📢 Research Highlight: Increased Cancer Risk in Patients with Congenital Heart Disease (CHD) 🫀📈
A significant study explores the association between damaging variants in cancer risk genes and patients with CHD, the most common birth defect. This multicenter case-control study reveals that patients with CHD have a higher frequency of loss-of-function (LoF) variants in cancer risk genes compared to control participants.
Key findings include:
Patients with CHD have a significantly higher frequency of LoF variants in regulatory cancer risk genes.
The highest rates of LoF variants were observed in patients with CHD and extracardiac anomalies or neurodevelopmental delay.
These findings highlight the importance of longitudinal surveillance and early interventions for patients with CHD.
📝 Authors: Sarah U Morton, Akiko Shimamura, Peter Newburger, Alexander (Sasha) Opotowsky, Daniel Quiat, Alexandre Pereira, Sheng Chih Jin, Michelle Gurvitz, martina brueckner, Wendy Chung, Yufeng Shen, DANIEL BERNSTEIN, Bruce D Gelb, Alessandro Giardini, Elizabeth Goldmuntz, Richard W. Kim, RICHARD P. LIFTON, George A Porter, Deepak Srivastava, Martin Tristani-Firouzi, MD, Jane Newburger, J G Seidman, Christine E Seidman
https://lnkd.in/dWDzhtcY
#PhysicianInsights #MedicalPractice #DoctorsUpdate #CHDResearch #CancerRisk #GeneticVariants #MedicalResearch
Wow, this is groundbreaking, The potential to fine-tune immune cells like macrophages could revolutionize treatments for cancer and autoimmune disorders.