Wave Life Sciences’ Post

Important update- first evidence of mHTT selective lowering in humans.

One of my so-called "Big Ideas" that spawned a great biotech -- that precise programming of backbone P-stereochemistry could expand the range and the effectiveness of oligonucleotide therapeutics, has now been convincingly demonstrated in human patients, through the amazing work of Wave Life Sciences. Layering on new chiral backbone P-N chemistry provides further benefits. These are just blow-away results in my opinion. Demonstrating that one can knock down the pathogenic allele in SNP3 Huntington's patients while not only sparing the beneficial "wild-type" allele but indeed increasing its expression is nothing short of remarkable, and paves the way finally for a breakthrough therapeutic intervention in HD. Patients have been waiting, and finally now there is a glimmer of hope. Noteworthy is the observation that the majority of patients show no elevation in neurofilament light (NfL) beyond placebo, and even more importantly, that a statistically significant correlation between mutant HTT lowering and slowing of caudate atrophy was observed for the first time ever in HD. Congratulations to Paul Bolno, Chandra Vargeese, Anne-Marie Li-Kwai-Cheung, and the entire Wave Life Sciences team who overcame so many obstacles to bring this new medicine to HD patients. Sincere gratitude to those patients who participated in this landmark study, which portends a new dawn in genomic medicine. Stereochemistry matters, folks!

We've been exploring some common misconceptions about Mycobacterium testing via qPCR. Here's the next one: ❔Limits of detection for Mycobacterium via PCR are too high 👉 We use 1 litre for testing as opposed to the 100ml aliquots used in culture. This allows us to provide a test with a low limit of detection, equivalent to culture per 100ml for various different species. Keep an eye out for the next misconception about Mycobacterium testing! In the meantime, if you’re looking for a UKAS accredited laboratory offering fast, effective, speciated testing; including M. abscessus, M. avium, M. chimaera, and a pan-species Mycobacterium assay, we can help. Results are validated, comparable to culture and available within 48 hours. Get in touch to find out more ➡️ info@latisscientific.co.uk #mycobacteria #ukasaccredited #qprcr #misconceptions

Proud to be part of this work! A step forward towards the application of #3Rs and the use of #NAMs as alternative methods 🎊 #XETA #endocrinedisruptors #toxicology #ecotoxicology

💡 Interesting paper! https://lnkd.in/d2uqQnK5   This publication defines the mechanistic advantages and limitations of the Xenopus Eleutheroembryonic Thyroid Assay (XETA, OECD TG 248), testing multiple reference chemicals for various mechanisms of action within the thyroid system. The XETA marked a significant milestone as the first eleutheroembryo method validated by the OECD for assessing endocrine activity. The use of the XETA as an alternative to the Amphibian Metamorphosis Assay (AMA, OECD TG 231) has been defined in the ECHA/EFSA guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009 https://lnkd.in/dyGH2Smd In the context of (re)approval of pesticide active substances in Europe, when possible, the submission of a XETA in substitution to an AMA resulted in 10 to 50% reduction of laboratory animals use (% differs from one applicant to another).   CropLife Europe David Du Pasquier, Benoît Salinier, Laurent Lagadic, @Lennart Weltje, Katherine Coady, Alan J. Jones, Oliver Körner, Jessica LaRocca, James Wheeler, Gregory Lemkine, Barbara ROBIN-DUCHESNE #NAMs #endocrinedisruptors #3Rs

Traditionally Arnica montana L. is indicated for treatment of blunt injuries like strains, bruises and contusions that are physiologically accompanied by local inflammation and edema, including activation of the NF-kB pathway and the release of pro-inflammatory prostaglandins and leukotrienes that are produced by cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO). Arnica flowers (A. flos) contain compounds, e.g. sesquiterpene lactones like helenalin or dihydrohelenalin that are known anti-inflammatory compounds. Join Johann Röhrl, PhD, Senior Manager Preclinical Development, WELEDA UK at this 30-mintue workshop taking place at the IPM Congress on Saturday 8 June, to evaluate the anti-inflammatory efficacy of a hydroethanolic extract from A. flos. Register to attend for just £25 per day. See the full workshop programme online at: https://lnkd.in/d85WNzKi #ipmcongress #integrativemedicine #functionalmedicine #lifestylemedicine #personalisedmedicine #arnica #arnicaflower

Register now to follow the most advanced metagenomics assay by NGS!

Block 12 June (13:00-14:15 CEST) in your calendar as we have a great webinar scheduled for you! The AIPPI Committees on Pharma and IP & Genetic Resources and Traditional Knowledge are collaborating for a special Webinar Series. Ready to discuss the aftermath and future prospects of the WIPO Diplomatic Conference on Patent Disclosure Requirement of Genetic Resources in this first session? Register: https://lnkd.in/drR_vUXC #AIPPI #PharmaIP #GeneticResources #TraditionalKnowledge #WebinarSeries

𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗣𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗮𝘁 𝗙𝘂𝗻𝗴𝗮𝗹 𝗠𝘆𝗰𝗼𝗹𝗼𝗴𝘆 𝗨𝗽𝗱𝗮𝘁𝗲 𝟮𝟬𝟮𝟰❗ Join us at the Fungal Mycology Update 2024 Conference in the UK 𝘁𝗵𝗶𝘀 𝘄𝗲𝗲𝗸𝗲𝗻𝗱! Our Application Specialist, Dennis van Tegelen, will be on hand with Serosep Ltd. to provide his firsthand insights and expertise. 𝗞𝗲𝘆 𝗙𝗼𝗰𝘂𝘀 𝗔𝗿𝗲𝗮𝘀: 🔍𝗗𝗶𝗮𝗴𝗻𝗼𝘀𝘁𝗶𝗰 𝗰𝗲𝗿𝘁𝗮𝗶𝗻𝘁𝘆: Explore the future of molecular diagnostics with Dennis as he discusses our IVDR & IVDD Certified PCR Kits, setting a new standard for 𝗿𝗮𝗽𝗶𝗱 𝗮𝗻𝗱 𝗮𝗰𝗰𝘂𝗿𝗮𝘁𝗲 𝗱𝗲𝘁𝗲𝗰𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻 of disease-causing fungus, ensuring diagnostic certainty. 🚫 𝗔𝗻𝘁𝗶𝗳𝘂𝗻𝗴𝗮𝗹 𝗥𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 𝗜𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻: Delve into innovative solutions with Dennis as we simultaneously identify antifungal resistance, addressing a critical concern in the field. Don't miss out on advancements in molecular diagnostics. See you there! 🌐 #mycology2024 #fungalupdate #diagnosticcertainty #fungalresistance

Testbank - Textbook of Diagnostic Microbiology 6th Edition by Connie R. Mahon & Donald C. Lehman - Complete, Elaborated and Latest Test Bank. All Chapters