UAB Medicine’s Post

Hypertension is a leading medical problem in the US, and except in the very extremes, it is asymptomatic. It is a disease with a specific finding. The medical term is pathognomic finding, which is an elevated blood pressure most often found during a physical examination. In the most common mechanism, a stiffening of the arteries because of atherosclerosis, makes the heart, also at risk for atherosclerosis, now termed coronary artery disease, work harder to generate these higher pressures, putting it at greater risk of failing. There are other hormonal influences as well as interactions with the kidneys that help regulate blood pressure. Hypertension is not only a problem on its own but is associated as a risk factor for cardiovascular and renal disease. https://lnkd.in/eQQYevgQ

New blood pressure procedure is ‘game-changing’ for people with uncontrolled hypertension, say doctors https://lnkd.in/gTG76G6a Explore the Fox News apps that are right for you at https://lnkd.in/gsjXNue.

𝐀𝐩𝐩𝐚𝐫𝐞𝐧𝐭 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐭 𝐡𝐲𝐩𝐞𝐫𝐭𝐞𝐧𝐬𝐢𝐨𝐧. Not a common term that everyone is aware of. Apparent resistant hypertension (aRH) is a type of high blood pressure that does not respond to typical anti-hypertensive medications. This is prevalent in 1 in 10 patients with hypertension. A research conducted by Cedars-Sinai's Smidt Heart Institute, LA, California, suggested that the affected group of patients could better manage their aRH when treated with well-managed aRH were more likely to be treated with a medication called mineralocorticoid receptor antagonist (MRA). Professionals urged patients and doctors to consider alternative therapies and treatment for patients with aRH instead of following a medical regime which prescribes four or more antihypertensive medications. Find out more here: https://lnkd.in/geHA3JTv #treatmentresistant #aRH #apparentResistantHypertension #hypertensionawareness #antihypertensivemedications #highbloodpressure

Tadalafil as a Common ED Treatment Option Lifestyle choices, psychological stress, and underlying health issues including diabetes and cardiovascular disease are contributing to the rise in erectile dysfunction (ED). This issue has increased attention and dependence on pharmaceutical therapies, including tadalafil due to its efficacy and duration. #ED #medical #musclerelaxation #Tadalafil

Happy to share the publication of my recent case report! This case report explores a rare instance of Portal Hypertension and Ascites following Intrauterine Fetal Death, shedding light on the intricate medical complexities involved. I would be honored if you could take a moment to read it, and your support would be greatly appreciated. #medicalresearch #CaseReport #PortalHypertension #Ascites

Wegovy: Good for Weight Loss and Health or Should We Proceed with Caution? 💉 Wegovy is an FDA-approved injectable medication developed specifically for weight loss. As blood sugar levels rise, this medication helps the pancreas produce more insulin. Insulin then aids in moving blood sugar into the body's cells to be used for energy. So, is that a good thing? 👍 Patients are seeing improved liver function and lower rates of stroke, as well as kidney and heart disease. A forthcoming study is expected to show a 20% reduction in heart attacks, strokes, and deaths from cardiovascular causes. This suggests to me that we are likely to see this medication used for much more than just obesity. However, what are the cons of using this weight loss medication? Yes, when patients discontinue the medication, they may regain the weight, but consider this: what happens when a patient stops taking medication such as Semaglutide for cardiovascular disease? Are they then susceptible to a heart attack? What if a patient discontinues any medicine for diabetes, hypertension, or hypoglycaemia? Do people really take Wegovy for extended periods? In my experience, I have seen individuals describe it as life-changing and state that it has had a positive impact on their lives. They claim they wouldn't have been able to lose weight without it, and they enjoy the accompanying health benefits. However, like anything, there is a risk. Do scientists understand precisely the mechanism by which these medications work on the receptors in the brain, and is the slowing of food through the digestive system a concern? I am aware that many doctors prescribe this weight loss medication. What are your thoughts? 🧐

Tadalafil as a Common ED Treatment Option Lifestyle choices, psychological stress, and underlying health issues including diabetes and cardiovascular disease are contributing to the rise in erectile dysfunction (ED). This issue has increased attention and dependence on pharmaceutical therapies, including tadalafil due to its efficacy and duration. #ED #medical #musclerelaxation #Tadalafil

🔬❤️Further cardiovascular benefits of GLP-1 medications ❤️ 🔬 Interesting research about the symptomatic benefits of semaglutide in heart failure patients “In patients with heart failure with preserved ejection fraction and obesity, treatment with semaglutide (2.4 mg) led to larger reductions in symptoms and physical limitations, greater improvements in exercise function, and greater weight loss than placebo” https://lnkd.in/eQCJAKtd Will future NICE guidance change to reflect this and advise on prescribing semaglutide for these patients? As heart failure management is often complex, this decision may ultimately lie with specialist heart failure teams. As a digital provider we constantly review our prescribing to stay in line with national and manufacturer’s guidance in combination with suitability for remote services. #semaglutide #wegovy #ozempic #habitual #novonordisk #glp1 #heartfailure #HFpEF #obesity #weightmanagement #metabolichealth #cardiovascularhealth

The STEP trial evaluated the effects of semaglutide (Ozempic or Wegovy) 2.4 mg weekly in participants with heart failure, obesity (BMI ≥30), and type 2 diabetes. Patients received either semaglutide or placebo for 52 weeks. The primary endpoints were changes in Kansas City Cardiomyopathy Questionnaire (KCCQ) scores and body weight. Semaglutide significantly improved KCCQ scores (+14 vs. +6 with placebo) and led to weight loss (-10% vs. -3% with placebo). Secondary outcomes, such as increased 6-minute walk distance and reduced CRP levels, also favored semaglutide. Serious adverse events occurred less frequently with semaglutide (18%) than with placebo (28%). Dr. Tashko #Semaglutide #Ozempic #Wegovy #CHF #Obesity #Diabetes #STEPtrial

Passionate about revolutionizing hypertension management? Check out my recent letter discussing Zilebesiran's approach to controlling blood pressure with biannual dosing and a favorable safety profile. Let's connect and delve deeper into the future of cardiovascular health together! #Hypertension #Zilebesiran #Cardiovascular