ScaleReady’s Post

Simplification and standardization of workflows is preferred for applications such as #plasma #proteomics. In our latest application note we describe the development of a complete, fully automated plasma profiling pipeline, seamlessly integrated with high-throughput analysis using the Evosep One and cost-efficient by design. #lcms #massspectrometry #sciencepublication

You are working in #analytical #development and looking for best matching #UHPLC #SEC column(s) for your #monoclonal #antibodies and its #fragments and/or #aggregates? #UPSW column line from Tosoh Bioscience - Separations & Purification offer the best matching solution for your needs and requirements: UP-SW2000 (12,5nm pore size) for analysis of small #proteins, #peptides and #oligonucleotides UP-SW3000 (25 nm pore size) for analysis of #mAbmonomer and #antibodyfragments UP-SW3000-LS (25 nm pore size), optimized for advanced detection methods (#MALS, #LCMS) UP-SW Aggregate (30nm pore size) for analysis of very large proteins and high order #mAbaggregates More information you could find on our web page: https://lnkd.in/eM86WSH8 #chromatographyexperts #TSKgel

📣 Four #𝗕𝗜𝗢𝗣𝗥𝗢𝗗𝗨𝗖𝗧𝗜𝗢𝗡 manufacturers evaluated the 𝗕𝗜𝗢𝗙𝗜𝗥𝗘® 𝗙𝗜𝗟𝗠𝗔𝗥𝗥𝗔𝗬® 𝟮.𝟬 system for mycoplasma detection. The results from these independent evaluators show that the BIOFIRE FILMARRAY 2.0 system is 𝘄𝗲𝗹𝗹-𝘀𝘂𝗶𝘁𝗲𝗱 𝗮𝘀 𝗯𝗼𝘁𝗵 𝗮 𝗿𝗲𝗹𝗲𝗮𝘀𝗲 𝘁𝗲𝘀𝘁 𝗼𝗿 𝗮𝘀 𝗮𝗻 𝗶𝗻-𝗽𝗿𝗼𝗰𝗲𝘀𝘀 𝗰𝗼𝗻𝘁𝗿𝗼𝗹 𝘁𝗲𝘀𝘁 𝗳𝗼𝗿 𝗵𝗶𝗴𝗵-𝗱𝗲𝗻𝘀𝗶𝘁𝘆 𝗖𝗛𝗢 𝗰𝗲𝗹𝗹 𝘀𝗮𝗺𝗽𝗹𝗲𝘀. Everything you need to know is at the link below 👇 #mycoplasma #rapidmicrobiology

From crafting cocktails to advancing life-saving technologies, the blending of solutions quietly shapes our daily lives. In the world of nucleic acids and LNPs, a critical dance unfolds between aqueous and ethanolic solutions. Labs worldwide have mastered the art of combining these elements to create powerful LNP therapeutics. At the core of LNP production are two essential mixing techniques: turbulent and microfluidic mixing. Click the link below to learn more about the differences between these mixing techniques and discover which one is right for you! https://lnkd.in/eNSBNWeQ Author: Michael Hai Luu Nguyen, Ph.D. #biotech #LNP #drugdelivery #therapeutics #nucleicacid

Let's get back to #postertbt! In 2016 we presented our work to assess solvents for the RhE phototox assay... The Reconstructed Human Epidermis (RhE) Phototoxicity assay utilizes a 3D tissue model containing a functional stratum corneum to evaluate potential phototoxicity of test materials. We investigated five solvents, polyethylene glycol (PEG), 5% DMSO in Hanks’ Balanced Salt Solution (HBSS), 5% acetone in HBSS, 5% ethanol, and 1% DMSO in HBSS as is, and also to prepare a 0.02% dilution of chlorpromazine, a photoirritant. Through our work initially presented at SOT in 2016, we demonstrate how potential novel solvents can be evaluated prior to use in phototoxicity assays. This work was further investigated and showcased in a poster presented at SOT in 2024--stay tuned for that work next week.

Introducing UE-SPPS: Total Wash Elimination for Solid Phase Peptide Synthesis. We are thrilled to unveil a revolutionary SPPS process that not only eliminates solvent-intensive washing steps but also paves the way for a more efficient and sustainable peptide synthesis method. With UE-SPPS, you can say goodbye to wasteful and time-consuming washes and hello to a streamlined and productive workflow. Learn more about this groundbreaking technology: https://ow.ly/qSoB50RqNne #PeptideSynthesis #UESPPS #NoWashTechnology #Peptides #GreenTechnology #SustainableChemistry

Mycoplasma poses significant risks to cell lines, biomanufacturing processes, and experimental outcomes. Effective filtration strategies are essential to prevent contamination. Learn how we evaluate our 0.1 µm pore size Stericup® filters for mycoplasma clearance in media preparation.

Separation of the final oligonucleotide product from its closest impurity is challenging, as these impurities are highly related to the full-length product. Download resource guide to see the Agilent complete workflows for oligonucleotide analysis to help you achieve accuracy and optimize speed. https://bit.ly/3TglsBD #oligonucleotidepurity #oligopurity #oligoimpurity

Mycoplasma poses significant risks to cell lines, biomanufacturing processes, and experimental outcomes. Effective filtration strategies are essential to prevent contamination. Learn how we evaluate our 0.1 µm pore size Stericup® filters for mycoplasma clearance in media preparation.

Mycoplasma poses significant risks to cell lines, biomanufacturing processes, and experimental outcomes. Effective filtration strategies are essential to prevent contamination. Learn how we evaluate our 0.1 µm pore size Stericup® filters for mycoplasma clearance in media preparation.