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Too busy to read our Annual Report and discover about our first #results? Don't worry. We bring you some of our year's highlights in this post: 🥳 We identified some mechanochemical alternatives to three traditional, solvent-based reactions. All of these were viable at a lab scale, and we proudly presented them at IUPAC|CHAINS2023. 🧂In the field of multicomponent systems, like cocrystals and salts, our team has been working on different approaches towards one-pot synthesis. Mechanochemical methods could really simplify the manufacturing conditions for #pharma. 🔬 Our colleagues at CSGI are developing a novel form of spectroscopy, to unravel what goes on at a microscopic level when two ball mills collide. This is such an unique experimental setup! 🏃♀️ And our partners at Bundesanstalt für Materialforschung und -prüfung have worked on a model system to develop an experimental protocol. This systematic guide ensures that insights from the molecular level resonate across the project, enhancing the collective ability to harness kinetics for groundbreaking results. 💊 We also achieved the upscaling of the synthesis of a pharmaceutical cocrystal, combining ibuprofen and nicotinamide. The results are promising: we scaled things up to the kg range, at a conversion rate of 100%. 💚 Another major achievement for this first year involves applying the DOZN 2.0 Green Chemistry Evaluator to benchmark the batch process of pharmaceutical cocrystals against the Twelve Principles of Green Chemistry. Yep, green is our favourite colour. 🤝 And since we’re a collaborative bunch, we are building bridges with other projects. Our team has attended different congresses, presenting IMPACTIVE results. Particularly meaningful for us was the joint PREMIER and Transpharm workshop, held in The Netherlands last April. You can find the full document here: https://lnkd.in/efixDxi9
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Discover more about Serán’s science-first, technology driven approach to drug development and drug product design. Our Principal Engineer, Wesley Tatum, Ph.D, sat down with PharmTech to discuss what makes Serán's approach to formulation development a differentiator in our customer's success. Tune in to learn: ⌚ How Serán uses materials science experience to evaluate each project's compound limitations and timelines to establish a lead formulation early in Ph1 🤝How Serán’s partnership philosophy means we will actively work alongside you to meet project goals and timelines. 📏 How Serán applies a client-centric, scalable and flexible formulation design that supports your program as it advances Learn more and watch the interview: https://hubs.li/Q02gvd060
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I am really looking forward to attending the 8th RSC-BMCS Symposium on Mastering Medicinal Chemistry tomorrow on behalf of Domainex. There are lots of interesting talks lined up, all looking to share key learnings from both academia and industry. I am excited to learn more about the numerous factors that require consideration within a successful drug discovery programme! #MasteringMedChem24
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Our monthly virtual seminar series will hold Next week #Tuesday #8th.Oct. @4-5pm EAT. 🎉 The seminars keep getting more exciting. We shall host #Ene_I._Ette, a distinguished scientist and mentor in the field of Pharmacometrics. How can scientist and regulatory bodies deploy #Pharmacometrics approaches in answering the key regulatory question of product #Bioequivalence? Can we explore the use of pharmacometric approaches, in lieu of laboratory bioequivalence studies? The seminar is such an amazing opportunity to explore these scenarios, and more!
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🔬 BMCS 4th Synthesis in Drug Discovery and Development 2024 💻 Virtual Meeting 📅 June 4-5, 2024 ⏳ Registration Deadline: June 3, 2024 Join this event for a deep dive into the heart of drug discovery and development. This symposium will celebrate the crucial role of synthesis, highlighting the demand for high-quality clinical candidates and the innovative methods used to target less druggable biological targets. 🌟 Why Attend? ◼️ Discover the latest advancements in synthetic methodologies. ◼️ Learn about the introduction of novel bioisosteres. ◼️ Engage with leading experts in the field. ◼️ Don't miss this opportunity to enhance your medicinal chemist's toolbox and network with fellow researchers. 🔗 https://lnkd.in/ebTH8NiX #SDDD24 #DrugDiscovery #MedicinalChemistry #SyntheticMethods #VirtualSymposium
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🔬 BMCS 4th Synthesis in Drug Discovery and Development 2024 💻 Virtual Meeting 📅 June 4-5, 2024 ⏳ Registration Deadline: June 3, 2024 Join this event for a deep dive into the heart of drug discovery and development. This symposium will celebrate the crucial role of synthesis, highlighting the demand for high-quality clinical candidates and the innovative methods used to target less druggable biological targets. 🌟 Why Attend? ◼️ Discover the latest advancements in synthetic methodologies. ◼️ Learn about the introduction of novel bioisosteres. ◼️ Engage with leading experts in the field. ◼️ Don't miss this opportunity to enhance your medicinal chemist's toolbox and network with fellow researchers. 🔗 https://lnkd.in/ebTH8NiX #SDDD24 #DrugDiscovery #MedicinalChemistry #SyntheticMethods #VirtualSymposium
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📢 Join us for the 2nd Joint Webinar ACAMC & LDDD New Advances in Medicinal Chemistry: Bioactive Compounds and Exploitable Targets event on 21st June 2024, GMT+2 (Chieti, Italy). Discover the latest breakthroughs in Medicinal Chemistry and explore new horizons in drug discovery. Connect with experts in the field. Register now!!!! #SimoneCarradori #MedicinalChemistry #DrugDiscovery #webinar #benthamscience
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To find out what Iolanda Micco, our Head of Discovery Chemistry, thinks are the biggest drug discovery stories of 2024 so far, check out her interview at the Oxford Global Discovery Europe 2024 conference in Basel ⬇️ #drugdiscovery #DiscoveryEU24
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This course provides a comprehensive interdisciplinary introduction to the science and process of drug discovery. The course addresses chemical, biological, and business aspects of drug discovery and how it works in the real world from basic laboratory investigation until it reaches the patient in the market. Learn more https://lnkd.in/emy3HtXv
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Just arrived in San Diego for the 19th annual Drug Discovery Chemistry conference. Super excited to be here. On Wednesday morning I’ll be moderating a discussion and Chairing the session on New Degrader Modalities. We’ll be discussing: - Improving potency, modularity and utility of degraders and glues - Discovery and validation of new degrader chemistries and functionality - Exploring constrained macrocycles, cyclic peptides and other degrader modalities - Developing new bivalent and bifunctional molecules #2024drugdiscoverychem
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