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🔬💉 The mRNA Vaccine Revolution 2.0: What's Next? 🚀 Hey Innovators & Pioneers! If you thought mRNA technology peaked with COVID-19 vaccines, brace yourselves—the next wave is surging towards us. According to a brilliant piece from MIT Technology Review, scientists are not resting on their laurels. They're pushing the envelope with the next generation of mRNA vaccines that could be even more groundbreaking than the first. Imagine vaccines that are more robust, targeting everything from multiple flu strains in one go to daunting foes like malaria and tuberculosis. These aren't distant dreams; they're on the doorstep of medical science. And it's not just infectious diseases; mRNA tech could revolutionize cancer treatments, too—personalized vaccines that train our bodies to hunt down and destroy cancer cells. What's truly jaw-dropping? The speed and flexibility of this technology. Gone are the days of decade-long vaccine development. We're talking about slashing timelines, rapid responses to emerging threats, and a new frontier in precision medicine. 🤔 So, I've got to ask my network: - How could next-gen mRNA platforms reshape our approach to global health crises? - What industries could be transformed by the lightning-fast adaptability of mRNA tech? This isn't just a scientific milestone; it's a turning point for healthcare technology that demands our attention and enthusiasm. Dive into the details and fuel your curiosity with the full article from MIT Technology Review: https://nuel.ink/o1fRnX Let's celebrate our relentless pursuit of innovation. If this fuels your passion for cutting-edge tech as it does mine, SMASH that FOLLOW and LIKE to join the conversation and stay informed on the latest breakthroughs that shape our world. Let's connect, discuss, and drive technology forward, together! #mRNARevolution #HealthcareInnovation #FutureOfMedicine 🧬💡🚀

The Crucial Role of mRNA in Revolutionizing Vaccine Production In the wake of the COVID-19 pandemic, the world witnessed a remarkable feat in vaccine development: the rapid creation of effective vaccines, with mRNA technology at the forefront. This groundbreaking approach has not only been instrumental in combating the current crisis but has also paved the way for a new era in vaccine production. mRNA vaccines work by introducing a small piece of genetic material from the virus into the body, instructing cells to produce a protein that triggers an immune response. This innovative approach offers several advantages over traditional vaccine technologies: Speed: Traditional vaccine development can take years, but mRNA vaccines can be rapidly developed. The mRNA sequence can be quickly synthesized once the genetic code of the virus is known, allowing for a faster response to emerging threats. Flexibility: mRNA vaccines are highly adaptable. They can be easily modified to target different variants of a virus, making them a valuable tool in the fight against evolving pathogens. Safety: mRNA vaccines do not contain live virus, so there is no risk of causing the disease in the vaccinated individual. They also do not interact with the host genome, further enhancing their safety profile. Efficacy: Clinical trials have shown mRNA vaccines to be highly effective, providing strong protection against COVID-19 and its variants. Production Scalability: The production of mRNA vaccines is relatively simple and scalable. Once the mRNA sequence is synthesized, it can be quickly manufactured in large quantities. The success of mRNA vaccines in combating COVID-19 has highlighted the immense potential of this technology in addressing other infectious diseases, cancer, and even genetic disorders. As we continue to battle the pandemic and prepare for future health challenges, it is clear that mRNA vaccines have revolutionized vaccine production and hold great promise for the future of medicine. High quality reagents have vital role to get succuss in vaccine development program. To get high quality reagents in unbeatable price contact us on sales@akonscientific.com www.akonscientific.com #mRNA #VaccineProduction #HealthcareInnovation #COVID19 #reagents

My vision of teamwork in the development of the SARS-CoV-2 vaccine. 😉 In the heart of a bustling research lab , an interdisciplinary team of scientists huddled around a table strewn with data charts, genetic sequences, and medical journals. Each member brought their unique expertise to the table – a biologist, a chemist, a pharmacologist, and a bioinformatician, among others – all united by their shared passion for combating infectious diseases. Their latest project was ambitious: to develop a novel drug targeting a rapidly emerging infectious pathogen. As they delved into the complexities of the pathogen's biology, it became evident that no single discipline held all the answers. They needed each other's insights to piece together the puzzle. The biologist shared her findings on the pathogen's mode of transmission, while the chemist proposed potential molecular targets for drug development. The pharmacologist offered expertise on drug formulation and toxicity, while the bioinformatician analyzed vast genomic datasets to identify vulnerabilities in the pathogen's genome. Despite their diverse backgrounds, the team worked seamlessly together, drawing inspiration from each other's perspectives and pushing the boundaries of their collective knowledge. They engaged in lively debates, challenged each other's assumptions, and celebrated breakthroughs together. Their strong teamwork skills were evident in their ability to communicate effectively, delegate tasks based on individual strengths, and adapt to unexpected challenges. When experiments failed or results were inconclusive, they rallied together, brainstorming new approaches and supporting each other through setbacks. Months of tireless collaboration culminated in a breakthrough: a promising vaccine candidate that showed potent activity against the infectious pathogen in preclinical trials. As they prepared to publish their findings, the team reflected on the power of interdisciplinary collaboration in promoting scientific progress. Their journey was a testament to the transformative impact of teamwork, demonstrating that by bridging the gap between disciplines and enjoying each other's expertise, they could overcome even the most formidable challenges in the fight against SARS-CoV-2. The COVID‑19 vaccines are widely credited for their role in reducing the spread of COVID‑19 and reducing the severity and death caused by COVID‑19. 😊

Evaxion launches improved AI-Immunology™ platform model for vaccine antigen prediction!   Today at ECCB, European Conference on Computational Biology, Evaxion has launched an enhanced version of its clinically validated AI-Immunology™ platform with an update of its EDEN™ AI prediction model. Among other improvements, the model can now accurately predict toxin antigens, allowing for development of improved bacterial vaccines 🦠💉   Bacterial toxins are often key contributors to disease, making their neutralization essential for developing effective vaccines. The upgraded EDEN™ model improves the prediction of broadly protective bacterial antigens for vaccine development. The launch will expectedly improve Evaxion’s ability to fast and effectively discover AI-derived novel vaccines and is expected to further solidify the strong interest seen in AI-Immunology™ from potential partners. #ECCB2024

🌟 Celebrating Breakthroughs in Vaccine Development! 💉 A big shout out to the team at Greenlight Biosciences for their paper titled "Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine." 🔍 Summary and Key Findings: The research team focused on addressing the increasing incidence of herpes zoster (shingles), which is caused by the Varicella Zoster Virus (VZV). Despite the availability of effective vaccines like Shingrix, shingles cases continue to rise globally, especially in underserved regions. To tackle this, the team evaluated three mRNA-LNP-based vaccine candidates targeting VZV’s surface glycoprotein E (gE). Their findings revealed that these candidates induced robust and enduring humoral and cellular immune responses, surpassing the efficacy of current standard vaccines. This underscores the potential of mRNA-LNP vaccines as a potent prophylactic solution against herpes zoster. While challenges remain, particularly in optimizing mRNA delivery, the development of lipid nanoparticles (LNPs) based on ionizable lipids, such as SM-102, represents a significant stride forward. SM-102’s enhanced delivery capabilities hold the key to overcoming barriers in mRNA therapeutics and expanding its applications across various fields, including cancer immunotherapy, gene editing, and vaccination. 🌐 Read more about their paper here:  https://lnkd.in/gBbyrX54 Explore SM-102 and BroadPharm's novel ionizable lipid portfolio here: 🔗 SM-102 —> https://lnkd.in/gycQ49TX 🔗 Other ionizable lipids —> https://lnkd.in/g8a-fmxv #ionizablelipid #drugdelivery #Nanoparticle #mRNA #LNP #Vaccine #SM102

After recently having a family member come down with Covid, I decided to make this week's post about mRNA vaccine technology. mRNA vaccines have transformed the way we think about immunization, offering new possibilities for faster, more adaptable treatments. I explore how mRNA vaccines work, the science behind their development, and how this technology could be applied to treat other conditions like cancer, genetic disorders, and autoimmune diseases. Read on to learn more about this groundbreaking technology and its future applications. #Biotech #MolecularBiology #Biologics #mRNAVaccine #Medicine #COVID19 https://lnkd.in/giMCXTzs

I'm thrilled to announce that work performed in our lab is part of the study titled "𝗜𝗺𝗺𝘂𝗻𝗼𝘀𝗲𝗻𝗲𝘀𝗰𝗲𝗻𝗰𝗲 𝗮𝗻𝗱 𝘃𝗮𝗰𝗰𝗶𝗻𝗲 𝗲𝗳𝗳𝗶𝗰𝗮𝗰𝘆 𝗿𝗲𝘃𝗲𝗮𝗹𝗲𝗱 𝗯𝘆 𝗶𝗺𝗺𝘂𝗻𝗼𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗼𝗳 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-𝟮-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗰𝗲𝗹𝗹𝘀 𝗶𝗻 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲 𝘀𝗰𝗹𝗲𝗿𝗼𝘀𝗶𝘀 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀", published in Nature Communications. 🔬🧠 🩺 💉 This publication marks a landmark collaboration between Biomedical Research Foundation of the Academy of Athens CyTOF Lab and Sara De Biasi, Domenico Lo Tartaro and Prof. Andrea COSSARIZZA from the Università degli Studi di Modena e Reggio Emilia,  in the exploration of how immune responses to COVID-19 vaccines are influenced by different disease-modifying therapies (DMTs) in patients with relapsing-remitting multiple sclerosis (MS). 🛠️💪 Leveraging the power of mass cytometry (Cytometry by Time-Of-Flight, CyTOF), we analysed T and B cell responses to the SARS-CoV-2 mRNA vaccine's third dose, focusing on cell phenotype, function, and metabolism. Leveraging the power of CyTOF with a 45-parameter panel, our study provides unprecedented insights into the T and B cell metabolic and phenotypic responses specific to SARS-CoV-2. 🌟 🔍 We've uncovered unique metabolic profiles that not only shed light on the effectiveness of various DMTs but also reveal potential pathways for enhanced protection against breakthrough infections. Our findings reveal that MS patients generally develop a robust immune response to the vaccine, with distinct metabolic profiles in SARS-CoV-2-specific T and B cells. This response was notably different in patients treated with Fingolimod and Natalizumab, unveiling a unique immunological signature that might be key in protecting against breakthrough infections. 🙏 A big shoutout to all co-authors, for their incredible contributions, dedication, and hard work. Our heartfelt appreciation also goes to the patients who donated their samples for this pivotal research. A big thanx also to Glòria Martrus Zapater and Paolo Santino from Standard BioTools for supporting this work and BioAnalytica S.A. for local support. 👉 Check the full article here: https://lnkd.in/das274jC. #Immunometabolism #VaccineEfficacy #MultipleSclerosis #HighdimensionalCytometry #CyTOF #BRFAA #UNIMORE #StandardBioTools #BioAnalytica

Does race have anything to do with genetics? No ! Part 3 How long does it take to make a vaccine for a virus? Typical Timeline. A typical vaccine development timeline takes 5 to 10 years, and sometimes longer. https://lnkd.in/dMEiuiRq. Can COVID-19 vaccines alter my DNA? No, COVID-19 vaccines do not alter your DNA. Some COVID-19 vaccine use a fragment of messenger RNA (mRNA) to instruct your body to make an immune response against COVID-19. There is a crucial difference between mRNA and DNA. https://lnkd.in/dYdF8Mku Potential health risks of mRNA-based vaccine therapy: A hypothesis Therapeutic applications of synthetic mRNA were proposed more than 30 years ago, and are currently the basis of one of the vaccine platforms used at a massive scale as part of the public health strategy to get COVID-19 under control. To date, there are no published studies on the biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life and inactivation kinetics of synthetic mRNA, rates and duration of vaccine-induced antigen expression in different cell types. Furthermore, despite the assumption that there is no possibility of genomic integration of therapeutic synthetic mRNA, only one recent study has examined interactions between vaccine mRNA and the genome of transfected cells, and reported that an endogenous retrotransposon, LINE-1 is unsilenced following mRNA entry to the cell, leading to reverse transcription of full length vaccine mRNA sequences, and nuclear entry. This finding should be a major safety concern, given the possibility of synthetic mRNA-driven epigenetic and genomic modifications arising. We propose that in susceptible individuals, cytosolic clearance of nucleotide modified synthetic (nms-mRNAs) is impeded. Sustained presence of nms-mRNA in the cytoplasm deregulates and activates endogenous transposable elements (TEs), causing some of the mRNA copies to be reverse transcribed. The cytosolic accumulation of the nms-mRNA and the reverse transcribed cDNA molecules activates RNA and DNA sensory pathways. Their concurrent activation initiates a synchronized innate response against non-self nucleic acids, prompting type-I interferon and pro-inflammatory cytokine production which, if unregulated, leads to autoinflammatory and autoimmune conditions, while activated TEs increase the risk of insertional mutagenesis of the reverse transcribed molecules, which can disrupt coding regions, enhance the risk of mutations in tumour suppressor genes, and lead to sustained DNA damage. Susceptible individuals would then expectedly have an increased risk of DNA damage, chronic autoinflammation, autoimmunity and cancer. In light of the current mass administration of nms-mRNA vaccines, it is essential and urgent to fully understand the intracellular cascades initiated by cellular uptake of synthetic mRNA and the consequences of these molecular events. https://lnkd.in/d8UGNCdB

In recent months, the internet has buzzed with a conspiracy theory dubbed "Plasmid-gate." Read our latest blog 'Plasmid-gate: Debunking the DNA contamination claims in mRNA vaccines' that addresses the accusations that are rooted in misunderstanding, faulty science, and alarmist rhetoric. Spoiler alert The truth about mRNA vaccine production COVID-19 mRNA vaccines may contain minuscule amounts of residual DNA from production processes, but these fragments are heavily degraded and pose no risk to human health. Proper testing shows safety Claims of DNA contamination often rely on inappropriate testing methods. Proper tests like qPCR reveal that any residual DNA is well within safety limits set by health authorities such as the WHO and FDA. Why DNA cannot alter your genes The idea that residual DNA can integrate into human DNA and cause cancer is biologically implausible. The vaccines cannot enter the cell nucleus. Our cells have robust mechanisms to eliminate foreign DNA. Debunking "turbo cancer" The fear of "turbo cancer" caused by DNA in vaccines is pure fearmongering. No scientific evidence supports the claim, and residual DNA in vaccines has not been linked to any increased cancer risk. Trusted science over fear Regulatory agencies worldwide, including the FDA and WHO, ensure vaccine safety. The claims behind Plasmid-gate rely on bad science and distortions, and they should not undermine public trust in life-saving vaccines. https://lnkd.in/gCxCRZf2

Accelerating vaccine development with transcriptomics From Genoskin – The landscape of vaccine development is undergoing a significant transformation with the advent of transcriptomic approaches. These technologies offer unprecedented insights into the complexities of the immune system, enabling the creation of more effective and targeted vaccines. #transcriptomics #RNAseq #vaccine #vaccinrdevelopment https://lnkd.in/dp9ayU6H