Yousef Alkurdi’s Post

An excellent supplementation with Biotin in weaned pigs leads to a decrease in calprotectin, integrity of goblet cells, inhibition of NF-KB, and regression of colon inflammation

Is it possible that Helicobacter pylori (Gm neg) can exacerbate or cause RA? Infx of gastric epithelial cell line w/ H. pylori upregulated the expression of PAD4 and increased PAD4 activity, leading to Helicobacter pylori-induced citrullination?

Is it possible that Helicobacter pylori (Gm neg) can exacerbate or cause RA? Infx of gastric epithelial cell line w/ H. pylori upregulated the expression of PAD4 and increased PAD4 activity, leading to Helicobacter pylori-induced citrullination?

Common outcome (Glucocerebrosidase Deficiency), different etiologies (biallelic pathogenic variants in GBA1, PSAP, SCARB2) and differences in biochemichal profiles of Gaucher and Gaucher-like phenotypes.

Streptococcus pneumoniae favors tolerance via metabolic adaptation over resistance to circumvent fluoroquinolones https://lnkd.in/gGWqaw3D

𝗠𝗶𝘅𝗶𝗻𝗴 𝗦𝘁𝘂𝗱𝗶𝗲𝘀 Mixing studies are used to investigate abnormal clotting times and differentiate between clotting prolongation due to a factor deficiency or an inhibitor, like lupus anticoagulant. To perform a mixing study, patient plasma is mixed with normal pooled plasma (NPP), and the clotting time is measured. If the clotting time corrects, it suggests a factor deficiency. If not, it indicates the presence of an inhibitor. In factor deficiency, NPP provides enough clotting factors to correct the clotting time. But if an inhibitor is present, it prevents the clotting factors in patient plasma and NPP from functioning, keeping the clotting time prolonged. These results guide further coagulation testing, like specific factor assays or inhibitor assays, helping diagnose and manage clotting disorders effectively. #CoagulationTesting #MixingStudies #ClottingDisorders #FactorDeficiency #InhibitorTesting #Hemostasis #LupusAnticoagulant

IMMUNOLOGIC effects of systemic GLUCOCORTICOIDS, all of which cause immunosuppression→↑Infection & Neoplasm risk •Inhibition of Phospholipase A2 conversion of cell membrane lipids to Arachidonic acid, being the precursor for both Cyclooxygenase−COX enzymes (COX1 & COX2), responsible for the production of Neuronal & Inflammatory cell PROSTAGLANDINS respectively. Their reduced formation→ -↓Pain -↓Temperature (antipyretic) -↓Inflammation •Stabilization of lisosomal & cell membranes→ -↓Cytokine & proteolytic enzyme release •↓Lymphocyte & Eosinophil production knowmedicine.net

Bacteriophages are the most abundant biological entities on Earth, outnumbering bacteria by at least 10 to 1. 🦠 At NexaBiome, we’re focused on leveraging the therapeutic potential of phages to combat bacteria that are increasingly resistant to antibiotics. 🔬 By harnessing the natural specificity and potency of phages, we’re committed to developing innovative treatments that address the escalating challenge of AMR and provide effective solutions for persistent bacterial infections. #Bacteriophage #PhageTherapy #Phage #AMR #Antibiotics

Aerobic training in normal condition increased the expression of hippocampal GFAP (astrocytosis) and Ang-1 proteins, while downregulated the expression of TJ proteins. Under inflammatory disease condition of EAE induction, aerobic training preserved BBB integrity through reducing astrogliosis and Ang-1 as well as reversing EAE-induced TJ proteins downregulation. 

I would like to share a new publication entitled: “Prevalence of Bacteremia and Antimicrobial Resistance Pattern Among Patients in South Lebanon”