TissueCypher - Barrett's Esophagus

TissueCypher - Barrett's Esophagus

Medical and Diagnostic Laboratories

Pittsburgh, Pennsylvania 1,788 followers

The first precision medicine test for risk stratification of BE patients at risk for progressing to cancer

About us

For patients with Barret’s esophagus (BE), TissueCypher provides a 5-year individual risk of progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). TissueCypher transforms disease management of patients with BE by identifying two important sets of patients: 1. Those at high risk for future progression to cancer or harboring prevalent HGD/EAC; and, 2. Those at low risk of progression who may be able to avoid unnecessary treatment or surveillance. TissueCypher clinical utility and validation has been demonstrated in nine peer-reviewed publications with leading medical centers in the US and Europe, utilizing the largest set of BE progressor patients ever assembled. Overall this body of data demonstrates that a TissueCypher high risk score independently predicts an almost 8-fold increased risk of progression to esophageal cancer (Mayo pooled analysis reference), and has been shows to be the strongest predictor of progression to esophageal cancer. The test utilizes existing tissue biopsies and is indicated for patients diagnosed with Barrett’s esophagus where their tissue pathology has come back as non-dysplastic, indefinite for dysplasia, or low-grade dysplasia. TissueCypher utilizes nine protein biomarkers and 15 digital features of epithelial and stromal cell abnormalities involved in carcinogenesis and nuclear morphology. Tissue slides are stained, imaged, and analyzed using a locked AI-driven algorithm that automatically and objectively provides patients and physicians with an easy to interpret and clinically actionable low, intermediate, and high-risk classification and a projected 5-year risk of progression.

Industry
Medical and Diagnostic Laboratories
Company size
501-1,000 employees
Headquarters
Pittsburgh, Pennsylvania

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