Lab Notes Newsletter
Welcome to the August edition of our newsletter!
For 40 years, we’ve helped scientists harness the full potential of biology with next-generation technology. Here we share the latest in automated, end-to-end solutions that span research disciplines to advance scientific discovery and improve the quality of human life worldwide.
NEW BLOG POST: Breaking Barriers and Forging Paths: Inspiring Women in STEM Share their Journey
Molecular Devices is proud to showcase the inspiring stories and honor the remarkable women who have made significant strides in the field of STEM.
We have many inspiring stories of female associates who have consistently defied stereotypes, overcome obstacles, and played a pivotal role in pushing the boundaries of scientific discovery, engineering, and innovation.
By highlighting their remarkable achievements, we aim to inspire future generations of scientists, engineers, and innovators, while fostering an inclusive and diverse environment that empowers women everywhere to continue shaping the future of our industry.
IN THE NEWS: Evaluating the Need for Variable Bandwidth in Microplate Readers
In this Biocompare byline, Caroline Cardonnel, an Application Scientist Supervisor at Molecular Devices, examines the benefits of variable bandwidth readers while also highlighting potential drawbacks. She advises researchers to carefully assess their specific needs, applications, and comfort levels when determining whether variable bandwidth is essential. Additionally, she presents an alternative solution that provides comparable results with reduced risk.
NEW BLOG POST: The Essentials of Parallel Line Analysis in Bioassays: A Comprehensive Guide to PLA Methods and Software Tools
In the regulated environment of pharmaceutical and biotechnology laboratories, the role of Parallel Line Analysis (PLA) cannot be overstated. A crucial analytical method in Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) settings, PLA is a method for evaluating the effect of biological assays. It not only facilitates comparisons between dose-response curves but also serves as a foundation for relative potency calculations.
This article elaborates on the methodologies, statistical tests, and software tools required to carry out effective PLA.
NEW eBOOK: From Lab to Table: Sustainable Solutions for a Growing World
Our latest eBook, Lab to Table: Sustainable Solutions for a Growing World, delves into the science, technology, and real-world applications of this innovative approach to food sustainability. What you’ll learn:
NEW PRODUCT LAUNCH: QPix® Insights Software
Accelerate your research timelines, enhance the efficiency of your workflows, and drive groundbreaking discoveries with QPix® Insights, the latest innovation developed collaboratively by Molecular Devices and IDBS. Powered by Polar.ai, QPix Insights leverages contextual data management and mining to enable advanced data analytics and visualization, empowering informed decisions on optimal colony selection strategies.
NEW SCIENTIFIC POSTER: Single-Cell Dispensing and Screening of hiPSCs for 99% Monoclonality Verification
Our latest research focuses on the utilization of the DispenCell™ Single-Cell Dispenser and CloneSelect® Imager FL in verifying monoclonality of human induced pluripotent stem cells (hiPSCs).
These tools represent a leap forward in ensuring the integrity and purity of cell cultures, crucial for biologics production and therapeutic development.
Download the poster to learn how to:
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NEW ARTICLE: CRISPR expands horizons of genetic engineering
CRISPR technology has revolutionized genetic engineering. Discovered as a part of the bacterial immune system, CRISPR allows for precise, targeted modifications to the genome. By using the CRISPR-associated protein (Cas9) to create double-strand breaks at specific locations in the DNA, scientists can either disrupt a gene or introduce new genetic material through homologous recombination.
However, the potential of CRISPR extends far beyond traditional gene editing.
Here, SelectScience sits down with Dr. Rebecca Kreipke, Field Applications Scientist Manager at Molecular Devices, to learn more about how Molecular Devices’ products can help scientists achieve their CRISPR editing needs.
ON-DEMAND WEBINAR : Advancing Toxicity Research with 3D Tissue Models and Novel Imaging Techniques
In case you missed it, or would just like to re-watch the event, our recent webinar, Advancing Toxicity Research with 3D Tissue Models and Novel Imaging Techniques is now available to view on-demand.
In this webinar, we teamed up with experts from MIMETAS to discuss how pre-clinical in vitro toxicity evaluation of drug compounds can draw meaningful conclusions about safety studies for drug discovery. They also share insights from three comprehensive and reproducible 3D tissue models and their toxic responses to drug and inflammatory mediators using various types of assays.
Key takeaways include:
SCIENTIFIC POSTER: Monitoring of the T-Cell invasion assay using a 3D spheroid model
Despite the boom of CAR T-cell therapies, the discovery of novel immunotherapies that specifically enhance T-cell response against cancer cells remains a challenge
In response to the absence of robust, in vitro models to evaluate these immunotherapies throughout their development, we developed a workflow to easily acquire 3D and 4D T-cell datasets and analyze phenotypic evolution over time.
In this poster, we describe this workcell for the generation of 3D tumor spheroids co-cultured with T-cells as a proof-of-concept model for CAR T assays. Further, we developed an image analysis approach that uses deep learning to accurately segment biological objects of interest and machine learning to quantify the phenotypic changes in the spheroids using only brightfield images.
NEW PODCAST: Advanced Techniques in Toxicity Testing
In our latest podcast with Drug Target Review, we explore advanced toxicity testing methods. Join experts Professor Ruth Roberts and Dr. Oksana Sirenko as they explore innovative assays, human-relevant cell models, and the role of AI in transforming toxicity screening.
Discover how these advancements are shaping the future of drug development.
EVENTS
Sept 18 - 20, 2024 | Boston, MA
Oct 01, 2024 | London, UK
Oct 02-03, 2024 | London, UK