A new UCSF study reveals that administering a second dose of BMZ—a steroid used to protect against severe brain bleeds—at the right time can significantly reduce risks for infants born before 28 weeks. This research provides clinicians with essential insights to refine steroid treatment timing protocols and improve the chances of healthy development for these newborns.
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Professor UCSF, Director of Product Development iPD3, Science and Medicine Committee-March of Dimes Innovation Venture Fund
Thanks UCSF for highlighting our work at iPD3! About 5 years ago, we teamed up with the Bill & Melinda Gates Foundation to identify drugs that could be developed to treat babies born in low- and middle-income country (LMIC) settings following hypoxic-ischemic encephalopathy (HIE), or birth asphyxia. The current standard of care treatment—therapeutic hypothermia—is either difficult to implement or ineffective/contraindicated in these settings. With our pipeline partners Hemmen Sabir at The University of Bonn, Nicola Jayne Robertson at UCL and Anca Pasca at Stanford University, we whittled down over one thousand neurotherapeutic drugs based on their target product profiles to a few dozen that were tested in rodent models and organoids. Here, we report that our most effective candidate, caffeine citrate, met good safety and efficacy endpoints in a highly clinically relevant large animal model. Caffeine administration could thus be an effective approach to help decrease the global burden of cerebral palsy due to HIE. Clinical trials are in planning phases to test it in multiple LMIC settings. www.ipd3.org
Coffee for newborns? Not exactly, but caffeine could play a surprising role in preventing cerebral palsy. UCSF’s Initiative for Pediatric Drug and Device Development (iPD3) found that a few doses given to pregnant animals and their offspring significantly reduced brain damage from birth asphyxia. In the study, researchers found that a single intravenous dose of caffeine (about 10 cups of coffee) for mom, followed by two days of additional doses to offspring significantly reduced inflammation and brain injury in newborns while improving motor activity. https://lnkd.in/gytgXDnw
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🚀Exciting News in Neonatal Research! 🧠🔬 Great study protocol from eleanor molloy and the DEFINE study group, aimed at defining and diagnosing neonatal encephalopathy (NE) with a clear and consistent approach. The DEFINE project employs a real-time Delphi method to create a consensus definition for NE, ensuring better research comparability and improved communication among professionals and with families. ⭐️Purpose: Standardise the terminology and criteria for diagnosing NE, a condition affecting newborns’ neurological function. 🧠👶 ⭐️Method: A global team of experts will conduct a systematic review and a real-time Delphi survey to achieve consensus. 🌐📊 ⭐️Impact: The standardised definition will enhance research quality, improve outcomes, and ensure parents receive accurate and understandable information. 💪📈 #NeonatalEncephalopathy #NeonatalCare #ResearchInnovation #HealthcareImprovement
New study protocol from Aoife Branagan, eleanor molloy and international colleagues. In the DEFiNE study, they aim to establish a consensus definition and diagnostic criteria for neonatal encephalopathy. Children’s Health Ireland (CHI) Trinity College Dublin The Coombe Hospital Health Research Board (HRB) Neonatal Encephalopathy PhD Training Network (NEPTuNE) https://lnkd.in/dUXcziNS
Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study - Pediatric Research
nature.com
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Did you miss our webinar about Vasa Previa: The Role of Ultrasound in Preventing Perinatal Mortality? Watch the recording on our website! Dr. Oyelese discusses the importance of prenatal diagnosis using ultrasound and Color Doppler, which can improve survival rates. You will learn about: 1. The types of vasa previa, as well as the risks and implications 2. Techniques for identifying the condition during routine ultrasound scans 3. Screening protocols and preventative measures that can save lives https://hubs.li/Q02zV9ff0
Vasa Previa: The Role of Ultrasound in Preventing Perinatal Mortality
info.premierus.com
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Professor / CEO and Business Owner / Neonatologist / Inventor / Clinical Trialist / Scientific Advisor / Expert Witness
https://wix.to/oIahXp3 Importance: Compared with early cord clamping (ECC), umbilical cord milking (UCM) reduces delivery room cardiorespiratory support, hypoxic-ischemic encephalopathy, and therapeutic hypothermia in nonvigorous near-term and full-term infants. Objective: To determine the 2-year outcomes of children randomized to UCM or ECC at birth in the Milking in Nonvigorous Infants (MINVI) trial. Design, setting, and participants: The primary trial hypothesized that UCM would reduce admission to the neonatal intensive care unit compared with ECC. Near-term and full-term infants aged 35 to 42 weeks' gestation at birth who were nonvigorous, enrolled in MINVI completed Ages and Stages Questionnaire, 3rd Edition (ASQ-3) and Modified Checklist for Autism in Toddlers, Revised/Follow-Up (M-CHAT-R/F) questionnaires through age 2 years. Results: Among 1730 newborns from the primary trial, long-term outcomes were evaluated in 971 children (81%) who had ASQ-3 scores available at 2 years or died before age 2 years and 927 children (77%) who had M-CHAT-R/F scores or died before age 2 years. Maternal and neonatal characteristics by treatment group were similar, with median birth gestational age of 39 (IQR, 38-40) weeks in both groups; 224 infants (45%) in the UCM group and 201 (43%) in the ECC group were female. The median ASQ-3 total scores were similar (UCM: 255 [IQR, 225-280] vs ECC: 255 [IQR, 230-280]; P = .87), with no significant differences in the ASQ-3 subdomains. Medium- to high-risk M-CHAT-R/F scores were also similar (UCM, 9% [45 of 486] vs ECC, 8% [37 of 441]; P = .86). Conclusions: ASQ-3 scores at age 2 years were not significantly different between the UCM and ECC groups. Combined with previously reported important short-term benefits, this follow-up study suggests UCM is a feasible, no-cost intervention without longer-term neurodevelopmental risks of cord milking in nonvigorous near-term and term newborns. #neonatology #nicu #nicubaby #nicunurse #nicumom #newborn #newbornbaby #nurse #midwifery #midwife #resuscitation#cpr #patient #patientcare #patientsafety #education #medical #medicalstudent #medicalcollege #medicalschool#medicalstudents #medicine #medicaleducation #medico #medicina #medicos #pretermbaby #preterm #oxygen #science #RCT #research #researchpaper #researchers #scientists #latestposts #latestblogs #linkedlnarticles #article #articles #AcademicExcellence #researchproposal #clinicaltrials #ScienceForChange #health #canada #medical #europe #australia #usa #asia #africa #india #ResearchMethods #HealthcareInsights #ClinicalTrialSuccess #PatientEngagement #MedicalResearch #InnovationsInHealthcare #ClinicalTrialManagement #ClinicalTrials #DataManagement #RegulatoryFrameworks #datatransparency #ClinicalDataTransparency #EMA #HealthCanada #medicalwriting #clinicaldatamanagement #clinicaloperations #clinicalresearch #FDA #babies #guidelines #ClinicalTrials #InformedConsent #DeferredConsent #MedicalEthics
Two-Year Outcomes of Umbilical Cord Milking in Nonvigorous Infants: A Secondary Analysis of the MINVI Randomized Clinical Trial
research4babies.org
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Time courses of intrapartum asphyxia: neonatal characteristics and outcomes https://t.co/sdBa1fE3U7 #EurekaMag
Time courses of intrapartum asphyxia: neonatal characteristics and outcomes
eurekamag.com
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New issue of eMultipleSclerosis Review out now! 📢 Pediatric Onset Multiple Sclerosis (POMS) presents unique challenges for young patients. Dr. Haiwen Chen and Dr. Karla Gray-Roncal from Johns Hopkins discuss early diagnosis, high-efficacy treatments, and activity guidelines. Don’t miss this clinical deep dive! #POMS #MSAwareness #MultipleSclerosis #PediatricMS https://buff.ly/3zo14Zc
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Rumination syndrome is classified as both a Functional Gastroduodenal Disorder and a Feeding and Eating Disorder, yet it remains frequently misdiagnosed or overlooked. This oversight can result in prolonged symptoms and delayed treatment for patients. Our recent synthesis of existing research highlights the need for a clearer consensus on the diagnosis, underlying mechanisms, and treatment options for RS. We provide recommendations for clinicians, including: ➡️ Recognizing the diverse clinical presentations of RS ➡️ Utilizing thorough clinical histories for accurate diagnosis ➡️ Implementing targeted diaphragmatic breathing and other interventions By increasing awareness and understanding of RS, we can improve outcomes for patients and ensure they receive the appropriate care. #RuminationSyndrome #FunctionalDisorders #Gastroenterology #PatientCare
Diagnosis and Treatment of Rumination Syndrome: A Critical... : Official journal of the American College of Gastroenterology | ACG
journals.lww.com
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New study finds early detection of miRNAs in maternal blood may offer potential for predicting preeclampsia https://lnkd.in/etmxBzr7
New study finds early detection of miRNAs in maternal blood may offer potential for predicting preeclampsia
medicalxpress.com
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This Norwegian study aimed to estimate the risks of childbirth in a maternal myasthenia gravis cohort based on nationwide data from the Medical Birth Registry of Norway. Jenny L V Lindroos presents in this MEDtalk the study, showing that the risks for elective cesarean section and induced labor were increased, but not for emergency cesarean section. Only a few myasthenia gravis-exposed children had transient neonatal myasthenia gravis, but a large group of the children were referred to a neonatal ward. 🔗Stay updated on EAN: https://lnkd.in/dzTEGiny European Academy of Neurology #EAN24 #Neurology
Women with Myasthenia Gravis are Twice as Likely to Have a Planned Casarean Section
https://bpno.no
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Registered Adult Nurse/Trained Neonatal Nurse/Trained Midwife/Author/NHS England Trained Vaccination Nurse BSc (Hons) Neonatal Nursing
Systematic Review/Meta-Analysis. Abstract from knowledge share library. NIH PubMed. Cochrane Database Systematic Review Dec 2023. [What are the risks and benefits of different positions for spinal taps in infants? A lumbar puncture, commonly known as a spinal tap, is a procedure that involves inserting a needle into the spine. They are often performed in newborns when searching for severe infections including those affecting the brain and spine, to collect cerebrospinal fluid or to insert medications. Because it involves inserting a needle, a spinal tap may cause pain and discomfort.]
Positioning for lumbar puncture in newborn infants - PubMed
pubmed.ncbi.nlm.nih.gov
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