University of Colorado Cancer Center’s Post

Through a new collaboration, stem cell researcher Dieter Egli, PhD and cancer researcher Juan Manuel Schvartzman, MD, PhD are investigating the stressors that embryos experience during the very early period of replication and how they respond to those stressors. Their research may have implications for health challenges ranging from in vitro fertilization to cancer, since cancer cells resemble early embryonic cells, they note. “We really don’t know very much about how this window of genomic instability in early development affects our health as adults, and that’s very important to understand. It could very well help us understand health and disease in many different areas,” says Dr. Egli. The Columbia University Irving Medical Center collaborators recently received a substantial grant from the W. M. Keck Foundation for this work. Read more here - https://bit.ly/4glSoDy #StemCellResearch #CancerResearch #EmbryonicDevelopment #GenomicInstability #HealthInnovation #MedicalBreakthroughs #KeckFoundation #IVFResearch #EarlyDevelopment #CancerAndHealth #ResearchCollab #columbiamed

An impressive fifty-five Peter MacCallum Cancer Centre researchers have been named in the top two per cent of most-cited scientists in the world based on a recently updated study published by Stanford University.   The top two per cent includes the top 100,000 most cited scientists as determined by a composite citation score, or “c-score”, focusing on the impact of citations rather than productivity (number of publications). The large number of Peter Mac researchers on the list illustrates our top-tier research status and positions our researchers in the highest impact rank in their research community. https://lnkd.in/gHVUscFQ

🖐️ Are you interested in learning more about chromosome biology research at NCI? Investigators at the NCI Center for Cancer Research pioneered the study of chromatin, demonstrating its functional importance and laying the groundwork for understanding its role in cancer and other diseases. Learn more about the important research being done in this area, and about opportunities available to those interested in pursuing a career in chromosome biology research: https://go.nih.gov/SkQZXV1 #NationalCancerResearchMonth

Journal of Cancer Therapy and Research The Cancer Biology basic and translational investigators with expertise in mechanisms of cancer development, cell signaling, DNA repair, aging, stem cells, genomics, and tumor heterogeneity. Acess our journal here: https://lnkd.in/dJe3Huxs Submit your work online here: https://lnkd.in/gakUevWi For anymore queries whatsapp at: +1 (438) 699-5365 #cancerbiology #cancerresearch #cancertreatment #cellsignaling #cancerstemcell #celltherapy #submissionopen #submitmanuscript #openaccess #postdoc #researcher

📢 New Blog Post! You know the hallmarks of #cancer, but do you know the order in which they occur? Read this article by PhD student 𝑳𝒖𝒄𝒊𝒆 𝑮𝒐𝒖𝒓𝒎𝒆𝒕 to learn more https://bit.ly/3RE0egP Cancer Research UK (CRUK) UCL

If you want to know more about my research, please read this blog! 

“Hartwig, by virtue of being a national initiative, has comprehensively profiled metastatic tumor samples using WGS, and more recently also includes transcriptomics. It enabled analyses that were not possible without the number of patient samples a national initiative could provide”: Lodewyk Wessels, Group leader Computational Cancer Biology The Netherlands Cancer Institute. Daniel Vis, Postdoctoral Research Fellow, Soufiane Mourragui, Computational Biologist Hubrecht Institute, Developmental Biology and Stem Cell Research, Jinhyuk Bhin  Would you like to use this data, too? https://lnkd.in/excwE-kp  The data is anonymized and made available free of charge to cancer research institutes and hospitals. It is used by research groups all over the world. Hartwig Medical Foundation is a not-for-profit organization that promotes scientific research in the fight against and treatment of cancer and other diseases, in the broadest sense and provided it is in the public interest.   #cancerresearch #cancergenomics #bioinformatics 

‘Cancer is a tidal wave coming.’ Over 500,000 people in the United States and over 8 million people worldwide are dying every year from cancer. As people live longer, the incidence of cancer is rising worldwide and the disease is expected to strike over 20 million people annually by 2030. I recently completed the Cancer Biology specialization offered by Johns Hopkins University. The program consists of three courses: -Introduction to the Biology of Cancer. -Understanding Cancer Metastasis. -Understanding Prostate Cancer. During this specialization, I delved into: 🧬 The genetics of cancer 🔬 Cancer Metabolism 🏷️ The ten cellular hallmarks 🦠 Cancer Metastasis 💉 Treatment methods for different cancer types 🩺 Cancer diagnosis, staging, grading, and screening 👨⚕️ Prostate cancer in detail I'm looking forward to applying the knowledge gained during this program and working on projects at the intersection of cancer biology, machine learning, and bioinformatics in the upcoming months. Machine learning is revolutionizing cancer diagnosis, prognosis, treatment, and drug discovery by enabling more accurate, personalized, and efficient approaches. #CancerBiology #CancerResearch #MachineLearning #Bioinformatics #GenAI #MedicalImaging

Introduction to the Biology of Cancer - Johns Hopkins University During this course, I gained a comprehensive understanding of cancer biology, including the following key topics: Types of Cancer 1.Carcinomas 2.Sarcomas 3.Leukemias 4.Lymphomas I explored common cancers like breast, prostate, and lung cancer, learning their unique features and behavior. Hallmarks of Cancer 1.Replication immortality 2.Genome instability 3.Evasion of growth suppression signals 4.Resistance to cell death 5.Sustained proliferation 6.Altered metabolism 7.Avoiding immune destruction 8.Induction of angiogenesis 9.Antiapoptotic and Proapoptotic Pathways Understanding the mechanisms of cell death resistance and the role these pathways play in cancer survival. Cancer Staging I delved into the cancer staging system, such as T3N1M1b, signifying a large invasive tumor spreading to lymph nodes and bones. Steps in Cancer Metastasis 1.Primary tumor growth 2.Angiogenesis 3.Epithelial-to-mesenchymal transition 4.Invasion 5.Intravasation 6.Survival in circulation 7.Extravasation 8.Dormancy I also studied the "Seed and Soil Hypothesis", which explains the spread of cancer to specific organs. Imaging Techniques Explored various techniques such as X-rays, Ultrasounds, MRI, and Nuclear Medicine for cancer diagnosis and monitoring. Main Treatment Options 1.Surgery 2.Nuclear Radiation (Radium 223) 3.Hormonal Therapy (Tamoxifen, Anastrozole, Leuprolide, Goserelin, Flutamide, Spironolactone) 4.Chemotherapy (5-Fluorouracil, Capecitabine, Cisplatin, Carboplatin, Cyclophosphamide, Etoposides, Vincristine, Vinblastine, Docetaxel, Paclitaxel) 5.Targeted Therapy (Bevacizumab, Afatinib, Tarceva, Trastuzumab, Everolimus, Ibrance) 6.Immunotherapy (Nivolumab, Pembrolizumab, Ipilimumab) Clinical Trials Phases Phase 1 – Dose finding for toxicity in cancer patients Phase 2 – Finding efficacy by targeting specific cancers Phase 3 – Comparing the drug to the standard of care #CancerBiology #Oncology #Metastasis #CancerHallmarks #CancerTreatment #Immunotherapy #Chemotherapy #TargetedTherapy #HormonalTherapy #ClinicalTrials #CancerResearch #JohnsHopkinsUniversity

The precise causes of brain cancer in children are still unknown. Dr Vinoj George and his research group at Keele University are working to change this. They're looking at the role of genetics in ependymoma - the second most common brain tumour in children. Other cancer research projects typically involve giving cancer to live animals. However, human cell models like the one used by the Keele researchers can provide a more human-relevant research output. Using an innovative stem cell model, the scientists replicated this type of cancer in a dish. They will use optogenetic CRISPR technology to switch certain genes 'on' and 'off' and assess their impact on tumour behaviour. This technology has never before been harnessed to genetically engineer a known cancer mutation in brain cancer research. 🔎 💬 “The crosstalk between neurons and ependymoma cells invading neural circuitry is challenging to replicate with animals,” says Dr George. “Our approach offers an opportunity to discover new treatment options for childhood ependymoma, without resorting to animal models.” Learn more about this exciting research project: https://lnkd.in/eKBnjVJP #ChildhoodCancerAwarenessMonth #Ependymoma #CancerResearch