UCSF Pediatrics’ Post

Thanks UCSF for highlighting our work at iPD3! About 5 years ago, we teamed up with the Bill & Melinda Gates Foundation to identify drugs that could be developed to treat babies born in low- and middle-income country (LMIC) settings following hypoxic-ischemic encephalopathy (HIE), or birth asphyxia. The current standard of care treatment—therapeutic hypothermia—is either difficult to implement or ineffective/contraindicated in these settings. With our pipeline partners Hemmen Sabir at The University of Bonn, Nicola Jayne Robertson at UCL and Anca Pasca at Stanford University, we whittled down over one thousand neurotherapeutic drugs based on their target product profiles to a few dozen that were tested in rodent models and organoids. Here, we report that our most effective candidate, caffeine citrate, met good safety and efficacy endpoints in a highly clinically relevant large animal model. Caffeine administration could thus be an effective approach to help decrease the global burden of cerebral palsy due to HIE. Clinical trials are in planning phases to test it in multiple LMIC settings. www.ipd3.org

🚀Exciting News in Neonatal Research! 🧠🔬 Great study protocol from eleanor molloy and the DEFINE study group, aimed at defining and diagnosing neonatal encephalopathy (NE) with a clear and consistent approach. The DEFINE project employs a real-time Delphi method to create a consensus definition for NE, ensuring better research comparability and improved communication among professionals and with families. ⭐️Purpose: Standardise the terminology and criteria for diagnosing NE, a condition affecting newborns’ neurological function. 🧠👶 ⭐️Method: A global team of experts will conduct a systematic review and a real-time Delphi survey to achieve consensus. 🌐📊 ⭐️Impact: The standardised definition will enhance research quality, improve outcomes, and ensure parents receive accurate and understandable information. 💪📈 #NeonatalEncephalopathy #NeonatalCare #ResearchInnovation #HealthcareImprovement

Did you miss our webinar about Vasa Previa: The Role of Ultrasound in Preventing Perinatal Mortality? Watch the recording on our website! Dr. Oyelese discusses the importance of prenatal diagnosis using ultrasound and Color Doppler, which can improve survival rates. You will learn about: 1. The types of vasa previa, as well as the risks and implications 2. Techniques for identifying the condition during routine ultrasound scans 3. Screening protocols and preventative measures that can save lives https://hubs.li/Q02zV9ff0

 https://wix.to/oIahXp3 Importance: Compared with early cord clamping (ECC), umbilical cord milking (UCM) reduces delivery room cardiorespiratory support, hypoxic-ischemic encephalopathy, and therapeutic hypothermia in nonvigorous near-term and full-term infants. Objective: To determine the 2-year outcomes of children randomized to UCM or ECC at birth in the Milking in Nonvigorous Infants (MINVI) trial. Design, setting, and participants: The primary trial hypothesized that UCM would reduce admission to the neonatal intensive care unit compared with ECC. Near-term and full-term infants aged 35 to 42 weeks' gestation at birth who were nonvigorous, enrolled in MINVI completed Ages and Stages Questionnaire, 3rd Edition (ASQ-3) and Modified Checklist for Autism in Toddlers, Revised/Follow-Up (M-CHAT-R/F) questionnaires through age 2 years. Results: Among 1730 newborns from the primary trial, long-term outcomes were evaluated in 971 children (81%) who had ASQ-3 scores available at 2 years or died before age 2 years and 927 children (77%) who had M-CHAT-R/F scores or died before age 2 years. Maternal and neonatal characteristics by treatment group were similar, with median birth gestational age of 39 (IQR, 38-40) weeks in both groups; 224 infants (45%) in the UCM group and 201 (43%) in the ECC group were female. The median ASQ-3 total scores were similar (UCM: 255 [IQR, 225-280] vs ECC: 255 [IQR, 230-280]; P = .87), with no significant differences in the ASQ-3 subdomains. Medium- to high-risk M-CHAT-R/F scores were also similar (UCM, 9% [45 of 486] vs ECC, 8% [37 of 441]; P = .86). Conclusions: ASQ-3 scores at age 2 years were not significantly different between the UCM and ECC groups. Combined with previously reported important short-term benefits, this follow-up study suggests UCM is a feasible, no-cost intervention without longer-term neurodevelopmental risks of cord milking in nonvigorous near-term and term newborns. #neonatology #nicu #nicubaby #nicunurse #nicumom #newborn #newbornbaby #nurse #midwifery #midwife #resuscitation#cpr #patient #patientcare #patientsafety #education #medical #medicalstudent #medicalcollege #medicalschool#medicalstudents #medicine #medicaleducation #medico #medicina #medicos #pretermbaby #preterm #oxygen #science #RCT #research #researchpaper #researchers #scientists #latestposts #latestblogs #linkedlnarticles #article #articles #AcademicExcellence #researchproposal #clinicaltrials #ScienceForChange #health #canada #medical #europe #australia #usa #asia #africa #india  #ResearchMethods #HealthcareInsights #ClinicalTrialSuccess #PatientEngagement #MedicalResearch #InnovationsInHealthcare #ClinicalTrialManagement #ClinicalTrials #DataManagement #RegulatoryFrameworks #datatransparency #ClinicalDataTransparency #EMA #HealthCanada #medicalwriting #clinicaldatamanagement #clinicaloperations #clinicalresearch #FDA #babies #guidelines #ClinicalTrials #InformedConsent #DeferredConsent #MedicalEthics

Time courses of intrapartum asphyxia: neonatal characteristics and outcomes https://t.co/sdBa1fE3U7 #EurekaMag

New issue of eMultipleSclerosis Review out now! 📢 Pediatric Onset Multiple Sclerosis (POMS) presents unique challenges for young patients. Dr. Haiwen Chen and Dr. Karla Gray-Roncal from Johns Hopkins discuss early diagnosis, high-efficacy treatments, and activity guidelines. Don’t miss this clinical deep dive! #POMS #MSAwareness #MultipleSclerosis #PediatricMS https://buff.ly/3zo14Zc

Rumination syndrome is classified as both a Functional Gastroduodenal Disorder and a Feeding and Eating Disorder, yet it remains frequently misdiagnosed or overlooked. This oversight can result in prolonged symptoms and delayed treatment for patients. Our recent synthesis of existing research highlights the need for a clearer consensus on the diagnosis, underlying mechanisms, and treatment options for RS. We provide recommendations for clinicians, including: ➡️ Recognizing the diverse clinical presentations of RS ➡️ Utilizing thorough clinical histories for accurate diagnosis ➡️ Implementing targeted diaphragmatic breathing and other interventions By increasing awareness and understanding of RS, we can improve outcomes for patients and ensure they receive the appropriate care. #RuminationSyndrome #FunctionalDisorders #Gastroenterology #PatientCare

New study finds early detection of miRNAs in maternal blood may offer potential for predicting preeclampsia https://lnkd.in/etmxBzr7

This Norwegian study aimed to estimate the risks of childbirth in a maternal myasthenia gravis cohort based on nationwide data from the Medical Birth Registry of Norway. Jenny L V Lindroos presents in this MEDtalk the study, showing that the risks for elective cesarean section and induced labor were increased, but not for emergency cesarean section. Only a few myasthenia gravis-exposed children had transient neonatal myasthenia gravis, but a large group of the children were referred to a neonatal ward. 🔗Stay updated on EAN: https://lnkd.in/dzTEGiny European Academy of Neurology #EAN24 #Neurology

Systematic Review/Meta-Analysis. Abstract from knowledge share library. NIH PubMed. Cochrane Database Systematic Review Dec 2023. [What are the risks and benefits of different positions for spinal taps in infants? A lumbar puncture, commonly known as a spinal tap, is a procedure that involves inserting a needle into the spine. They are often performed in newborns when searching for severe infections including those affecting the brain and spine, to collect cerebrospinal fluid or to insert medications. Because it involves inserting a needle, a spinal tap may cause pain and discomfort.]