Thue Schwartz’s Post

Delving into new territories demands state-of-the-art equipment, and we're honored to be at the forefront. Introducing the Hamilton Company Microlab STAR coupled with a SCIEX 5500+ LC-MS/MS system, a revolutionary robotic solution revolutionizing sample handling with unprecedented speed and precision. The National Metabolomics Platform (NMP), trailblazing users of this technology opens doors to limitless possibilities. As the exclusive distributors of Hamilton and Sciex in Sub-Saharan Africa, the SEPARATIONS team ensures seamless access to technical support and customized solutions. Whether automating in-house methodologies or employing kit-based LC-MS/MS solutions from Chromsystems, we're committed to empowering your research endeavors. Eager to witness a lab in action? Dive into our latest YouTube video in collaboration with National Metabolomics Platform below https://lnkd.in/d45aje4A showcasing the prowess of our advanced equipment specifically used for diagnosis of Rare Diseases. Join us on the journey of innovation and scientific discovery with DIPLOMICS (Distributed Platform in Omics) (Distributed Platform in Omics). #Metabolomics #Research #Innovation #Science #Technology #SubSaharanAfrica #Hamilton #Sciex #NationalMetabolomicsPlatform #separations #chromsystems

I am delighted to share the #publication of my first-author research article, titled "Comparative Molecular Docking Studies of Selected Phytoconstituents on the Dopamine D3 Receptor (PDB ID: 3PBL) as Potential Anti-Parkinson’s Agents." I extend my sincere gratitude for the collaboration of co-authors Pallavi Dikshit and Namrata Kumari, as well as for the invaluable guidance provided by Manik Ghosh Sir. Parkinson’s disease is an idiopathic neurodegenerative disorder which is characterized by the degeneration of the neurons of substantia nigra, a part of the midbrain, regulating motor movement. Levodopa is a commonly prescribed medication for managing Parkinson's disease. Considering Levodopa as the standard, ten phytoconstituents were evaluated in this study through molecular docking against the dopamine D3 receptor to seek out potential inhibitors. Among them, Vasicol stood out with its favorable docking score and low toxicity profile, suggesting its potential as a promising candidate for the treatment of Parkinson's disease. #researcharticle #publication #parkinson #docking #medicinalchemistry #chemistry #journal #mdpi #chemistryproceedings #drugdiscovery #drugdevelopment #greenchemistry #pharmaceuticalindustry #pharmacy #pharmaceuticalchemistry #cadd #ShrimantiChakraborty

Orthogonal hit confirmation at Edelris by Affinity Selection – Mass Spectrometry (ASMS) HIGH CONFIDENCE RESULTS WITH ACCURATE & REPRODUCIBLE DATA As ASMS do not require tags nor immobilizations, thereby minimizing conformational distortion, it is an advantageous technology for the orthogonal confirmation of hits identified from other screening methods. Our biochemists select the optimal method (ALIS or parallelized plate-based methods) for each of your protein- or RNA targets, ensuring high throughput generation of accurate and reproducible data within a quick turn-around time. Our team adapts to your customized experiments (addition of co-factors, comparison between wild type and mutant targets, sub-domain profiling). We also design your competition assays if you need insight into the specific target-ligand binding modes. Do not hesitate to contact us to help you design the compound profiling strategy that fits your project #drugdiscovery #biochemistry #lifesciences #innovation  #medicinalchemistry #research

Amazing work done with our inspirational customers National Metabolomics Platform and their partner DIPLOMICS (Distributed Platform in Omics) . Thank you for making SEPARATIONS your trusted partner. Having state of the art sample automation from Hamilton Company preparing and injecting samples straight onto SCIEX mass spectrometry systems is truly ground breaking and opens up so many #diagnostic opportunities for many #clinical #pathology #pathologylab labs out there. Our sample preparation kits from Chromsystems really make this a winning combination through cutting edge technologies. The cherry on the cake would be to also automate that card punching with our state-of-the-art Hamilton EasyPunch platforms. 😉 To all those struggling to get the right #labautomation and #analytical partner, do not hesitate to call us. The struggle does not have to be real, just choose your partner wisely. Choose SEPARATIONS 👊 #metabolomics #innovation #technology #health #raredisease #science #SubSaharanAfrica #Hamilton #Sciex #Chromsystems #separations #NationalMetabolomicsPlatform

The work of my PhD has been finally published on the Journal of Medicinal Chemistry! The project was based on the investigation of the mGlu7 receptor NAM XAP044 to discover its binding mode in the Venus Flytrap Domain of mGlu7R and to synthetize more potent analogs. The combination of SAR, pharmacology and molecular modelling studies allowed to disclose a novel inhibitory site in the mGlu7R VFT domain. Furthermore, more potent analogs of XAP044 have been discovered. All these results give us a deeper knowledge of the mGlu7 receptor mechanism and their role in future drug discovery! Thanks to all the people who worked on this project: Alexandre Cabayé, Isabelle Brabet, Ralf Glatthar, Amelie Tora, Cyril Goudet, Hugues-Olivier Bertrand, Anne Goupil-Lamy, Peter J. Flor, Jean-Philippe Pin, Isabelle McCort-Tranchepain and Francine C. Acher. https://lnkd.in/eVSw5gra

Our paper on metabolite identification and characterization of #Ostarine, a selective androgen receptor modulator commonly used as doping agent, is available at; https://lnkd.in/d-Kdj4vm, part of the special issue on Molecular Markers in Forensic Science as Elements of Evidence. Kintz and Gheddar early demonstrated a case of cross-contamination where the athletes involved were suspended, highlighting perhaps why "contextual interpretation" may be important in certain cases, although, that could be a slippery slope if examiner bias starts to creep in. Find Kintz & Gheddar, 2024 here: https://lnkd.in/dGAD8PjP #ToxWatch #CleanSports #Forensics

our new paper reveals novel substates of the GTP-bound N-Ras oncogenic protein

Inflammation modulation: simultaneous target validation and hit finding using a chemo-proteomic approach on SLC15A4. Using a similar methodology to that used to target transcription factors, (https://lnkd.in/d_uPQU7X), another team from the chemistry Dpt. of the Scripps Research Institute, now shows engagement and modulation of SLC15A4, a12-transmembrane (TM) domain protein. (Chiu et al.; Nature chem. biol.  January the 8th 2024). Their low µM compounds do bind SLC154A4 and inhibit the downstream functions responsible for inflammation. Here again, the compounds are clearly no drug yet. Nevertheless, this approach, as the authors rightly claim, allows robust target dentification, validation and experimental druggability assessment with the added benefits of providing chemical probes and even possibly starting points highlighting the strength of the method.   #drugdiscovery #inflammation #chemoproteomics #membraneprotein #slccarriers #ScrippsResearch #SLC15A4 Below: PDB  8WX5, Cryo-EM structure of human SLC15A4 in complex with TASL.

#callforreading #recommendations in Methods and Protocols MDPI Title: pH and NaCl Optimisation to Improve the Stability of Gold and Silver Nanoparticles’ Anti-Zearalenone Antibody Conjugates for Immunochromatographic Assay Authors: Thasmin Shahjahan, Bilal Javed, Vinayak Sharma and Furong Tian are from Technological University Dublin Read and Download for #free at: https://lnkd.in/gF2FPNJK #methods #protocol #article #pH #nanoparticles #assay #antibodyconjugates #biosensing #bioreporter #flowdevices

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