Vazyme Biotech’s Post

In our new #Big4BioPodcast episode, we spoke with Tim O'Bryan, director of discovery partnerships and commercial integration at Charles River Laboratories, and Dr. Karl Bertram, co-founder and managing director for ATEM Structural Discovery. We explore ATEM’s cryo electron microscopy technology, or Cryo-EM, its incorporation of machine learning, and how it fits in with Charles Rivers’ broader #drugdiscovery offerings. Cryo-EM enables high-resolution screening for small molecules and biological ligands, particularly for targets that are challenging to crystallize. 🎙 Listen to the episode here: https://lnkd.in/eMmTgX8s #biotech #biotechnology #machinelearning

💡 Introducing: Our novel nicrofluidic chip family for the cultivation of non-adherent cell types under flow The first day of EUROoCS Annual Meeting has begun, and we are excited to meet all of you and discuss how #microfluidics can advance your OoC experiments! Be sure to visit our poster presentation on Thursday, July 4th, where we showcase two of our innovation for microfluidic cell culture applications. Our second poster (#369), presented by our cell culture scientist Dr. Elena Müller, highlights our novel chip family for the cultivation of non-adherent cells. When? Thursday, July 4th, from 12:30 - 14:00 PM Where? Poster 269 Our system allows: 📍 Easy seeding of cells into cultivation chambers via pipetting 📍 Retention of non-adherent cells and cell constructs with negligible cell loss during fluidic flow. 📍 Two operation modes: passive and active fluid handling 📍 User-friendly operation and read-out thanks to matching handling frame As proof-of-concept, we established a fluorescence cell staining protocol for suspension cells using these chip types. Attending EUROoCS and interested in this application? Don't miss Elena Müller's poster presentation to learn more about this innovative approach to non-adherent cell culture technology! #Euroocs #OrganOnAChip #Microfluidics #CellCulture #SuspensionCells #FluorescenceStaining

🌟 Exciting Breakthrough in Nucleic Acid Testing! 🧬✨ 🔬 Sharing an amazing development in the world of nucleic acid amplification tests 🌐. We know how crucial Fluorescence Resonance Energy Transfer (FRET) reporters are in indicating the presence of nucleic acid targets. 🎯 However, the dual labeling and purification process during manufacturing makes them a bit on the pricey side. 💸 But guess what? 🤔 We've got a game-changer! 🚀 Introducing a low-cost silver nanocluster reporter that takes a different approach - no more FRET, folks! 🙅♂️ Instead, it relies on a cool cluster transformation process that results in a vibrant fluorescence color change after nuclease digestion. 🌈✨ The magic happens with a 90 nm red shift in emission upon reporter cleavage - something your typical FRET reporter can't achieve. 🌟 Our Electrospray Ionization–Mass Spectrometry results hint at the stoichiometric change in silver nanoclusters, going from Ag13 to Ag10 during digestion, causing that stunning color transformation. 🔄🔍 What does this mean for you? 🤷♀️ Well, our DNA-templated silver nanocluster probes are not only versatile reporters for detecting nuclease activities but also offer valuable insights into the fascinating world of interactions between nucleases and metallo-DNA nanomaterials. 🤯🧬 🌐💪 #innovation #molecular #diagnostics #nanotechnology #nucleicacid #testingtools #sciencenews #breakthrough

At Biortus, our scientists are driven by innovation. To support this, our structure determination platform offers Microcrystal Electron Diffraction (MicroED) services—a powerful technique used to resolve the high-resolution structure of small molecule compounds. MicroED combines the principles of crystallography with the applications of CryoEM. Interested in MicroED? We're currently offering a discount on our MicroED services. To inquire, email us at info@biortus.bio or busdev@biortus.bio. You can visit our website to learn more about our capabilities and how we can support your drug discovery work. #smallmolecule #MicroED #CryoEM #crystallography #drugdiscovery

A Milestone in Plasma Diagnostics! Excited to share our latest article in Plasma Sources Science and Technology: "Precision spectroscopy of non-thermal molecular plasmas using mid-infrared optical frequency comb Fourier transform spectroscopy." Using mid-infrared comb spectroscopy, we measured state-resolved spectra of multiple plasma-generated species. Our focus on hydrogen cyanide revealed highly non-thermal quantum-state distributions with distinct rotational and translational temperatures. This may suggest diverse energy relaxation pathways and state-specific formation routes of hydrogen cyanide within non-thermal plasmas, which are important for industrial applications! Read more: https://lnkd.in/eC22R9HV #MolecularPlasmas #CombSpectroscopy #IndustrialPlasmaProcesses

Researchers have developed soft polymeric microrobots for diverse applications like microscale assembly, targeted therapeutics, microsurgery, and wastewater cleanup. Operating these microrobots in aquatic environments faces challenges due to viscous resistances and limited actuation and sensing capabilities. To overcome this, a study introduces magnetized microrobots with artificial cilia for stable acoustic propulsion and magnetic field-guided navigation. This acousto-magnetic strategy leverages precise magnetic orientation and strong acoustic thrust, addressing the hurdles of untethered manipulation in microscale environments. Read more details: https://lnkd.in/eUZq7GTg #polymerscience #softrobotics

A chances to learn all about the VERLO Image-Guided Cell Sorter! Explore the future of image-guided cell sorting with us and learn about the morphological features you can sort on with VERLO and applications for cell research like label-free sorting, cell-cell interactions, organelle staining, and more. Register for either one below! 👇 Wednesday, Oct. 2 @ 8:00 AM PDT / 11:00 AM EDT: https://buff.ly/3BcQEfD #GentleCellSorting #FlowCytometry #ImagingCytometry #Webinar

A chances to learn all about the VERLO Image-Guided Cell Sorter! Explore the future of image-guided cell sorting with us and learn about the morphological features you can sort on with VERLO and applications for cell research like label-free sorting, cell-cell interactions, organelle staining, and more. Register for either one below! 👇 Wednesday, Oct. 2 @ 8:00 AM PDT / 11:00 AM EDT: https://buff.ly/3BcQEfD #GentleCellSorting #FlowCytometry #ImagingCytometry #Webinar

#AML with inv(16) sequenced by #WGS (30-100x) on three different #NGS platforms--Illumina NovaSeq X+, PacBio Revio, and Oxford Nanopore PromethION. All three platforms easily identify the inversion as you can see from the soft clipped reads in the IGV screenshots below. Can you figure out which screenshot belongs to each instrument?

Excited to present my scientific poster-Detecting MMP-9-an aptasensing approach. In this work, we developed an electrochemical aptasensor for ultrasensitive detection of matrix metalloproteinase-9 (MMP-9) in human serum and saliva samples. #RSCposter #RSCAnalytical #RSCNano #RSCNano #RSCMat #Biosensor #Aptasensors #proteindetetction #cancerdetection #Bioelectronics