Wyss Institute at Harvard University’s Post

Harvard's Wyss Institute has developed an engineered live biotherapeutic product (eLBP) designed to protect the microbiome from the detrimental effects of antibiotics. This innovative technology represents a significant advancement in biotechnology and synthetic biology, aiming to improve gut health and combat antibiotic resistance. The research, which is a breakthrough in the field of bioengineering and medical research, offers promising solutions for maintaining a healthy microbiome during antibiotic treatments. Discover more about this cutting-edge healthcare innovation and its potential to transform the landscape of microbial therapy and probiotics. #Biotechnology #Microbiome #Antibiotics #HealthcareInnovation #MedicalResearch #SyntheticBiology #HarvardResearch #Bioengineering #HealthTech #Probiotics #GutHealth #MicrobialTherapy #LifeSciences #BiomedicalEngineering #AntibioticResistance

GGT is a marker for glutathione depletion in the liver and that elevations in GGT reflect increased exposure to organic xenobiotics that are metabolized in the liver through glutathionylation https://lnkd.in/eAGcN2xz

an other proof for the toxicity of Glyphosate. https://lnkd.in/eQdi7VaK #glyphosate In this work we observed that glyphosate-exposed fish present altered gut microbiomes, which increased their production of SCFAs relative to those from non-exposed animals. High levels of SCFA in the gut may explain their increased peripheral and brain serotonin levels and their increased dopamine levels in the brain (Sherwin et al., 2019), which in turn may relate to their altered anxiety and social behaviors. A similar concatenation of effects may explain similar effects observed in glyphosate-based pesticide-exposed mice (Aitbali et al., 2018). The observed increase in SCFAs in the gut may be a secondary consequence of the substitution of Aeromonas and Undibacterium species by Cetobacterium, among others. Whereas direct evidences on the release of serotonin by EECs or the activation of vagal afferents making synapses on these cells at the intestinal tract have not been provided, it rrepresents the only potential link connecting the increase in the levels of peripheral serotonin and the increase found in dopamine and serotonin levels in the glyphosate treated animals is the MGB axis. Therefore, gut dysbiosis induced by glyphosate is relevant enough to explain most, if not all, symptoms associated to the exposure to this herbicide observed in zebrafish, which may indicate the existence of new neurotoxicological modes of action that have been overlooked up to now.

Table salt NaCl may no longer be just for your taste buds because it has the potential to alter antibiotic effectiveness by impacting the enzymatic functions that underlie bacterial antibiotic resistance. In this truly multidisciplinary and international collaboration with Pablo Catalan from Universidad Carlos III de Madrid and Yuan He from Northwest University, we used acetlylysine to replace Lys73 of carbapenemase OXA-48 which disproved the decades-long belief that "carbapenemases like OXA-48 undergo decarboxylation during catalysis leading to the inhibition". We showed that NaCl altered the antibiotic effectiveness and enzymatic kinetics by promoting a newly discovered inactive acyl-enzyme intermediate, by X-ray protein crystallography, in vitro and in vivo ITC, intrinsic fluorescence, NMR, and mathematical simulation. Yi Jin (金轶) PhD, CChem The University of Manchester #AMR #carbapenemase #antibioticresistance

The concept of fractals offers a compelling lens through which we can observe and interpret patterns in nature, including the behaviors of predators, from large mammals to microscopic entities. For example, just as large predators like big cats and wolves often target weaker individuals in a herd, bacteriophages – viruses that infect bacteria – similarly exhibit selective targeting, possibly based on vulnerabilities in their prey. This parallel suggests a broader principle: the patterns and strategies found in nature, regardless of scale, often reflect underlying fractal-like structures and processes. Therefore, fractal theory could provide valuable insights and predictions about biological interactions and dynamics across different levels of life. #phage #fractaltheory #fractals #commonsense

Our first Open Source Antibiotics paper was really fun to do. Blogged about it at https://lnkd.in/eU_tBr95, paper is at https://lnkd.in/e4NhN24E. Again, lots of inputs from the community, including industry. Project ready for anyone else to carry on. Interested? The other series (number 1) is focussing on mur ligases, where we have new molecules that seem to be inhibiting more than one ligase... #antibiotics #openscience

The finding that OpgH is essential for maintaining the integrity of the bacterial envelope reveals new possibilities for developing effective treatments against #antibioticresistant bacteria. This study illuminates how #bacteria can survive and thrive, but also highlights the pressing need for creative and innovative approaches to #antibiotic #development, as the growing threat of antibiotic resistance poses a significant challenge to public health. Researchers must understand how OpgH and the osmoregulated periplasmic glucans (OPGs) function. That's the challenge.

Essential oils such as thyme and oregano show promising biocontrol capabilities against Fusarium wilt in spinach, with thyme exhibiting the broadest inhibition and both oils consistently demonstrating effective disease reduction rates in seed treatments. This study transitions from in vitro assessments of the inhibitory effects of essential oils on Fusarium strains to in planta experiments with spinach seedlings, highlighting the potential integration of essential oils into disease management strategies for Fusarium wilt. #essentialoils #biocontrol #Fusariumwilt #spinach #diseaseprevention Read more here: https://lnkd.in/eTKP29ye BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

🔬 A new in vivo model of intestinal colonization using Zophobas morio larvae: testing hyperepidemic ESBL- and carbapenemase-producing Escherichia coli clones 🔬   📃 Andrea Endimiani and his team have just published an important paper introducing a new in vivo model of intestinal colonization using Zophobas morio larvae. The work demonstrates that the Zophobas morio larvae model promises to be a feasible and high-throughput approach to study novel gut decolonization strategies for MDR-Ec reducing the number of subsequent confirmatory mammalian experiments in accordance to the #3R approach.   👏 Congratulations to Andrea and his team for this significant contribution to the field!   ➡ Download the full paper here: https://lnkd.in/e-FQXAJH   #nrp79 #3Rs #research

Pleased to share my work published in NAR Nucleic Acids Research. Our paper for the first time highlights the process of miRNA autophagy along with its cognate mRNA. Our research provides new insights into miRNA biology and provides a novel aspect of nutrient-based regulation within Blood cells. Here's the link to the paper :- " https://lnkd.in/dRUMqpKT"