Understanding Animal Research’s Post

#Diabetic #wounds, often resistant to conventional treatments, pose serious health risks to millions of people worldwide. #Immune cells known as #macrophages, which are supposed to help, end up causing #inflammation instead, making it harder for the wound to heal properly and quickly. Now, researchers from the Icahn School of Medicine at Mount Sinai and The Ohio State University have designed a #regenerative medicine therapy to speed up diabetic wound repair. Using #lipid #nanoparticles loaded with #RNA encoding a signaling protein known as a #cytokine, the therapy targeted dysfunctional macrophages while simultaneously reducing inflammation in diabetic wounds. "In preclinical models, we basically showed the therapy's ability to reprogram pro-inflammatory macrophages into reparative ones, leading to improved wound healing outcomes," said Yizhou Dong, one of the scientists involved in this study. https://lnkd.in/gqVgtuP6 (Work funded by The National Institutes of Health)

A new study at Duke University Health System leveraged #XenonMRI to compare bilateral lung transplant patients with known chronic lung allograft dysfunction (CLAD) to healthy volunteers. Sensitive and noninvasive methods of screening for CLAD are essential, given the 60% five-year survival rate for lung transplant patients. This research highlights an investigational use of Xenon MRI where the ventilated airspaces, the alveolar membrane tissue, and the red blood cells (RBC) within pulmonary capillaries were studied to evaluate both lung ventilation and gas-exchange. The authors conclude that, patients with CLAD exhibited significant ventilation defects that correlated with FEV1 decline from max post-transplant value, which along with RBC transfer defects and other Xenon MRI gas-exchange biomarker abnormalities, could provide a promising means of early detection of physiological changes in patients with CLAD. Congratulations to Austin Simmons, David Mummy, Azfar Ali Hakim, and the entire lung transplant team at Duke on the publication of their recent study! Read the full article here: https://lnkd.in/ekqrvW-P #PulmonaryMedicine #LungMRI #Innovation #DrugDeviceCombination #PulmonaryImaging #CLAD

Thrilled to share more groundbreaking Polarean #XenonMRI work published by the Duke University Health System team, including our CSO, Dr. Bastiaan Driehuys, alongside physician collaborators Drs. Scott Palmer and Azfar Ali Hakim. Duke is home to one of the largest and most advanced #lungtransplant programs in the U.S. 🫁 Lung transplants are on the rise, driven by advancements like an expanded donor pool and innovative policies such as the 2023 "Continuous Distribution" Framework developed by the United Network for Organ Sharing (UNOS), which removes geographic barriers and prioritizes patients based on need. These developments, along with cutting-edge technologies like ex vivo lung preservation systems from a couple of leading Massachusetts #MedTech companies (TransMedics, Inc. and Paragonix Technologies, Inc.), are improving outcomes and increasing access to life-saving transplants. A big thank you to our collaborators for their dedication to advancing lung health. More to come as we continue to work together to revolutionize pulmonary medicine. #RevolutionizingPulmonaryMedicine #MedicalImaging #LungImaging #MRI

Save the date! July 17, 2024: Front Row Lecture with Michael Bollong   Regenerative medicine involves harnessing the body’s capacity to repair tissues and organs. Join us on Wednesday, July 17, as Associate Professor Michael Bollong shares how he is identifying and targeting the pathways controlling regeneration, and developing novel medicines to intervene in the processes that cause a spectrum of human diseases, including heart disease, inflammatory disease and fibrosis. #medicine #heartdisease #fibrosis Register here ⬇

Nizamoglu and Koloko Ngassie et al. discovered that collagen type XIV is found in lower amounts in the lung tissues of patients with idiopathic pulmonary fibrosis (IPF), a serious lung condition. Using advanced image analysis on lung tissue obtained from non-diseased control and patients with IPF, they show that this protein, which is important for organizing other proteins in the lung, is not as abundant in IPF patients compared to healthy individuals. This lack of collagen type XIV could be influencing the structure of the lung tissue, potentially contributing to the worsening of the disease. Read Matt's full article at Nature Scientific Reports: https://lnkd.in/gZPq5QsE Matt Nizamoglu, PhD #COLXIV

Stool transplant could improve motor symptoms in Parkinson’s disease A small clinical trial in Belgium published in The Lancet found that stool transplants could potentially improve motor symptoms in early-stage Parkinson’s disease patients. Participants who received a faecal transplant from a healthy donor showed an improvement in their motor score by 5.8 points after 12 months, compared to a 2.7-point improvement in those who received a placebo transplant. The study, published in eClinicalMedicine, suggests faecal transplants might affect the gut microbiome in a way that positively impacts motor symptoms of Parkinson's disease. This research opens up new avenues for exploring how the gut microbiome influences neurodegenerative conditions like Parkinson's, though more research is needed to fully understand the mechanism and long-term effects of such treatments. Link to Study: https://lnkd.in/g2CYGUt8 #parkinsons #microbiome #guthealth #metagenomics #gutbrainaxis

Explore personalized treatment options targeting the interactions between T and B cells for autoimmune diseases like rheumatoid arthritis, as indicated by a recent University of Surrey study in Clinical and Translational Medicine. By understanding the complex relationship between these cells, tailored therapies can be developed to alleviate symptoms and improve quality of life. Stay informed on advancements in T and B cell research to empower informed decisions about managing autoimmune conditions effectively. #AutoimmuneDisease #ImmunologyResearch #PersonalizedTreatment #CellInteractions #ChronicIllness BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X. Read more about this post here: https://lnkd.in/eqj_zQ4N

A nested case-control study in China showed "Biomarkers evolved in a temporal sequence over 20 years in people who developed #Alzheimers disease." "Over a median follow-up of 19.9 years, cerebrospinal fluid (CSF) and imaging biomarkers changed in a specific order, with differences seen in people who subsequently were diagnosed with sporadic #AlzheimersDisease and people who remained cognitively normal." Learn More in the New England Journal of Medicine https://lnkd.in/ewEWmWXH Biomarker Changes during 20 Years Preceding Alzheimer’s Disease List of authors. - Jianping Jia, Yuye Ning, Meilin Chen, Furu Liang, Zhengluan Liao, Shan Wang, et al. Xuanwu Hospital Capital Medical University ACCOMPANYING EDITORIAL: Alzheimer’s Disease Biomarkers — Timing Is Everything - Richard Mayeux, M.D. Columbia University https://lnkd.in/ePSsTEJ2

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic https://lnkd.in/giavG4wb by Ai Huey Tan, Shen Yang Lim and Anthony Lang Further readings: 1. Parkinson's disease and gut microbiota: from clinical to mechanistic and therapeutic studies (2023) https://lnkd.in/gGwgTcK3 2. Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson's Disease from Mice to Human (2023) https://lnkd.in/gTdk3PaT 3. Microbiome and Metabolome Insights into the Role of the Gastrointestinal-Brain Axis in Parkinson's and Alzheimer's Disease: Unveiling Potential Therapeutic Targets (2022) https://lnkd.in/gANDNZT5 4. Gut Vibes in Parkinson's Disease: The Microbiota‐Gut‐Brain Axis (2019) https://lnkd.in/gBqX-TWe

We are highly pleased to share our latest research on “RNA in cardiovascular disease: A new frontier of personalized medicine” Published with Progress in Cardiovascular Disease, Impact factor 9.1. This review explores the newest developments in medical studies, treatment plans, and results related to RNA therapies for heart disease. Furthermore, it discusses the exciting possibilities and difficulties in this innovative area of research. Find the link to the full publication below ⬇️ https://lnkd.in/eXEQygPq Congratulations to the team🎉🎊 Toufik Abdul-Rahman, MD Ileana Lizano-Jubert Zarah Sofia Blake Bliss Neil Garg Emily M. Meale Poulami Roy Salvatore Antonio Crinò Deepak Bethineedi Goshen Miteu Wireko Andrew Awuah, MD Abdul Qadeer, MD Alexandra Condurat Andia Diana Tanasa Nikolaos Pyrpyris Kateryna Sikora Viktoriia Horbas Aayushi Sood Rahul Gupta Carl J. Lavie #rna #personalizedmedicine #procisionmedicine #researchstudy #researchpublication #research #researchpaper #cardiovasculardisease #cardiovascularhealth #cardiovascularcare