Tourmaline Bio’s Post

💡There is still a lot to learn and gaps in knowledge remain more than 25 years after the EU market authorization of #clopidogrel in July 1998, which followed the results of #CAPRIE in The Lancet (https://lnkd.in/dnzy9zQY) ✍️To tie in here, see the excellent summary on „The year in cardiovascular medicine 2023: the top 10 papers in thrombosis and antithrombotic treatment“ by Felicita Andreotti, Michelle O'Donoghue, MD MPH and Jur ten Berg …including studies on #SAPT (aspirin vs. clopidogrel), shortened #DAPT and our meta-analysis on guided vs. potent P2Y12 inhibitor therapy for #ACS & #PCI in European Heart Journal (https://lnkd.in/dp_Y-UWq) by Mattia Galli , Davide Capodanno , Giuseppe Biondi Zoccai , Roxana Mehran , C. Michael Gibson, M.S., M.D. , Filippo Crea , Dominick Angiolillo , Francesco Franchi et al. https://lnkd.in/dkWMKGtQ #PCI #Platelets #Personalized Medicine

The recent CVOT Summit Report 2023 shed light on groundbreaking outcomes trials in cardiovascular, kidney, and metabolic health. Discussions highlighted advancements in managing major adverse cardiovascular events and obesity-related heart failure. The summit also explored innovative strategies for diabetes, chronic kidney disease, and obesity treatment. Emphasizing inclusivity in clinical trials and patient-centered care, this report is a must-read for healthcare professionals seeking the latest developments in managing diabetes and associated comorbidities. #CVOTSummit #Cardiology

The Special Issue of Dr. Ramoji Kosuru "Molecular Signaling Mechanisms in Cardiovascular Diseases" has been published in #FBLjournal at https://lnkd.in/g5Mfcv-Q In this research topic, we invite Original Research or Review articles that explore the molecular mechanisms behind heart failure and highlight the interplay between various signaling systems, along with potential treatments for cardiovascular medicine. In addition, we emphasize the influence of current therapys, such as natural substances or preexisting medications, on these molecular pathways and their potential for the advancement of heart failure therapy. #heart_failure #cardiovascular_illness #myocardial_remodeling #myocyte_loss #fibrosis #autophagy #metabolic_abnormalities #mitochondrial_dysfunction #inflammatory_stress #oxidative_stress #cardiovascular_pathologies

I am thrilled to share that our manuscript, "Long-term effect of mavacamten in obstructive hypertrophic cardiomyopathy," has been accepted in the European Heart Journal. I feel fortunate to have contributed to this important research advancing cardiovascular research. #BMSEmployee #CardiovascularResearch #EHJ

In this 10th article of #NMRinClinicalResearch, a Bruker Avance IVDr* spectrometer enabled clinical researchers to measure LDL #cholesterol as it is an important contributor to the risk of coronary heart disease, and its measurement is central to evaluating the effects of lipid-modifying therapies. Several ‘#LDL-cholesterol’ assays exist but their methodologies differ, leading to between-assay heterogeneity in values of ‘LDL cholesterol’. There is a need for awareness of the potential implications. Read the article: https://lnkd.in/drgfTxxN Learn more about Bruker Avance IVDr and NMR* clinical research solutions and applications: https://lnkd.in/d8DTxDuW Springer Nature Group *Bruker NMR Instruments are for Research Use Only. Not for Use in Clinical Diagnostic Procedures. #NMR #Cardiology

"Longest weight-loss medication study conducted to date"... It's exciting to see the results of this study and the impact these medications can have when they are properly placed into a member's treatment plan. Wondr Health takes a highly conservative, thoughtful approach into prescribing these medications. Always matching members to the right medication and continually supporting them with best-in-class behavior change methodologies and superior clinical oversight. #Weightmanagement #GLP1s #obesitymanagement #behaviorchange #medicationmanagement

"Exciting new research published in the New England Journal of Medicine (@NEJM) reveals insightful findings on Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. Check out the full article here:https://lnkd.in/gNjW_GNj . #NEJM #MedicalResearch #Healthcare #NewDiscoveries"

🔊 Original Research --  Volume 24 / Issue 9 (2023) - Reviews in Cardiovascular Medicine 📔 Discordance of Circulating Non-HDL Cholesterol with LDL Cholesterol Concerning Long-Term Prognosis in Statin-Treated Individuals with Acute Coronary Syndrome and Previous Coronary Artery Bypass Grafting Undergoing Percutaneous Coronary Intervention 🔗 https://lnkd.in/gH2m69uQ #CardiovascularResearch #NonHDLCholesterol #LDLCholesterol #AcuteCoronarySyndrome #Statins #PercutaneousCoronaryIntervention #CABG

We'll be presenting new data from our Phase 3 LIBerate 004 study at the American College of Cardiology 2024 (#ACC24). The results demonstrate Lerodalcibep’s long-term impact on LDL-C, a robust predictor of future cardiovascular risk events, in patients with heterozygous familial hypercholesterolemia on background stable lipid-lowering therapy. https://lnkd.in/gNHk_fkx

Current Outcomes after Revascularization for #coronary Very Late #stentthrombosis Read more at Cardiovascular Innovations and Applications #journal 👉 https://lnkd.in/eG4KKmJt #thrombosis #coronaryarterydisease #RiskFactors #OpenAccess #openaccessjournal ScienceOpen Scopus: an eye on global research #CVIAJournal