VIB’s Post

🔬 Are you a researcher focused on protein-protein interactions? MolBoolean™ offers several advantages over traditional methods. Do not miss the webinar! 👉🏼 Register here: https://ow.ly/iL0V50TcmBW 🔜 Learn about the design and development of MolBoolean™ by Atlas Antibodies which enables the simultaneous determination of protein amounts and their interactions within fixed cells and tissues, overcoming the limitations of existing methods such as in situ PLA. 🔍 Discover more here: https://ow.ly/WGug50TcmBQ #MolBoolean #webinar #neuroscienceresearch #cancerresearch #proteininteractions #proximityligation #proteomics #scientificdiscovery

🔬 Unlocking the Secrets of Protein Degradation! 🔍 In the latest from Science Advances, researchers delve into the promising world of small-molecule degraders, a game-changer for targeting disease-driving proteins. This groundbreaking study sheds light on how stable degrader-mediated complexes can transform therapeutic efficacy and address previously untouchable targets. 💊 By exploring intricate cryo-EM structures, the team uncovers how the degrader MZ1 collaborates with VHL Cullin 2 RING E3 ligase to effectively usher the target protein Brd4 towards ubiquitination. The strategic positioning of lysines reveals a crucial "ubiquitination zone" that paves the way for targeted protein degradation. 🔎 This research offers a mechanistic blueprint that could revolutionize drug design, opening new avenues for tackling complex diseases with precision. A promising leap toward the future of medicine! 🌟 Read Research 👉🏻 https://lnkd.in/d2ysFFmJ #research #pubmed

Excited to share insights from the "Nanotoxicity: A Challenge for the Future" webinar hosted by Heredity Biosciences, featuring Dr. Piyush Kumar Gupta 🇮🇳 . Key takeaways which were interesting and new for me: 1.) Understanding types of nanomaterials: natural, incidental, and engineered. 2.) Physiochemical properties contributing to nanomaterials toxicity. 3.) Routes of nanoparticle exposure and their interactions. 4.) Ex-Vivo models using organoid models for nanotoxicity analysis. 5.) Various toxicity tests employed, including LDH assay, flow cytometry, and more. 6.) Challenges in Organoid technology and its relevance in toxicity assessment. 7.) Computational and Experimental approaches in toxicity assessment. 8.) Importance of tools in nanotoxicity analysis. 9.) Discussion on nanotoxicity's implications on human health. Happy to be a part of this Webinar. #Nanotoxicity #Bioinformatics #WebinarInsights #HeredityBiosciences #DrPiyushKumarGupta

Need quick and easy sequencing in the Biozentrum, University of Basel? It is now possible! 🚀 We're thrilled to announce that the Biozentrum Nanopore is now accessible to all! Thanks to pioneers Valentin Druelle, PhD , Leonardo Lemos Rocha and Pablo Manfredi for setting up, optimizing the pipeline and for their continuous support! A shout out to Valentin Druelle, PhD for summing it up here: 🧬Relatively cheap 🧬gDNA sequencing -> can be used for methylation detection 🧬Long reads -> assemblies are (near) perfect 🧬Single reads are ~Q26 🧬Suitable for bacteria, plasmids, bacteriophages, amplicons, etc... About the Nanopore station itself: 🧬Now part of the Biozentrum FACS Core facility on 10th floor, Q2, Rm 10.040 🧬Offers a do-it-yourself and on site sequencing solution, complementary to external sequencing approaches 🧬Manipulation time is around 2.5-3.5 hours for 24 samples sequenced 🧬Relatively simple process. How to step-by-step Guide on Biozentrum wiki page, thanks to Valentin Druelle, PhD. Tag along with users and see how it flows! We would like to thank Prof. Richard Neher for initiating the project and Prof. Urs Jenal for proposing the move of the Nanopore to the Biozentrum FACS Core Facility. Have questions or suggestions? Comment or reach out to share your thoughts! #Genomics #Nanopore #Biozentrum #Sequencing

At NIBIB, Manu Platt spearheads research aimed at understanding how to reverse tissue degradation in sickle cell disease and other conditions. Platt and his lab, MATRICES, blend biochemical and bioengineering methods to reveal novel insights that would be difficult to glean through either approach alone. Head over to the NIH Record to get up to speed on some of their most impactful findings: https://lnkd.in/eMbEVYbd #SickleCellDisease #BiomedicalEngineering

Exciting Research Alert! Join us at #RSCPoster Conference 2024 as we unveil our groundbreaking work on "Why long-scale MD simulation? Insights from the discovery of novel B, C-ring truncated deguelin derivatives for cancer treatment"! Curious about the journey to designing deguelin derivatives with reduced side effects? We've delved deep into the realm of cyclin D1 and cyclin E inhibitors, exploring a series of B, C-ring truncated derivatives. Our research applies cutting-edge drug-like filters such as REOS and PAINs series, followed by rigorous molecular docking using Schrodinger software. But wait, there's more! We've embarked on a journey of long-scale MD simulation to unravel the binding stability of deguelin and its derivatives. Our dynamic study unveils fascinating insights – while all compounds exhibited stability during 100ns of MD, a surprising twist was observed in the CyclinD1-Deguelin complex. At 120ns, Deguelin shifted its position, binding to another cavity of the receptor. This highlights the necessity of long-scale MD simulation to capture real structural and conformational changes. Don't miss out on this captivating exploration at #RSCChemBio! We're eager to share our findings and discuss your burning questions. Read related article from this study: https://lnkd.in/gK5v5dgn Google Scholar: https://lnkd.in/grv4xZ7W #Research #Science #CancerTreatment #MDsimulation

Scientific Founder Holger Heyn does it again!🚀 Dr. Heyn’s latest publication represents years of collaborative effort dedicated to unraveling complexities of the human tonsil. The Human Tonsil Cell Atlas identifies 121 distinct cell types and states, mapping developmental pathways and enhancing our understanding of tonsil function. By stratifying subtypes, pinpointing active enhancers/ transcriptional regulators, and confirming age-related changes in tonsil composition, this comprehensive census of cell types and states is poised to make a significant impact. Ultimately, by facilitating the identification of normal vs diseased cells, the atlas holds vast clinical potential, fosters therapeutic advancements, and aids novel target discovery. 🗞️ https://lnkd.in/dTXCjmT4 #ScienceIsWeAll

Thank you for sharing this impressive Human Tonsil Cell Atlas that identifies 121 distinct cell types and states, mapping developmental pathways and enhancing our understanding of tonsil function. Although there must be some cell type plasticity (interconnected conversions from one to another cell type) there is enough information to identify complex cell types and circumstantial cell functions. But not enough to answer for example whether it is good or bad to perform (when ?) a tonsillectomy, especially in children. Once a rather fashionable (in many countries) but traumatic surgical intervention. By stratifying subtypes, pinpointing active enhancers/ transcriptional regulators, and confirming age-related changes in tonsil composition, this comprehensive census of cell types now described might help design better studies and provide more accurate information on the global biological and clinical consequences of these surgeries? See: ORIGINAL RESEARCH article-Long-term complications after tonsil surgery: an analysis of 54,462 patients from the Swedish Quality Register for Tonsil Surgery Front. Surg., 12 December 2023 Sec. Otorhinolaryngology - Head and Neck Surgery Volume 10 - 2023 | https://lnkd.in/dM5fmS7k

🚨 Exciting Preprint Alert! 🚨 Our latest research presents a multiscale coupling approach for understanding complex biological systems like the liver. Our study presents a multiscale digital twin of the liver, seamlessly integrating partial differential equation-based models with cellular-scale ordinary differential equation-based models. This innovative approach enables us to explore hepatic functions and responses across various scales - from individual cells to lobules. Key Findings: 1) Investigation of perfusion-zonation-function relationships in the liver. 2) Exploration of protein zonation patterns and their impact on metabolic processes. 3) Analysis of drug concentration effects on spatially heterogeneous liver damage, mimicking drug-induced liver injury 🩸. The integration of domain-specific simulators using standard exchange formats ensures reproducibility and facilitates collaboration across research teams. Dive deeper into our findings and methodologies by checking out our preprint and navigate through the results under 🌐 https://lnkd.in/e32ssRjc! You can find the whole preprint on biorxiv 🧬: https://lnkd.in/ek8Hj_y3

Led by Jin Kim Montclare and her team, #NYUTandon researchers have published a study focusing on the design and development of a novel protein capable of binding to the spike proteins found on the surface of the coronavirus. The goal behind this innovative approach is twofold: first, to identify and recognize the virus for diagnostic purposes, and second, to hinder its ability to infect human cells. The study marks a significant advancement in the fight against COVID-19, showcasing a multifaceted approach to combating the virus. Through a combination of protein engineering and computational design, the team has devised a promising strategy that may revolutionize current treatment modalities. Click the link to learn more about this research. #NYUTandonMade https://buff.ly/4abnQ3d