vinodhini Jayananthan’s Post

EARLY VIEW - Wiley Online Library Central role of pro-IGFII(68–88) (big IGFII) in the pathogenesis nonislet cell tumour-induced hypoglycaemia https://lnkd.in/eCUbRfEk ✍️ Robin P. F. Dullaart @researchumcg Keywords: #hypoglycaemia #insulinlikegrowthfactorII #solitaryfibroustumour Nonislet tumour-induced hypoglycaemia; pro-IGFII(68–88)

In our latest publication, we (Julie Sesen, PhD and colleagues) investigated the role of the axon guidance factor Ephrin B2 and its receptor EphB4 in Cerebral cavernous malformations (CCMs). For the first time, we are providing evidence that Ephrin dysregulation to be implicated in CCMs and revealing a putative therapeutic target. https://lnkd.in/dhnJWM2a

https://lnkd.in/efBP5KAK Great to see our hCD68-GFP transcriptomics studies on PubMed, well done Gareth, Eileen and Ben. Interesting implications for the role of monocytes and macrophages in inflammation and more great chemotaxis experiments!

Thanks Stefania de Vito, PhD and ECTRIMS for featuring our recent Springer Nature Group article identifying a novel mitochondrial complex I-driven (not complex II 😆) mechanism of persistent microglia activation and revealing its impact in the context of #smolderinginflammation and #progressiveMS | with Luca Peruzzotti-Jametti and University of Cambridge

At #ACC24, a groundbreaking innovation in cardiovascular medicine was showcased - #ArtificialIntelligence (AI). Ami Bhatt, the Chief Information Officer at ACC, provided an insightful overview of AI's applications in #CardiovascularDisease, highlighting its use to synthesize large amounts of data to optimize risk prediction and clinical decision-making. Her overview sparked ideas on how AI can optimize and accelerate clinical development in gene therapy for CV and rare diseases. AI can revolutionize the field by identifying optimal candidates for gene therapy, determining the best timing for gene therapy, and informing strategies for managing gene therapy-associated toxicities. Let's explore how we can apply this pioneering innovation to increase the safety and efficacy of gene therapies and get these important new treatments to patients more quickly. #AIinMedicine #genetherapy

Searching for functional iPSC-derived cardiac cells for cardiac research and cardiotoxicity screening: We’ve produced a comprehensive overview of our in vitro cardiotoxicity and cardiac research offerings including: 💗 Why the drug discovery industry is increasing investment into in vitro models 💗The key highlights of our axoCells ventricular and atrial cardiomyocytes, including characterization and functional data 💗How we can support your cardiac research with our custom axoServices lab services Two exciting concepts that we’re exploring to improve the purity and maturity of iPSC-derived cardiomyocytes for in vitro cardiotoxicity models 💗Examples of our work in the cardiac space, including the external CiPA validation of our ventricular cardiomyocytes and chamber-specific responses of our atrial and ventricular cardiomyocytes Learn more about the first choice in iPSC-derived models from Axol Bioscience with our 2024 cardiac guide https://lnkd.in/eWWWV_-s #cardiotoxicity #ipscs #betterhumandiseasemodels

Another paper out! I am very proud of this paper where we investigated the effect of proton therapy on microglia. Check out the paper or the graphical abstract below!

Real-time cell health monitoring is transforming scientific research. In this article, Promega research scientists highlight how live-cell kinetic assays are transforming our understanding of cell dynamics and serving as a valuable tool for studying cellular responses to external stimuli. Learn about the benefits of real-time data and how it can lead to more efficient scientific outcomes https://lnkd.in/eKSwAukt

Interesting example of taking a transcriptome-level workflow and deriving therapeutically relevant insights. The ever-present big question - will it translate? In this case, senolytic agents that "selectively remove" dysfunctional nociceptors in the setting of chronic pain with (apparently) few off target effects [in mice] - is it, as the authors put it, a worthwhile trade-off or will there be as-yet unknown impacts on peripheral nerve function after a selective culling of maladapted cells?

#PaperoftheDay: "MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression" DOI ⬇️ https://lnkd.in/ekBsT6tg #osteosarcoma #aging #research #openaccess #peerreview #publishing