In partnership with University of Pennsylvania Perelman School of Medicine Vice Provost Dr. Ezekiel Emanuel, MD, PhD, Truveta Research conducted the first-ever study on whether patients taking GLP-1s like semaglutide and tirzepatide showed trends of discontinuing and reinitiating these meds. Now available as a preprint on MedRxiv: https://tr.vet/3YM0q1X #PrePrint #PennMedical #PennMedicalResearch #GLP1Research #WeightLossDrugs #WeightLoss #Semaglutide #Tirzepatide #Wegovy #Ozempic #Mounjaro #Zepbound #HealthData #PrescriptionTrends #AI #Innovation #HealthAI #HealthInnovation #HealthTech #HealthcareData #HealthcareTech #MedicalTechnology #MedicalData #MedTech #PrePrint #MedicalResearch #HealthResearch #PrescriptionTrends
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This paper investigates the total naloxone dose needed to properly reverse respiratory depression associated with fentanyl overdose
Opioids are causing increasing rates of mortality, despite the increasing rate of safe, easily applicable, pharmacological interventions. So what is going on? Omitting epidemiological arguments, maybe we just aren't properly resuscitating on the appropriate time-scales. We can investigate resuscitation protocols using a whole-body physiological model to test a hypothesis that perhaps the amount of Naloxone being administered is insufficient for modern-day synthetic opioids. Given the danger and challenge of opiates in a clinical trial, experimental setting, a computational model lends itself well to answering this question, as a preliminary study. Join me for a talk about how we combine multiple systems models to generate an appropriate patient response, then finally how we use this model to test our hypothesis. #Healthcare #EmergencyMedicine #PhysiologyModels
Dr. Austin Baird
https://systemsmedicine.pulmonary.medicine.ufl.edu
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Opioids are causing increasing rates of mortality, despite the increasing rate of safe, easily applicable, pharmacological interventions. So what is going on? Omitting epidemiological arguments, maybe we just aren't properly resuscitating on the appropriate time-scales. We can investigate resuscitation protocols using a whole-body physiological model to test a hypothesis that perhaps the amount of Naloxone being administered is insufficient for modern-day synthetic opioids. Given the danger and challenge of opiates in a clinical trial, experimental setting, a computational model lends itself well to answering this question, as a preliminary study. Join me for a talk about how we combine multiple systems models to generate an appropriate patient response, then finally how we use this model to test our hypothesis. #Healthcare #EmergencyMedicine #PhysiologyModels
Dr. Austin Baird
https://systemsmedicine.pulmonary.medicine.ufl.edu
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A must read editorial for someone who is interested in clinical trial design, outcomes and regulation of innovative therapies for Inherited Retinal Dystrophies (IRDs). In this piece that is co-authored by clinical scientists, patient experts and IRD specialists, the authors discuss the current challenges and propose potential solutions to foster innovation in the IRDs therapeutic space. 👉 Current challenge include: - several clinical trials not meeting primary endpoints or being withdrawn by investors - issues with clinical trial designs due to small patient populations, appropriate controls and long trial duration - stringent and expensive vector manufacturing regulations - irrelevant endpoint (Best Corrected Visual Acuity) requirements by regulatory agencies 🌟 Proposed solutions: - optimization of trial designs for small populations possibly using adaptive designs - Identification and stratification of appropriate control groups - development of relevant outcome measures specific to the IRD patient population that captures patient experience, daily living activities and ability to adapt to and navigate environments - conduction of natural history studies to identify suitable endpoints for specific IRD types - harmonization of regulatory procedures globally for faster approval process - consideration of conditional approval with close monitoring of post approval data #clinical #research #genetherapy #celltherapy #inherited #retinal #dystrophies #degenerations #retina #innovation #retinainternational #regulation #therapies #drug #discovery #development #erneye #euretina Full text of the article is behind a paywall but can be accessed here: https://lnkd.in/exQn_-km
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Personalized Medicine: Unlocking the Future of Targeted Treatment How Does Personalized Medicine Work? Genetic Testing: A sample of your DNA (from blood or saliva) is analyzed to identify specific genes that influence how your body responds to medications or your susceptibility to certain diseases. Data Analysis: Powerful computers and algorithms compare your genetic information to vast databases to pinpoint treatments most likely to be effective for you. Tailored Treatment: Your doctor receives insights to select medications, adjust dosages, or offer lifestyle recommendations based on your individual needs — maximizing the benefits and reducing the risk of side effects. Where Is Personalized Medicine Making a Difference? Cancer Treatment: Genetic profiling of tumors helps oncologists identify targeted therapies with a higher chance of success, especially in aggressive or advanced cancers. Medication Management: Understanding how your body metabolizes drugs allows doctors to optimize dosages for conditions like depression, pain management, or high blood pressure, preventing unnecessary side effects. Preventative Care: Your genetic blueprint can reveal your risk for developing certain diseases, allowing you and your doctor to make early lifestyle changes or implement preventative screenings, giving you more control over your future health. The Benefits and Considerations of Personalized Medicine Pros: Increased success rates of treatments, decreased side effects, potential for personalized disease prevention plans. Cons: Cost of genetic testing can be high (but decreasing), the evolving science means not all conditions have personalized options yet, and data privacy requires careful consideration. Read the full post at https://lnkd.in/gaWHfAfQ #Healthcare #Medical #Marketing #SEO #DigitalMarketing #HealthcareMarketing #MedicalMarketing #HealthcareSEO #MedicalSEO #PlasticSurgery #CosmeticSurgery #DoctorMarketing #DoctorMarketingMD
Personalized Medicine: Unlocking the Future of Targeted Treatment
medium.com
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It is finally out! Although it feels like ancient history now, we all remember the difficult times during the COVID-19 pandemic. Shortly after the pandemic outbreak started, we initiated a study to investigate the potential of human placental mesenchymal stromal cell-derived small extracellular vesicles (hPMSC-sEVs) as a treatment for critically ill COVID-19 patients. This double-blind, randomized, controlled clinical trial showed promising results, with mortality significantly decreasing in the intervention group compared to the controls. Check out the full paper now available in the Journal of Extracellular Vesicles: https://lnkd.in/dxvMmmMj #COVID19 #Mesenchymalstemcells #ExtracellularVesicles #Clinicaltrail
Human placental mesenchymal stromal cell‐derived small extracellular vesicles as a treatment for severe COVID‐19: A double‐blind randomized controlled clinical trial
isevjournals.onlinelibrary.wiley.com
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Personalized Medicine: Unlocking the Future of Targeted Treatment Imagine leaving behind the frustrating trial-and-error of traditional medicine, where finding the right medication often feels like guesswork. That’s where personalized medicine comes in, a revolutionary approach transforming how we treat diseases by tailoring interventions to your unique genetic profile. How Does Personalized Medicine Work? Genetic Testing: A sample of your DNA (from blood or saliva) is analyzed to identify specific genes that influence how your body responds to medications or your susceptibility to certain diseases. Data Analysis: Powerful computers and algorithms compare your genetic information to vast databases to pinpoint treatments most likely to be effective for you. Tailored Treatment: Your doctor receives insights to select medications, adjust dosages, or offer lifestyle recommendations based on your individual needs — maximizing the benefits and reducing the risk of side effects. Where Is Personalized Medicine Making a Difference? Cancer Treatment: Genetic profiling of tumors helps oncologists identify targeted therapies with a higher chance of success, especially in aggressive or advanced cancers. Medication Management: Understanding how your body metabolizes drugs allows doctors to optimize dosages for conditions like depression, pain management, or high blood pressure, preventing unnecessary side effects. Preventative Care: Your genetic blueprint can reveal your risk for developing certain diseases, allowing you and your doctor to make early lifestyle changes or implement preventative screenings, giving you more control over your future health. The Benefits and Considerations of Personalized Medicine Read the full post at https://lnkd.in/geeqBGVE #Healthcare #Medical #Marketing #SEO #DigitalMarketing #HealthcareMarketing #MedicalMarketing #HealthcareSEO #MedicalSEO #PlasticSurgery #CosmeticSurgery #DoctorMarketing #DoctorMarketingMD
Personalized Medicine: Unlocking the Future of Targeted Treatment
medium.com
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With more than 100,000 views in less than three weeks, Truveta Research's recent peer-reviewed publication comparing weight loss among patients taking semaglutide versus tirzepatide is the most popular study in JAMA Internal Medicine this month. 🙌 See what all the excitement is about: https://tr.vet/46l5lJd #tirzepatide #semaglutide #Mounjaro #Ozempic #WeightLoss #WeightLossMedication #WeightLossDrugs #PrescriptionTrends #GLP1s #HealthData #HealthcareData #HealthcareAI #HealthAI #AI #Innovation #HealthInnovation #HealthcareInnovation #MedicalData #MedicalAI #MedicalInnovation #MedicalTechnology #MedTech #EHRData #ElectronicHealthRecords
Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity
jamanetwork.com
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New paper out! Thanks to Prof Ajeet B Singh MD PhD, David Skvarc and others for the tireless effort required to make this a reality. Given recent developments in the USA, pharmacogenomics is looking increasingly relevent in the field of precision medicine. Personalising tretments for the patient provides benefits in terms of better tolerability, faster response / remission. Additionaly, benefits to society at large, payors, health budgets are possible with these approaches. https://lnkd.in/gpauPZGz
Pharmacogenetics and the Blood–Brain Barrier: A Whirlwind Tour of Potential Clinical Utility
mdpi.com
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🔬 Unlocking the Potential of SNP Detection in Personalized Medicine 🔬 🧬In the intricate tapestry of our genetic code, Single Nucleotide Polymorphisms (SNPs) are like tiny stitches, each representing a subtle variation in our DNA sequence. While individually small, collectively, these SNPs can wield significant influence over our health, disease predisposition, and response to medications. 🩺Personalized medicine, with its focus on tailoring healthcare interventions to the individual characteristics of each patient, has found a potent ally in SNP detection. By identifying these genetic variations, healthcare providers can gain crucial insights into how a person's body may react to certain drugs, which diseases they might be predisposed to, and what preventative measures or treatments would be most effective. 💊Imagine a scenario where a patient with a specific SNP profile is prescribed a medication that's been optimized to precisely target the genetic factors contributing to their condition. This tailored approach not only enhances treatment efficacy but also minimizes the risk of adverse reactions or side effects, leading to better outcomes and improved patient satisfaction. 💡The evolving landscape of SNP detection technologies, from high-throughput sequencing to advanced bioinformatics algorithms, is empowering healthcare professionals with unprecedented precision and accuracy in identifying these genetic variations. As these tools become more accessible and integrated into routine clinical practice, the promise of personalized medicine grows ever closer to reality. #Bioinformatics #PersonalizedMedicine #SNPDetection #HealthcareInnovation
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The report, “Data Harmonization, Standardization, and Collaboration for Diabetic Retinal Disease (DRD) Research: Report From the 2024 Mary Tyler Moore Vision Initiative (MTM Vision) Workshop on Data,” was recently published by TVST, an ARVO Journal. The “Workshop on Data” discussed best practices and specific considerations for building a comprehensive, shareable MTM Vision data lake by standardizing and harmonizing clinical data and ocular omics analyses. Standardization of data collection, common data elements, and data interoperability were emphasized alongside federated learning approaches to promote data sharing and collaboration while maintaining data privacy and security. Integrating molecular data with other multimodal data types was recognized as a promising strategy for leveraging machine learning, and AI approaches to advance therapeutics development and improve treatment outcomes for DRD patients. Partnerships with the National Eye Institute, part of the National Institutes of Health, foundations, and industry were deemed vital for successfully implementing these initiatives. The report was led by Amitha Domalpally, MD, PhD, with contributors including Ward Fickweiler, MD; S. Robert Levine, MD; Kerry E. Goetz; PhD; Brian L. VanderBeek; MD, MPH, MSCE; Aaron Lee, MD; Jeffrey M. Sundstrom, MD, PhD; Dorene Markel, MS, MHSA; Jennifer K. Sun, MD, MPH. Visit https://lnkd.in/eK4qXSBb to read the report. To learn more about our Workshop on “Data Harmonization,” visit the link below: https://lnkd.in/e_ezRbRW #Diabetes #MTMVision #DiabeticRetinopathy #MaryTylerMoore #T1D #Diagnose #HumanEye
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Systems Engineer
2moHello Truveta Team, I recently received a job offer for a Frontend Developer position from someone named Deb Nielsen, who contacted me through Microsoft Teams. I wanted to verify if this offer is genuine. Could you please confirm whether this recruitment is official? Thank you for your assistance.