the vast #majority of #clinical_trials relying on #donor-derived, #adherent hMSCs.” The human #telomerase #reverse #transcriptase ( #hTERT) immortalized human mesenchymal stromal cells (hMSCs) Rafiq and colleagues developed, called suspension hMSCs (S-hMSCs), “eliminate the need for #microcarriers or other matrices to support adherent cell growth,” they report. In this study, S-hMSCs doubled in about 55 hours. The cells retained approximately 90 percent of the CD73 and CD105 expression levels, and, “the CD90 receptor [was] #downregulated during the #suspension adaptation process.” Meanwhile, the #transcripts coding for CD44, CD46, and CD47 were upregulated compared to those in #adipose tissue-derived-hMSCs and hTERT-hMSCs. The S-hMSCs generated EVs that averaged 150nm in size and bore the markers CD63, CD81, and TSG101. The negative marker, calnexin, was not expressed. ➡ 💎 You can find more pieces of work by clicking here. https://lnkd.in/eSG67K5G https://lnkd.in/dB3s88ei 

Check out the latest report from IMIR Market Research Pvt. Ltd. on the 𝗦𝗶𝗻𝗴𝗹𝗲-𝗖𝗲𝗹𝗹 𝗦𝗲𝗾𝘂𝗲𝗻𝗰𝗶𝗻𝗴 𝗠𝗮𝗿𝗸𝗲𝘁 Outlook and Geography Forecast till 2028 Don't miss out on this opportunity to stay informed about the latest trends in the industry.   Single-Cell Sequencing Market Size, Share & Trends Analysis Report By Product (Consumables, Reagents, Assay Kits, Instruments, Microscopes, Hemocytometers, Flow Cytometers, NGS Systems, PCR Systems, High Content Screening Systems, Cell Microarrays, Single Live Cell Imaging, Automated Cell Counters), By Technology (Flow Cytometry, Next-generation Sequencing, Polymerase Chain Reaction, Microscopy, Mass Spectrometry, Others), By Workflow (Single Cell Isolation, Sample Preparation, Genomic Sequencing), By End-use (Academic & Research Laboratories, Biotechnology & Pharmaceutical Companies, Hospitals & Diagnostic Laboratories, Cell Banks & IVF Centers, Others), By Application (Research Applications, Oncology, Immunology, Neurology, Stem Cell, Others, Medical Applications, Non-invasive Prenatal Diagnosis, In-vitro Fertilization, Circulating Tumor Cell Detection), COVID-19 Impact Analysis, Regional Outlook, Growth Potential, Price Trends, Competitive Market Share & Forecast, 2022 - 2028   📚 𝐆𝐞𝐭 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐚𝐭 𝐝𝐢𝐬𝐜𝐨𝐮𝐧𝐭𝐞𝐝 𝐩𝐫𝐢𝐜𝐞:👇 https://lnkd.in/dShPsEDw   📚𝐓𝐨𝐩 𝐌𝐨𝐫𝐞 𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬 𝐀𝐫𝐞::👇 Centro Nacional de Análisis Genómico (CNAG) Biolidics Limited (Formerly known as Clearbridge BioMedics) Cleveland Clinic Cold Spring Harbor Laboratory Columbia Genome Center Covance CYTENA Cytomos Cytosurge AG Integrated DNA Technologies Dolomite Atrandi Biosciences | Droplet Genomics Duke Molecular Physiology Institute Earlham Institute Eldan Epinomics - Part of 10x Genomics ExosomePlus FlowJo Fluidigm Sciences, Inc. Fulgent Genetics Functional Genomics Center Zurich GenapSys Genentech Genetic Resources Core Facility (GRCF) GENEWIZ from Azenta Life Sciences Génome Québec Genome Technology Access Center @MGI GenomeScan Genuity Science  

𝐓𝐡𝐞 𝐄𝐮𝐫𝐨𝐩𝐞 𝐈𝐧𝐝𝐮𝐜𝐞𝐝 𝐏𝐥𝐮𝐫𝐢𝐩𝐨𝐭𝐞𝐧𝐭 𝐒𝐭𝐞𝐦 𝐂𝐞𝐥𝐥 (𝐢𝐏𝐒𝐂) 𝐦𝐚𝐫𝐤𝐞𝐭 𝐬𝐢𝐳𝐞 𝐢𝐬 𝐞𝐱𝐩𝐞𝐜𝐭𝐞𝐝 𝐭𝐨 𝐫𝐞𝐚𝐜𝐡 𝐔𝐒𝐃 𝟏,𝟏𝟏𝟏.𝟗𝟕 𝐌𝐢𝐥𝐥𝐢𝐨𝐧 𝐛𝐲 𝟐𝟎𝟑𝟐,𝐞𝐱𝐡𝐢𝐛𝐢𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐂𝐀𝐆𝐑 𝐨𝐟 𝟗.𝟑% 𝐝𝐮𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐟𝐨𝐫𝐞𝐜𝐚𝐬𝐭 𝐩𝐞𝐫𝐢𝐨𝐝. 𝙁𝙤𝙧 𝙈𝙤𝙧𝙚 𝙍𝙚𝙥𝙤𝙧𝙩 𝘿𝙚𝙩𝙖𝙞𝙡𝙨, 𝙑𝙞𝙨𝙞𝙩: https://lnkd.in/d-HCyQT7 The increased interest in personalized medicine and the surge in healthcare expenditures are all factors that can contribute to the growth of this market. However, certain factors, such as the high cost associated with stem cell therapies, are hindering the #growth of the European induced pluripotent stem cells (iPSCs) market. Currently, stringent rules and regulations surrounding iPSCs and the issue of genomic instability are key challenges. #ipsc #stemcells #europe #biotechnology #regenerativemedicine #celltherapy #medicalresearch #biotech #lifesciences #stemcellresearch #genetherapy #healthinnovation #medicaladvancements

Exocobio Exosomes are nano-sized vesicles ranging from 30-200nm that are present in eukaryotic fluids and facilitate a diverse range of cellular functions. They transfer DNA, RNA, and proteins to other cells, thereby altering the function of the targeted cells. Because of their far ranging potential, exosomes can be commercialized as therapeutic agents, diagnostic tools, and cosmeceuticals. Today, a surging number of companies are developing exosome-based products and technologies. Exocobio Exosomes have technology of isolation & purification technology of 0.1~0.5% Purest exosomes from stem cell conditioned media. #Exocobio #Exosomes #ASCE #HRLV #Nanoparticles #PurestExosomes #Rejuvenation #Hairgrowth #Growthfactors #SkinRejuvenation #Leadermedicalsystems #Regenrativemedicine

Nanotechnology in Medicine: Tiny Solutions for Big Problems Nanotechnology is revolutionizing the medical field by introducing innovative ways to address some of the most pressing health challenges of our time. The use of nanotechnolog... [...] #Cancer #Drugresistancebacteria #Drugs #Healthcare #Medicine #Nanotechnology #Precisediagnostics #Therapeuticagents #Toxicity Read more... https://lnkd.in/dUzXnf7X