Transcenta’s Post

Today Clene Nanomedicine, Inc. presented new data from the HEALEY-ALS Platform trial that supports #CNMAu8 efficacy at the 2024 #ENCALS meeting in Stockholm, Sweden. The data shows the drug’s performance during the randomized, double-blind portion of the trial through the long-term, open-label extension. Key highlights of the presentation include long-term survival benefit with CNM-Au8 30 mg treatment compared to PRO-ACT propensity-matched controls, and continued decline in plasma neurofilament light biomarker levels with CNM-Au8 treatment. See more details here: https://bit.ly/3VsqpZ2 #EndALS #ENCALS

What makes exosomes crucial in #diagnostics? Exosome technology is transforming #healthcare, #drugdelivery, and diagnostics. These nanoscale vesicles enhance targeted therapies with bioengineered precision, carrying RNA, proteins, and drugs directly to specific cells. With advanced purification and imaging techniques, exosomes yield high-quality data, opening new pathways in #precisionmedicine and making them promising biomarkers for early disease detection. Click here to know more:  https://lnkd.in/dxZYJjuJ  Key Players:  Danaher Corporation Hologic, Inc. FUJIFILM Holdings Corporation Lonza  Miltenyi Biotec  Bio-Techne   QIAGEN  Thermo Fisher Scientific RoosterBio Inc. #RDive #ExosomeTechnology #TargetedTherapy #HealthcareInnovation #Bioengineering #CellCommunication #Biomarkers #MedicalBreakthroughs  

😎 It's tomorrow! Don't miss the webinar "Drug Response Profiling of Primary Colorectal Tumor Models using spheroONE Pu·MA System EC". This webinar is a collaborative effort between PFI, MatTek Life Sciences, SCIENION, and Cellenion. 🚀🔬 Primary tumoroids are sorted & dispensed into flowchips for drug testing using phenotypic assays. Automated compound incubation and viability staining lead to consistent reproducible high-quality data. This platform is a valuable tool in a wide range of research areas enabling multiplex disease modeling, drug discovery and personalized medicine. 📅 Date: May 29, 2024 🕒 Time: 8 am PDT / 11 am EDT / 5 pm CET 📍 Register here: https://lnkd.in/grHujeWu Register now! #webinar #spheroids #organoids #tumoroids #3dcellularmodels #flowchips #microfluidics #drugtesting #automation

🧬 The Importance of Immunodetection Reagents & Substrates in Research 🧬 Immunodetection reagents and substrates are pivotal in the field of biomedical research. These tools enable the precise detection and quantification of proteins, facilitating breakthroughs in diagnostics, therapeutics, and disease understanding. From primary and secondary antibodies to chromogenic and chemiluminescent substrates, they play a crucial role in various assays like ELISA, Western blotting, and immunohistochemistry. Understanding and utilizing these reagents effectively can lead to significant advancements in medical science. #BiomedicalResearch #Immunodetection #HealthcareInnovation #LifeSciences #AladdinScientific Aladdin Scientific: https://lnkd.in/gmZe2sd7 Aladdin official：https://lnkd.in/gdZRkbhS

🧬 The Importance of Immunodetection Reagents & Substrates in Research 🧬 Immunodetection reagents and substrates are pivotal in the field of biomedical research. These tools enable the precise detection and quantification of proteins, facilitating breakthroughs in diagnostics, therapeutics, and disease understanding. From primary and secondary antibodies to chromogenic and chemiluminescent substrates, they play a crucial role in various assays like ELISA, Western blotting, and immunohistochemistry. Understanding and utilizing these reagents effectively can lead to significant advancements in medical science. #BiomedicalResearch #Immunodetection #HealthcareInnovation #LifeSciences #AladdinScientific Aladdin Scientific: https://lnkd.in/g9eeGF8g

In modern biomedical research, the utilization of peptide libraries has become instrumental in the discovery of novel therapeutics, diagnostics, and research tools. The significance of advanced peptide library screening techniques, focusing on the capabilities of 7 and 12 Phage Display Peptide Libraries, along with the indispensable services provided by Peptide Library Panning and Premade Phage Display Peptide Library Screening Services. By examining the process of peptide library construction, screening, and the emergence of targeted peptide screening technologies, this article underscores their pivotal role in accelerating peptide-based research and development. https://lnkd.in/gBjZnGUa #BiomedicalResearch #PeptideLibraries #NovelTherapeutics #Diagnostics #ResearchTools #PhageDisplay #PeptideLibraryScreening #PeptideLibraryPanning #PremadePeptideLibraries #ScreeningServices #PeptideLibraryConstruction #kmdbioscience

The discovery that really made FACS and flow cytometry a laboratory and clinical standard was the production of hybridomas by Kohler and Milstein in 1975. Read the blog to see how the combined use of monoclonal antibody technology and FACS increased the power of cell analysis. https://bit.ly/43MIHrD #FactsaboutFACS #Flowcytometry #FACS #BDBiosciences

🔬Discover the revolutionary 3D perfusion hollow fiber bioreactors from FiberCell Systems Inc. that are transforming cell culture and research. These bioreactors enable in vivo-like cell growth, fostering complex cellular interactions over extended periods. Ideal for co-cultivation, 3D modeling, and parasitology research, they offer unmatched benefits for various applications, including blood-brain barrier models and monoclonal antibody production. 🔍 Explore the full potential of these bioreactors and how they can enhance your research. 👇 Read the full news item via the link in comments #CellCulture #Bioreactors #ResearchInnovation #FiberCellSystems

In our latest breakthrough, we explored the delivery of mRNA to human NK cell lines without using the traditional electrophoresis buffer (EP buffer), instead opting for PBS and Normal saline. Surprisingly, our results revealed no significant difference in cell survival and transfection efficiency compared to the conventional EP buffer. This technological advancement is a crucial discovery that can provide a fair advantage to many developing cell therapeutic companies. We anticipate significant advantages not only in terms of the cost of the traditional EP buffer itself but also in the simplification of the process, leading to enhanced patient convenience and cost-effectiveness when compared to the necessity of using the conventional EP buffer. In this study, we utilized 50ug of mRNA per 1x10^7 cells in our experiments. Thank you for joining us on this journey towards a better future! 🌟🧬 #GeneTransfer #EPBufferFree #ProcessDevelopment

What an interesting read! https://lnkd.in/dCUH7Ype The August 30, 2024, Nature Communications article investigates the allosteric activation of the class C GPCR dimer mGlu5. Researchers, led by Mingyu Li and Xiaobing Lan, utilized computational methods and experimental assays to reveal a stepwise activation process involving five metastable states. Agonist binding compacts the ectodomains, promoting TM6-TM6 interface formation, enhancing domain flexibility, and activating crucial micro-switches for signal transduction. A positive allosteric modulator stabilizes active conformations, aiding G protein coordination. The study underscores the importance of dynamic allostery in GPCR activation, providing insights for developing novel therapeutics targeting mGlu receptors.