Vanaraj Rabari’s Post

Whole brain imaging of neuroinflammation (blue) and vasculature (red and yellow) in response to stroke. https://lnkd.in/euzPbd9v   This awesome staining was done by Lea Lydolph and is part of an excellent collaboration with Kate Lykke Lambertsen.   #cns #neuroscience #brain #stroke #neurodegeneration #cro #preclinical #preclinicalresearch Gubra #neuroinflammation #spatialbiology  

🔊 Latest news!   🧠 Slc4a4 restores normal brain function after ischemic stroke Researchers from numerous institutions including Baylor College of Medicine and Texas Children's Hospital have elucidated how Slc4a4 governs astrocyte-endothelial cell interaction in blood-brain barrier maintenance and repair. Click the link in the comments to read more! 👇 #neuroscience #stroke #therapeutics

Big thanks to Bernat De las Heras de Miguel for bringing this paper together, helping us understand the literature on how we can measure neuroplastic changes in response to cardiovascular exercise after stroke

The human brain is an organ of prediction! We use our knowledge and experiences to predict outcomes and guide our decisions. But what is the neurobiological basis of this process? An intriguing article, published this month by Fried and colleagues, revealed that ‘human hippocampal and entorhinal neurons gradually modify their activity to encode the temporal structure of a complex image presentation sequence.’ Electrophysiological recordings from single neurons via depth electrodes, stereotactically implanted in patients with intractable epilepsy, demonstrated that specific neurons, in the brain regions involved in learning and memory, were active when images were presented to participants in a random sequence order. This neuronal activity signature persisted even after the images were no longer shown to participants, suggesting a ‘neuronal replay’ of the experience in their minds. Moreover, these neuronal activity signatures hinted at the brain’s ability to predict the next image! Link to the Nature paper: https://lnkd.in/eEWqxwtK #MedicalResearch #Neuroscience #SurgicalInnovation #Neurosurgery #MedicalTechnology #BrainHealth #PatientCare #ClinicalExcellence #HealthcareInnovation #HealthcareLeadership

In this recent article, authors provide a critical analysis on the current evidence supporting use of neurophysiological, neuroimaging, and blood biomarkers to assess the neuroplastic response to cardiovascular exercise after stroke. https://lnkd.in/g5GhS3F3 #neurorehabilitation #rehabilitation #neuroscience #neuroimaging #biomarkers #stroke #exercise #research #science

🥇Read the Top Cited Papers in 2023! 👉fMRI-Based Alzheimer’s Disease Detection Using the SAS Method with Multi-Layer Perceptron Network 👉 https://lnkd.in/e8HSCpkB MDPI Scilit #neuroscience #brain #fMRI #AD #AlzheimerDisease #MRI #FunctionalMagneticResonanceImaging #MagneticResonanceImaging

Whole brain imaging with single cell resolution. Find out how quantitative Light Sheet Fluorescence Microscopy (LSFM) can be used to study neurodegenerative diseases such as Parkinson's and Alzheimer's: https://lnkd.in/euzPbd9v Gubra #preclinicalresearch #preclinical #neuroscience #neurodegenerativediseases #neurodegeneration #cns #parkinsonsdisease #alzheimersdisease #alzheimers #parkinsonsresearch #alzheimersresearch

🧠 Dive deep into #neuropathology evaluations and toxicity studies in an upcoming webinar with StageBio! In this session, Lisa Mangus DVM, PhD, DACVP, will guide you through the essential techniques needed to visualize morphologic changes in both the central and peripheral nervous systems. 🔬 From fixation and processing to staining, attendees will gain valuable insights into each step of the process. 📊 Discover best practices for tissue collection and preparation, as well as insights on staining techniques and their benefits. Plan ahead for using quantitative techniques in your studies and explore optimal sampling and evaluation strategies for both GLP and non-GLP neuropathology studies. Additionally, learn how to plan and prepare for quantitative neuropathologic techniques such as stereology and nerve histomorphometry, ensuring accurate and reliable results in your studies. ➡️ REGISTER HERE: https://buff.ly/3ULRJ4f #ClinicalResearch #NeurodegenerativeDisease #Pathology #CNS #Neuroscience #CNSTrials #Neurology #BioanalyticalTesting #CNSDrugDevelopment #PreClinical #ToxicologySafety

A new and short format for a quick overview on how to use our cells in a specific assay, introducing iCell Lab Notes! We're kicking things off with how to obtain robust IL-6 cytokine release from our human iCell Microglia!

Explore Alzheimer's disease research with our application note. See how Volumescope SEM and Amira Software reveal changes in neuron morphology due to MCI inhibition. Read more about the efficient analysis and processing capabilities. #AlzheimersResearch #Neuroscience