Pyruvate kinase (PK) deficiency is a red blood cell enzyme disorder that causes chronic hemolysis. The PK activator mitapivat was approved in 2022 for people with anemia from PK deficiency based on improvements in hemoglobin over 24 weeks. Now, with follow-up of 96 weeks, mitapivat has demonstrated reductions in iron overload. This supports using mitapivat for PK deficiency. Although not approved in individuals <18 years, we use it in younger patients after discussion of risks and benefits. Discover What's New in #hematology: https://ow.ly/SrzE50SvxL1 #ClinicalUpdates #meded
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Maintaining hematocrit below 45% is easier said than done for some living with polycythemia vera (PV). Learn about how we aim to address this rare chronic blood disorder with a hepcidin mimetic discovered through our peptide technology platform: https://lnkd.in/ezeut_bf #hematology | #bloodcancer
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Controlling hematocrit levels while also avoiding iron deficiency is a challenge for many living with polycythemia vera (PV). Learn more about PV and our work to address unmet needs for patients: https://lnkd.in/erKMV5Wx #hematology | #bloodcancer | #mpn
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Erba Transasia is set to revolutionize hematology analysis with our upcoming diagnostic technology! Our cutting-edge solution is designed to meet the intricate needs of your laboratory, enabling effortless detection of hematological disorders. Equipped with 7 reagent systems and capable of processing up to 100 samples per hour, this hematology innovation is poised to revolutionize your laboratory workflow. Share this post using the hashtag, #HighEndHematology or comment below with the hashtag, #HighEndHematology to express your anticipation for the upcoming launch. Watch this space to know more! #IAmTransasia #WeAreErba #hematology #clinicalanalysis #IVD #pathology #HighEndHematology
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Erba Transasia is set to revolutionize hematology analysis with our upcoming diagnostic technology! Our cutting-edge solution is designed to meet the intricate needs of your laboratory, enabling effortless detection of hematological disorders. Equipped with 7 reagent systems and capable of processing up to 100 samples per hour, this hematology innovation is poised to revolutionize your laboratory workflow. Share this post using the hashtag, #HighEndHematology or comment below with the hashtag, #HighEndHematology to express your anticipation for the upcoming launch. Watch this space to know more! #IAmTransasia #WeAreErba #hematology #clinicalanalysis #IVD #pathology #HighEndHematology
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Diff Quick III stain for hematology provides a quick 15 second slide dip procedure. Check out the new lower pricing ↘ : https://lnkd.in/gZFnU5Gn #Hematology #LabEfficiency #FastStaining #ClinicalLab #Pathology #LaboratoryScience #Diagnostics
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𝐂𝐑𝐈𝐒𝐏𝐑-𝐌𝐨𝐝𝐢𝐟𝐢𝐞𝐝 𝐌𝐞𝐬𝐞𝐧𝐜𝐡𝐲𝐦𝐚𝐥 𝐒𝐭𝐫𝐨𝐦𝐚𝐥 𝐂𝐞𝐥𝐥𝐬 𝐒𝐡𝐨𝐰 𝐓𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜 𝐏𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐢𝐧 𝐎𝐬𝐭𝐞𝐨𝐚𝐫𝐭𝐡𝐫𝐢𝐭𝐢𝐬 In an article published in Molecular Therapy, researchers at Rush University Medical Center in Chicago report that simultaneous Sox9 activation and RelA inhibition using a catalytically-dead Cas9 resulted in engineered mesenchymal stromal cells with enhanced cartilage-forming potential and downregulated inflammatory responses. Read more 👇🏻 https://lnkd.in/emZxa_HE #crisprmedicinenews #crisprmedicine #crispr #geneediting #osteoarthritis
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Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) are both derived from the patient's blood but differ in preparation and effects. PRP is made by centrifuging blood with anticoagulants, creating a plasma rich in platelets and growth factors for quick release and short-term benefits. PRF, on the other hand, is made without anticoagulants and centrifuged at a slower speed, forming a fibrin matrix that traps more platelets, growth factors, and stem cells. This matrix releases growth factors slowly, promoting longer-term tissue regeneration and healing. PRF’s fibrin matrix also supports cell migration and adhesion, enhancing the healing process compared to PRP. #MadeInMiami . . . #Aesthetics #Fillers #Juvederm #Restylane #LipFiller #Injectables #Filler #Lips #Botox #MiamiFillers #MiamiLips #MiamiBotox #MiamiBeauty #MiamiAesthetics #Prf #Prp #MiamiPrf #Dysport #Injections #Botoxresults #Morpheus8 #Morpheus8Miami #Morpheus8benefits #Brickell #MiamiBrickell #weightlosssolutions #weightloss #sculptra #sculptramiami
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Facial infiltrating #lipomatosis (FIL) is a rare condition with no current treatment, in which #adipocytes invade neighboring tissues and cause swelling of the face. With help from a LUNA-FL Dual #Fluorescence #CellCounter, researchers conducted #singlecell #transcriptome #sequencing on facial adipose tissue from FIL patients to identify FKBP5 as a potential therapeutic target. https://ow.ly/GEH450SJa4Z #adipogenesis #lipocyte #scRNAseq #cellcount #cellviability #cellcounting
Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis | Stem Cell Research & Therapy
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Acromegaly is a rare debilitating endocrine disease characterised by hypersecretion of growth hormone (GH). It is generally accepted that the clinical manifestations of acromegaly are mediated through elevations in serum IGF-I concentrations. Somavert is indicated for the treatment of patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalize IGF-I concentrations or was not tolerated. Pegvisomant, the active substance in Somavert, is a 40-50 kDa molecular variant of the human growth hormone (hGH) consisting of recombinant protein component and polyethylene glycol (PEG). The protein molecule (B2036) is modified by covalent addition of polyethylene glycol (PEG) molecules resulting in a pegylated protein (B2036-PEG) with 4 and 5 PEG groups per B2036-PEG molecule. https://lnkd.in/eANMFJvW #Pegvisomant #peg
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Medical Laboratory Technologist | MD'23|Hematology | Biochemistry | Microbiology | Memberships | ASM | ASCP | ASLM | BSI | Ex Nishtarian |
Diagnostic Hematology: 1:Physiologic Features of Body 2:Overview of Blood 3:Red Blood Cells & White Blood Cells and their Disorders 4:Platelets & Hemorrhagic Disorders 5:Hematology Tests. #hematology #diagnostic #disorders #laboratorytesting #professionals #blood
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3moStandardofcare.com/pyruvate-kinase-deficiency a review Standardofcare.com/subscribe-to-standard-of-care