Bacteria-derived extracellular vesicles stimulate tumor growth in renal cell carcinoma: in this work, Kentaro Jingushi, Atsunari Kawashima and collaborators at Osaka University conducted 16S rRNA metagenomic analysis on bacterial DNA present in serum extracellular vesicles from healthy donors and renal cell carcinoma patients, identifying Cutibacterium acnes DNA as a distinctive bacterial component https://lnkd.in/eHMyUNve Their findings indicate that extracellular vesicles released by C. acnes present in renal cell carcinoma tissues exert tumor-promoting effects. An article also authored by Sayaka Tanikawa, Takuro Saito, Akinaru Yamamoto, Toshihiro Uemura, Nesrine Sassi, Yu Ishizuya, Yoshiyuki Yamamoto, Taigo Kato, Koji Hatano, Hiroaki Hase, Norio Nonomura and Kazutake Tsujikawa #extracellularvesicles #OMV #bacteria #carcinoma #Vesiculab
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Shares in ANGLE PLC (AIM:AGL, OTCQX:ANPCY) were up 4% in early trading after a move by health chief in the UK highlighted the potential of its technology. It emerged on Friday that lung cancer sufferers will be offered a pioneering blood test that will potentially fast-track them to targeted therapies that can be less harsh than traditional treatments. Used will be a liquid biopsy system that picks up circulating tumour DNA, allowing doctors to better understand the progression or mutation of the disease. While ANGLE's Parsortix technology isn't the same, it performs a very similar function in that it picks up circulating tumour cells associated with cancers for analysis. #AIM #OTCQX #AGL #ANPCY More at #Proactive #ProactiveInvestors http://ow.ly/Wg0p105mXB4
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Exploring New Options in Tumor Research 🧬 A recent study reveals that ICH1132 is a promising alternative to The standard in tumor research. Developed by ichorbio, this low endotoxin rat anti-mouse PD-1 antibody has shown significant early-stage efficacy, especially on days 14, 17, and 19 of the study. Why is ICH1132 noteworthy? 🌟 👉 Early-Stage Efficacy: Demonstrates substantial tumor growth inhibition early in the study. 👉 Consistent Performance: Shows a trend toward higher tumor growth inhibition compared to Competitor B. 👉 Lower Endotoxin Levels: Features lower endotoxin levels (0.013 EU/mg) which may be advantageous in specific research settings. 👉 Similar Safety Profile: Exhibits comparable effects on body weight, suggesting similar tolerability to current standards. Learn More: https://lnkd.in/e4VXBMz7 #rmp1-14 #CancerResearch #InnovationInScience #invivoantibodies
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TCR sequencing of different morphologically defined zones in pancreatic tumor tissue before and after ex vivo TIL expansion reveals that some zones exhibit stark differences in clone diversity after expansion. However, other zones have a ‘frozen’ TCR repertoire, similar to the initial tumor tissue. Learn more about this case study and how TCR repertoire sequencing from iRepertoire provides insights into the TME in this on-demand webinar: https://hubs.li/Q02GzpLG0 #TILs #Tcells #TumorMicroenvironment #EpthelialCancer #TcellReceptor #CellTherapy #TCRSequencing #TumorCells #CancerResearch
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TCR sequencing of different morphologically defined zones in pancreatic tumor tissue before and after ex vivo TIL expansion reveals that some zones exhibit stark differences in clone diversity after expansion. However, other zones have a ‘frozen’ TCR repertoire, similar to the initial tumor tissue. Learn more about this case study and how TCR repertoire sequencing from iRepertoire provides insights into the TME in this on-demand webinar: https://hubs.li/Q02Gz8R60 #TILs #Tcells #TumorMicroenvironment #EpthelialCancer #TcellReceptor #CellTherapy #TCRSequencing #TumorCells #CancerResearch
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Check out the latest research that could lead to promising therapeutic approaches for glioblastoma (GBM). Congratulations to Prof. Tsung-I Hsu’s team for demonstrating the potential of combining progesterone (Prog) with abiraterone (Abi) to enhance the treatment of temozolomide (TMZ)-resistant glioblastoma. The combination therapy significantly lowered the IC50 of Abi in resistant GBM cells, enhancing cytotoxicity and inducing greater apoptosis compared to either agent alone. Moreover, this approach suppressed tumor growth, extended survival in mouse models, and promoted an anti-tumor immune microenvironment by increasing NK cell infiltration. In this study, NK-92 cell viability was assessed using our automated cell counter, FACSCOPE® B. We appreciate that FACSCOPE® B was a part of this research. To read the full article: https://lnkd.in/d6hkgjGs More information about FACSCOPE® B: https://lnkd.in/gQ6SBw-H #curiosis #cellcounting #FACSCOPE #Curiosis #glioblastoma #progesterone #abiraterone #NK
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In this study, NK-92 cell viability was assessed using our automated cell counter, FACSCOPE® B.
Check out the latest research that could lead to promising therapeutic approaches for glioblastoma (GBM). Congratulations to Prof. Tsung-I Hsu’s team for demonstrating the potential of combining progesterone (Prog) with abiraterone (Abi) to enhance the treatment of temozolomide (TMZ)-resistant glioblastoma. The combination therapy significantly lowered the IC50 of Abi in resistant GBM cells, enhancing cytotoxicity and inducing greater apoptosis compared to either agent alone. Moreover, this approach suppressed tumor growth, extended survival in mouse models, and promoted an anti-tumor immune microenvironment by increasing NK cell infiltration. In this study, NK-92 cell viability was assessed using our automated cell counter, FACSCOPE® B. We appreciate that FACSCOPE® B was a part of this research. To read the full article: https://lnkd.in/d6hkgjGs More information about FACSCOPE® B: https://lnkd.in/gQ6SBw-H #curiosis #cellcounting #FACSCOPE #Curiosis #glioblastoma #progesterone #abiraterone #NK
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“Captain T Cell is devoted to developing a new generation of toolbox-engineered T cell-based immunotherapies for solid tumor patients. We have the utmost confidence in the expertise of Charles River as we work to bring our lead candidate to the clinic.” Felix Lorenz, CEO, Captain T Cell Once infused into a patient’s body, these tumor-specific T cells seek to find and destroy tumor cells and may provide an alternative for patients with tumors that no longer respond to other therapies. Read the story in full: https://okt.to/3YB50x #genemodifiedcelltherapy #genetherapy #tcelltherapy #immunotherapy #viralvectors
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Latest issue online!📲 LINC00606 promotes #glioblastoma progression through sponge miR-486-3p and interaction with ATP11B -------------- LncRNAs regulate tumorigenesis and development in a variety of cancers. Here Wang et al. substantiate for the first time that LINC00606 is considerably expressed in glioblastoma (GBM) patient specimens and is linked with adverse prognosis. This suggests that LINC00606 may have the potential to regulate glioma genesis and progression, and that the biological functions and molecular mechanisms of LINC00606 in GBM remain largely unknown. Check it out here👇 https://lnkd.in/ditJVRiN #GliomaCell #LongnoncodingRNA IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano
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“Captain T Cell is devoted to developing a new generation of toolbox-engineered T cell-based immunotherapies for solid tumor patients. We have the utmost confidence in the expertise of Charles River as we work to bring our lead candidate to the clinic.” Felix Lorenz, CEO, Captain T Cell Once infused into a patient’s body, these tumor-specific T cells seek to find and destroy tumor cells and may provide an alternative for patients with tumors that no longer respond to other therapies. Read the story in full: https://okt.to/8ivlPC #genemodifiedcelltherapy #genetherapy #tcelltherapy #immunotherapy #viralvectors
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Senior Research Fellow, life science, Cell Biology
5moWhen we thought that taking the whole patient into account would help understand and cure cancer, it meant the whole ecosystem. Probably some work is needed to go beyond diagnostic with this.