JULY is #Sarcoma Awareness Month 📣 💡 Check out this video from #ASCO2024 | Overview of managing #CNS #metastases in #pediatric #Ewingsarcoma🎥 Leonora Slatnick, MD, University of Utah provides an overview of managing #centralnervoussystem (CNS) #metastases in #pediatric patients with #Ewingsarcoma (ES) The lack of standardized management and the poor outcomes for these patients are highlighted 📉 Although outcomes may differ from other metastatic or relapsed diseases, the small cohort size makes it unclear One case involved a patient with incomplete resection who underwent high-dose #chemotherapy with #stemcell rescue and achieved long-term survival, which is unusual 🔦 Learn more 👉 https://lnkd.in/dm347SnH #VJOncology #Oncologynews #SarcomaAwarenessMonth
Video Journal of Oncology (VJOncology)’s Post
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🔬🧬 Innovative Insights into MRD Detection and Risk Stratification for Pediatric AML via ctDNA #AML #PediatricOncology #ctDNA In this enlightening interview, Professor Xiaofan Zhu discusses cutting-edge methods for MRD detection and risk stratification in pediatric AML, highlighting the promising role of ctDNA testing. #InnovativeResearch #CancerCare #LeukemiaResearch
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Recent study reveals critical insights into Pediatric Hepatocellular Adenomas (HCAs). Predominantly affecting girls, these benign liver tumors often develop due to conditions like glycogen storage disease, portosystemic shunts, or hormone exposure. Although generally benign, HCAs pose significant risks, with about 25% leading to bleeding and 15% to malignant transformation. Management strategies include vigilant monitoring and, if necessary, surgical interventions such as resection or liver transplantation to handle complications. This study underscores the importance of personalized treatment plans based on the specific predisposing factors. 🌟🔬 #HealthcareInnovation #PediatricOncology
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Final Year Medical Student | Aspiring Cardiothoracic Surgeon | Passionate about Advancing Healthcare
🔬📄 Thrilled to share our latest publication on Childhood Cerebral Adrenoleukodystrophy (ALD) in the journal Degenerative Neurological and Neuromuscular Disease! 🚀🧠 Our case report highlights the urgent need for newborn screening (NBS) for ALD, particularly in regions where it is not yet implemented. We discuss a case of a 10-year-old boy whose condition rapidly progressed despite symptomatic management. The paper emphasizes the need for global implementation of NBS and continuous pediatric neurologic follow-up. 🌍👶🩺 Read the full article here: https://lnkd.in/gxaCZFnX #MedicalResearch #Neurology #Genetics #ALD #NewbornScreening #Pediatrics #HealthcareInnovation #ScientificBreakthrough 🔬📚🧠
Childhood Cerebral Adrenoleukodystrophy: Case Report and Literature Review Advocating for Newborn Screening
tandfonline.com
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We are pleased to announce the publication of a review article entitled "Advances in the approaches used to repurpose drugs for neuroblastoma" by the Neural Tumors laboratory in the journal Expert Opinion on Drug. The review, led by Dr. Miquel F Segura, provides insight into the essential strategies for developing new therapies against neuroblastoma. It also underscores the significant challenges posed by this pediatric tumor, given that only one new treatment has been approved in the last 30 years. Marta Miera Maluenda and the other contributors are to be commended for their work on this compilation of advances in neuroblastoma research over the past decades. #publication #scientific #scientificarticle #pediatric #congrats #congratulations #achievement #study #potential #therapeutic #patients #paper #childhood #childhoodcancer #child #children #cancer #pacientes #salud #healthcare #hospital #clinicaltrials #clinics #trials #drug #innovative #therapies
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Evidence Synthesis | Market Access | Medical Writer | Operational Efficiency
I am excited to share Maple Health Group, LLC's latest publication in which I am a co-author! This SLR evaluates the current evidence base regarding the treatment of pediatric classical Hodgkin's Lymphoma in the United States. Although, it generally has a high overall survival rate, the toxicity and long-term effects of treatment over a patients life time are of great concern. The current evidence shows that a greater proportion of patients achieved 3-and 5-year progression/event free survival when treated with a brentuximab vedotin (BV) containing regimen. BV is a antibody conjugate therapy that provides a more targeted treatment, potentially reducing the need for subsequent rounds of chemotherapy. This is a promising finding as we continue to improve upon therapeutics options in this precious population.
In collaboration with Seagen, Inc (now Pfizer), Maple Health Group, LLC is pleased to announce our recent publication in Pediatric Blood & Cancer! A comprehensive systematic literature review of US studies for the treatment of pediatric classical Hodgkin lymphoma (cHL) revealed that a greater proportion of pediatric patients with cHL were able to achieve 3- and 5-year event/progression free-survival when treated with brentuximab vedotin containing regiments releative to other chemotherapy treatments across comparative (n=2) and non-comparative (n=6) studies. Treatments that effectively reduce a patient's likelihood for disease progression, mitigate the need for subsequent treatments that often increase in intensity/toxicity and/or invasiveness. Congratulations to Maple consultants Chris Waters-Banker, PhD and Rachel Beckerman, as well as their co-authors, on this important publication. Link to publication provided in the comments. #pediatrics #cHL #HodgkinLymphoma #Maple #SLR #EvidenceSynthesis
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Join us next week to hear the latest pediatric #HighGradeGlioma research and clinical trial updates from PNOC's expert scientific panel. Register to receive the zoom link: https://lnkd.in/gXFT5hMs - this webinar will be available live with a Q&A or on demand if you cant make it in real time. #braincancer #pediatriccancer #pediatricbraincancer #glioma #gliomas #braintumor #cancerresearch
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🌍 Today on World Ovarian Cancer Day, May 8th, we remind everyone about the importance of early detection in fighting ovarian cancer. Symptoms often include bloating, pelvic or abdominal pain, and difficulty eating or feeling full quickly. 🔍 Early detection is key. Don't wait to seek help if you're experiencing symptoms. Consult with our expert obstetrics and gynecologists at International Modern Hospital for a thorough checkup. 👩⚕️ To schedule your consultation: https://lnkd.in/d6MED-DP #WorldOvarianCancerDay #EarlyDetection #WomensHealth #Gynecology
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I am pleased to share our latest publication in the European Journal of Medical Genetics: "Cardiovascular abnormalities in patients with SHANK3 pathogenic variants: Beyond neurodevelopmental disorders and epilepsy." 🫀📚 This study provides new insights into the cardiovascular risks associated with SHANK3 pathogenic variants, underlining the importance of comprehensive cardiac evaluations for these patients. A big thank you to my co-authors for their dedication and hard work! 👏 Lucy Dougherty de Miguel, Alícia Artigas Baleri, Laia Turón, Ivon Cuscó, Asun Díaz, Luísa Panadés de Oliveira and Susana Boronat. Read the full article here: https://lnkd.in/dV8ynGxw #PediatricCardiology #Genetics #Cardiomyopathy #Research #NeurodevelopmentalDisorders #Pediatrics
Cardiovascular abnormalities in patients with SHANK3 pathogenic variants: Beyond neurodevelopmental disorders and epilepsy
sciencedirect.com
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𝐔𝐧𝐥𝐨𝐜𝐤 𝐭𝐡𝐞 𝐬𝐞𝐜𝐫𝐞𝐭𝐬! 𝐉𝐨𝐢𝐧 𝐮𝐬 𝐚𝐭 𝐭𝐡𝐞 𝟑𝐫𝐝 𝐀𝐫𝐚𝐛 𝐓𝐡𝐲𝐫𝐨𝐢𝐝 𝐂𝐨𝐧𝐠𝐫𝐞𝐬𝐬 𝐭𝐡𝐢𝐬 𝐲𝐞𝐚𝐫 𝐚𝐧𝐝 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐰𝐡𝐚𝐭'𝐬 𝐢𝐧𝐬𝐢𝐝𝐞 𝐭𝐡𝐞 𝐩𝐫𝐨𝐠𝐫𝐚𝐦. Get ready to delve into cutting-edge research, innovative treatments, and invaluable insights. Don't miss out & Register Now: https://lnkd.in/de73Xy7C #thyroidhealth #thyroidproblems #thyroiddisease #endocrinology #internalmedicine #surgeons #pediatricians #oncology
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How can #Bayesian borrowing approaches enhance the statistical analysis of #baskettrials and #pediatric studies and what impact could these methods have on the evaluation of treatment efficacy in #rare indications? Emma Mackay from Inka Health, will be presenting at the Statistical Society of Canada / Société statistique du Canada Annual Meeting at Memorial University, Newfoundland and Labrador tomorrow afternoon in Room C2045. The session is organized by Aaron Springford from AstraZeneca and will be chaired by Audrey Béliveau from University of Waterloo. https://lnkd.in/gxw2iJEz In her talk, Emma will address the pressing challenges in evaluating efficacy for rare indications, focusing on the application of Bayesian hierarchical models, power priors, and meta-analytic predictive priors. These innovative approaches facilitate dynamic borrowing of information, improving statistical precision and power in #clinicaltrials where patient recruitment is a significant hurdle. Emma's discussion will include practical recommendations, such as leveraging historical control arms and integrating data from adult populations to support #pediatrictrials. Her insights into #baskettrials, which recruit patients based on shared #biomarkers across multiple disease types, highlight the potential for more efficient and effective #research. #BayesianMethods #ClinicalTrials #clinicaltrial #RareDiseases #BasketTrials #PediatricResearch #StatisticalInnovation #EfficacyEvaluation #DynamicBorrowing #DataScience #oncology #SSC2024 #HealthcareAnalytics #PrecisionMedicine #BayesianBorrowing #MedicalResearch #PatientCare #SSC #MemorialUniversity #pediatrics
Bayesian borrowing approaches to address the challenges of evaluating efficacy/effectiveness in rare indications: applications to basket trials and pediatric studies
ssc.ca
