UAB Department of Medicine’s Post

I am thrilled to share our recent publication entitled "Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay" in Medical Oncology Journal, Q2 Thanks for the whole team https://lnkd.in/dYRBB_zF

The ATR inhibition by Elimusertib enhances the radiosensitivity of MDA-MB-231 triple negative breast cancer in vitro https://bit.ly/4bkBH8i

The first report from the Cancer Programme of the 100,000 Genomes Project, published in Nature Medicine, presents whole-genome sequencing profiles of 13,880 solid tumors spanning 33 cancer types, combined with real-world clinical data, providing insights for precision oncology. Read the paper: https://lnkd.in/eUj3pKgA

For the folk’s interested in targeting MTAP homozygous deletions - this is an excellent dataset to get a reliable patient count / provided the algorithm to call homozygous deletions is fully reliable

Interesting paper with further insights for precision oncology

📚💡❗ARV-471 Phase III study of vepdegestrant, a PROTAC ER degrader, versus fulvestrant in ER+/HER2- advanced breast cancer

A pooled analysis exploring tumor intrinsic subtypes in 3 trials on HER2+ EBC - Elisa Agostinetto JAMA Oncology OncoAlert #BreastCancer #Research #Cancer #HER2E #JAMAOncology #OncoDaily #Oncology #PCR #TumorSubtypes

Molecular docking study of ethyl acetate fraction of Selaginella doederleinii Hieron extract as anti-Warburg effect in breast cancer. https://ow.ly/xRrY50Qx3en

- The Cancer Programme was part of the 100,000 Genomes Project focusing on whole-genome sequencing (WGS) for cancer patients within the UK. - Genomics England and NHS England analyzed WGS data from 13,880 solid tumors covering 33 cancer types. - The analysis integrated genomic data with real-world treatment. - Incidence of somatic mutations varied across cancer types; for instance, glioblastoma multiforme exhibited 94% small variants and 58% copy number aberrations. - Sarcoma showed the highest occurrence of actionable structural variants (13%). - Homologous recombination deficiency was identified in 40% of high-grade serous ovarian cancer cases, with 30% linked to pathogenic germline variants. - Linking WGS and longitudinal clinical data allowed survival analysis, identifying cancer genes impacting prognosis and enhancing understanding of cancer genomics' effect on patient outcomes.

Toxicity of external beam accelerated partial- breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study. https://lnkd.in/eC_ngPwy