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To all #Ubiquitin, #UPS, #Proteasome and #TPD enthusiasts: We now offer a comprehensive human UPS #CRISPR library as part of our off-the-shelve portfolio at Vivlion. Key features: 👉 851 genes, essential, non-targeting and safe-harbor controls, 👉 total 3,416 gRNAs, gene list is available 👉 skew of 2.61  Don’t hesitate to reach out for a quote!   The utility of this type of library has only recently been proven in the discovery of a new modality in targeted protein degradation (#TPD), published in Nature (Hsia et al., 2024): An international research team led by Alessio Ciulli (CeTPD, University Dundee) and Georg Winter (CeMM, Vienna) , together with Manuel Kaulich, Martin Wegner, Dr. Dipl.-Bioinf., Koraljka Husnjak, and Ivan Đikić from Goethe University Frankfurt, defined the mode of action of a new class of bifunctional degraders termed intramolecular bivalent #glues (IBG) – a milestone in the field. They i.a. conducted a pooled #CRISPR screen utilizing #PRCISR technology to unravel IBG1’s mode of action.

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