Vesiculab’s Post

View organization page for Vesiculab, graphic

8,342 followers

Designing surface-bioengineered extracellular vesicles to target lung cancer cells: in their latest work, Ireneusz P. Grudzinski and Anna M. Nowicka at University of Warsaw and collaborators bioengineered extracellular vesicles from lung cancer cells, decorating them with the heptapeptide PTHTRWA, the most effective peptide for binding to lung cancer cells. https://lnkd.in/eHukjPtd Preclinical safety assays revealed no cytotoxic or genotoxic effects of these novel bioconstructs, though impedance-based studies indicated some transient impacts on endothelial barrier integrity. An article co-authored by Agata Kowalczyk, Damian Dziubak, Artur Kasprzak, Kamil Sobczak, Monika Rużycka, Magdalena Bamburowicz-Klimkowska, Slawomir Sek, Ivan Rios Mondragon, Teresa Żołek, Elise Rundén Pran, Sergey Shaposhnikov, Mihaela Roxana C. and Maria Dusinska #extracellularvesicles #exosomes #bioengineering #lungcancer #clickchemistry #Vesiculab

  • Top image: TEM images of nonfunctionalized EVs (A–D), PTHTRWA-EVs (E–H), and EVs-PTHTRWA (I–L).
Bottom image: Possible optimized structures of heptapeptide anchored to the EV surface through its N- and C-terminus ends.

Thanks for the very useful information or article.

To view or add a comment, sign in

Explore topics