Wellcome Trust’s Post

Removing inflammatory p21 cells improves life span Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, the researchers have demonstrated a treatment that could lengthen life—and vigor—up to the very end. The researchers used two groups of mice. One group received monthly treatments to remove highly inflammatory cells from their tissues; the control group did not. ‘Highly inflammatory cells’ were defined as those actively expressing a specific gene called p21. The team found the monthly treatments extended both the maximum lifespan of mice—the oldest treated mice lived to be 43 months, equivalent to about 130 years old as a human—as well as the average lifespan, so that the average treated mouse lived longer, and healthier, than the average untreated mouse. The researchers are now working on a way to translate their results to humans. If the treatment works as well for humans, it would be equivalent to 8 to 10 additional years of healthy old age. #ScienceMission #sciencenewshighlights https://lnkd.in/gZVZZEyy

🌟 Biology News of the Week! 🧬✨ This week, we’re uncovering some truly fascinating breakthroughs in health and science: 1️⃣ Your skin isn’t just a barrier—it’s a warrior! New research reveals that it has its own immune system, potentially paving the way for needle-free vaccines. 🛡️✨ 2️⃣ Hearts that heal themselves? Scientists have found that some artificial heart patients regenerate heart muscle cells, offering hope for curing heart failure. ❤️🔬 3️⃣ AI meets biology! Researchers have designed virus-inspired nanocages to revolutionize gene therapy and vaccine development. 🧬🤖 🔎 Dive deeper into these discoveries by visiting our website. Tap the link below!💡 https://lnkd.in/dP4fTqnV #biology #biologynews #science #sciencenews #stem #biotech #biotechnology #medicalbreakthrough #skinimmunity #immunesystem #skinhealth #vaccine #microbiology #biochemistry #microbiome #futureofscience #heart #hearthealth #cardiology #cardiac #regenerativemedicine #humanbiology #virus #pathology #genetherapy

The way we think about aging and healthcare is about to change. In this exclusive conversation, I sit down with Dr. Adeel Khan, a global expert in stem cell and regenerative medicine, to break down the science behind longevity, disease prevention, and high-performance health. 🔬 Can stem cells outperform traditional treatments? 🧬 How does gene therapy unlock new possibilities for aging? 💪 Why are top performers turning to regenerative medicine? This isn’t just the future — it’s transforming lives today. Don’t miss this deep dive into the science that’s redefining human longevity. 👉🏻 Watch here: https://lnkd.in/gf4jsgbS #RegenerativeMedicine #StemCells #Biohacking #Longevity #GeneTherapy #HealthOptimization #AntiAging #FutureOfHealth #MedicalInnovation

🎉 Nobel Prize in Physiology or Medicine 2024 Announced! 🎉 We are thrilled to share that Victor Ambros and Gary Ruvkun have been jointly awarded the 2024 #NobelPrize in Physiology or #Medicine for their groundbreaking discovery of #microRNA and its crucial role in post-transcriptional gene regulation.❗️ Their work has unveiled an entirely new layer of gene regulation, essential for understanding how cells function and develop. MicroRNAs are now recognized as key players in ensuring that the correct genes are activated in each cell type—a discovery with profound implications for our understanding of human biology and #disease. 🌱 Why is this important for #biotechnology? The discovery of microRNA has a huge impact on biotechnology, driving innovation in: 👉🏻 gene therapies, 👉🏻 personalized medicine, 👉🏻 agriculture 👉🏻 and many more! By controlling gene expression at a fine level, microRNAs are key to developing targeted treatments for #cancer, autoimmune diseases, and more. In agriculture, it offers new possibilities for enhancing crop resilience and sustainability through genetic regulation. This is a major milestone, setting the stage for future breakthroughs in both human health and biotech industries. 🧬🌍 Congratulations to both laureates for this outstanding achievement! 🧬✨ Read more on: https://lnkd.in/eFU7DuZf #NobelPrize2024 #ScienceBreakthrough #GeneRegulation #biotech

#Genomics | "𝗚𝗲𝗻𝗲 𝗗𝗲𝘀𝗲𝗿𝘁" 𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗲𝘀 𝗘𝗺𝗯𝗿𝘆𝗼𝗻𝗶𝗰 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝗖𝗮𝗿𝗱𝗶𝗮𝗰 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻 | Researchers at the University of Bern, led by Prof. Dr. Marco Osterwalder, in collaboration with University Hospital Bern (Inselspital Stiftung), have identified a "gene desert" that significantly regulates embryonic development and cardiac function. The findings could have profound implications for genetic diagnostics and personalized medicine, potentially aiding in the detection of mutations in gene deserts that can signal risks for birth defects or heart diseases like arrhythmias. 👉 Learn more >> https://lnkd.in/dgfJ_djy 👉 Original publication >> https://lnkd.in/giSbkNVT 🇨🇭 Follow #ScienceSwitzerland for the latest news and emerging trends on Swiss science, technology, education, and innovation >> swissinnovation.org Follow us >> Science-Switzerland #Science | #Education | #Research | #Innovation

On October 7, 2024, it was announced that Victor Ambros and Gary Ruvkun will receive the Nobel Prize in Physiology or Medicine for discovering microRNA and its key role in controlling how genes work. This follows recent Nobel Prizes for major breakthroughs like the mRNA vaccine and the CRISPR gene-editing tool. Ambros and Ruvkun’s discovery, made in 1993, showed that tiny molecules called microRNAs (miRNAs) control how proteins are made in cells by interacting with messenger RNA (mRNA). This revealed a new way genes are regulated in the body. Since then, miRNAs have been recognized as crucial in many biological processes. They either block or break down mRNA, preventing protein production. This regulation is vital for the development and health of organisms. Although miRNAs didn’t lead directly to CRISPR, early research on RNA helped scientists realize the potential of RNA in gene control. This year’s Nobel highlights the growing importance of understanding how genes are controlled, with implications for developing new medical treatments and gene therapies. #rna #science #ip #lifesciences #intellectualproperty #medicine #nobelprize

🌟 2024 Nobel Prize in Physiology or Medicine 🌟 Congratulations to Victor Ambros and Gary Ruvkun for their incredible discovery of microRNA, earning them the 2024 Nobel Prize! 🏆🔬 In simple terms, every cell in our body contains the same genetic material, but different types of cells (like muscle or nerve cells) behave differently because they use different parts of this genetic “instruction manual.” Ambros and Ruvkun discovered that microRNA helps control which genes are “turned on” or “off,” determining how cells develop and function. Their research began with a tiny roundworm, C. elegans, where they found that certain genes were controlled by microRNA rather than proteins, a totally unexpected finding. Over time, they showed that microRNA works by attaching to messenger RNA (which usually helps build proteins) and stopping the process. This discovery has reshaped our understanding of gene regulation in all multicellular organisms, including humans . Their work has had wide-reaching implications, especially in understanding diseases such as cancer and heart disease, where microRNA can play a role in abnormal gene regulation. Researchers are now exploring microRNA-based therapies to treat these conditions. A huge leap for science, and a promising future for medicine! 🌍💊 #NobelPrize #Genetics #microRNA #Innovation #Science #Medicine #Healthcare #Biotech #Research

RESEARCH HIGHLIGHT 🦋🧬🔬 In a new article published in #ScienceDirect Journal researchers assessed #genotypes and #phenotypes from 83 individuals living with RDEB using 🧬 #genetic testing, 📸 standardized photos, and 🏥 clinical outcomes. We are proud to be a funder of this impactful study. Read more below or the the full article at bit.ly/ScienceDirectEBRP GOAL OF STUDY 🔍 🧬 The goal of the study was to understand how various mutations in the COL7A1 gene affect patient outcomes and explore a new way to group patients based on their mutations. OUTCOME 👩⚕️🦋 Certain mutations were associated with more severe disease manifestations. Researchers have identified the need for further validation in larger cohorts, however, the hope is that this can be used to identify patients who are at the highest risk of severe outcomes and provide more personalized support, care and guidance to patients. Stanford University School of Medicine Cincinnati Children'sInstitute of genomics and integrative biology (CSIR) VA PALO ALTO HEALTHCARE SYSTEM

#Molecularmedicine is important for a couple of reasons: It revolutionizes our understanding of diseases (#FutureofMedicine) and allows for the development of more #targetedtreatments (#PrecisionMedicine). Traditionally, medicine focused on symptoms and affected organs. Molecular medicine dives deeper, examining the underlying causes of diseases on a molecular level. This can include things like genetic mutations or malfunctioning proteins. By understanding these mechanisms, researchers can develop more precise treatments aimed at the root cause of the illness, rather than just managing symptoms. This approach has led to significant advancements in various areas. For instance, it has enabled the creation of personalized medicine, where treatments are tailored to an individual's specific genetic makeup (#Genomics #PersonalizedHealthcare). It also plays a crucial role in developing new drugs and gene therapies for diseases that were previously untreatable (#DrugDiscovery #GeneTherapy). Overall, molecular medicine holds immense potential for improving diagnosis, treatment, and prevention of a wide range of diseases. (#HealthcareInnovation #TheFutureisNow)

🎉 𝐁𝐫𝐞𝐚𝐤𝐢𝐧𝐠 𝐍𝐞𝐰𝐬 – 𝟐𝟎𝟐𝟒 𝐍𝐨𝐛𝐞𝐥 𝐏𝐫𝐢𝐳𝐞 𝐢𝐧 𝐏𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐫 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 🏆 The Nobel Assembly at the Karolinska Institutet has awarded this year’s prestigious prize to Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA and its pivotal role in gene regulation. 🧬 🔬 𝐖𝐡𝐲 𝐢𝐬 𝐭𝐡𝐢𝐬 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐫𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐚𝐫𝐲? In every cell of our body, the same set of genes exists, yet different cell types like muscle cells or neurons perform vastly different functions. This year’s laureates uncovered a previously unknown class of tiny RNA molecules called microRNAs that control gene expression at the post-transcriptional level. Their work revealed a fundamental principle governing how cells select specific instructions from our genetic code. 💡 𝐖𝐡𝐚𝐭 𝐦𝐚𝐤𝐞𝐬 𝐦𝐢𝐜𝐫𝐨𝐑𝐍𝐀𝐬 𝐬𝐨 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐭? MicroRNAs represent an entirely new dimension of gene regulation, playing essential roles in how multicellular organisms, including humans, develop and function. Over 1,000 microRNAs have been identified in the human genome, underscoring their critical role in biology. Their discovery not only revolutionized our understanding of gene regulation but also opened new avenues for medical research, impacting areas such as cancer, neurodegenerative diseases, and regenerative medicine. 🌍 Congratulations to these two pioneering scientists for their exceptional contributions to medicine and science! 👏 #NobelPrize #Physiology #Medicine #GeneRegulation #microRNA #Innovation #VictorAmbros #GaryRuvkun #Science #Research #Breakthrough #Biotechnology