This list was created and kindly provided by user seeyaness. The original can be found here. It reflects LEO's current state as of writing this article. Potential future additions may not be reflected. This list is not intended to be exhaustive.
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[Armor]
Active
+5 Action Points
Agile
+1 Agility
Almost Unbreakable
Quadruples durability
Assassins
-15% damage taken from humans
Atomic Physicist
Fusion Cores last 25% longer
Attentive
+1 Perception
Auto Stim
Automatically use a Stimpak when hit while health is 25% or less, once every 60 seconds
Bolstering
Increased energy and damage resistance the lower your health, up to +35 at 10% health
Bulwark
50% reduced damage from explosions and magnitude of incoming staggers
Cavaliers
-15% damage taken while blocking or sprinting
Chameleon
20% Stealth Ability and become transparent while sneaking and not moving
Charistmatic
+1 Charisma
Cloaking
Being hit in melee generates a Stealth Field for 10 seconds, once per 60 seconds
Cryogenic
10% chance to freeze melee attackers and reduce their damage resistance by 25% for 10 seconds, once every 20 seconds
Cunning
+1 Agility and Perception
Duelists
25% chance to disarm attackers on a successful block
Endurance Runner
Infinite Action points out of combat
Exterminators
+50% Damage against Mirelurks and bugs
Fortifying
+1 Strength and Endurance
Fortunate
+1 Luck
Ghoul Slayers
+50% Damage against ghouls
Hazmat
+25 radiation resistance
Healthy
+5 Health
Hermits
-10% damage taken, +10% weapon damage, +30 Carry Weight and +10 Action Points
Only active when adventuring without a companion
Hunters
-15% damage taken from animals
Incendiary
30% chance to ignite melee attackers for 50 damage, once every 20 seconds
Low Weight
90% reduced weight
Lucky
+2 Luck
Martyrs
30% time dilation for 15 seconds during combat when at 20% or less health
Milk of Human Kindness
+2 Charisma and +1 Luck
Dont tell Strong about it
Mutant Slayers
-15% damage taken from Super Mutants
Nocturnal
Damage and Energy Resistance increase with the night
Up to +20 armor rating and energy resistance
Persevering
+1 Endurance
Piezonucleic Lining
+50% AP regen when taking Radiation Damage
Poisoners
+25 poison resistance
Powered
+5 Action Point Regeneration
Punishing
10% melee damage reflected back on attacker
Rad Powered
Grants +1 Strength per 133 rads, up to +7
Regenerating
Recover 1 health every 2 seconds while not in combat
Resistant
+5 Damage and Energy Resistance
Safecrackers
+100% Sweet-Spot Size while picking locks
Sharp
+1 Charisma and Intelligence
Smart
+1 Intelligence
Sneakers
Become 10% harder to detect while sneaking
Sprinters
+10% movement speed
Strong
+1 Strength
Tesla Coils
Deals 4 Energy Damage per second to nearby enemies
Titans
-15% damage taken while standing and not moving
Troubleshooters
-15% damage taken from robots
Unyielding
+3 to all stats when you are at 25% or less health
VATS Enhanced
-10% VATS Cost
Vanguards
Grants up to +35 Energy and Damage Resistance, the higher your health
Water Breathing
Enables you to breathe underwater
[Weapon]
Active
+10 Action Points
Angering
25% chance to frenzy your opponent on a successful block
Assassins
+50% Damage against humans
Bashers
Bashing damage increased by 40%
Berserkers
Increased Damage the lower your Resistance
+100% at 0 Resistance, -75% at 100+ Resistance
Blazing
25% chance to deal 50 Fire damage on a successful block
Bloodied
Increased damage the lower your health, up to +95% at 5% health
Cavaliers
-15% damage taken while blocking or sprinting
Charged
+10% chance to deal 100 Electrical damage on a successful block
Critically Acclaimed
15% Critical Hit Chance
Affected by crit damage bonuses
Deadeye
30% time dilation for 3 seconds while aiming down sights
Defiant
+100% Damage with the final shot in the magazine
Double
Double ammo capacity
Duelists
25% chance to disarm attackers on a successful block
Enraging
Critical Hits cause target to frenzy, stacking duration
Executioners
50 more damage when your target is below 40% health
Explosive
+15 Explosive Damage
Exterminators
+50% Damage against Mirelurks and bugs
Fast Hands
+50% Reload Speed
Freezing
+10 Cryo Damage (stackable)
Freeze targets and lower damage resistance by 25% for 10 seconds on Critical Hits (not stackable)
Frigid
20% chance to freeze and reduce damage resistance by 25% for 10 seconds when you block an attack
Furious
+15% damage after each consecutive hit on the same target
Ghoul Slayers
+50% Damage against ghouls
Hardy
+1 Endurance
Healthy
+10 Health
Hitmans
+10% damage while aiming down sights
Hunters
+50% Damage against animals
Incendiary
5 points of fire damage per second for 5 seconds, stacking damage
Instigating
+100% damage if the target is at full health
Irradiated
+50 Radiation Damage
Irradiating
50% chance to deal 50 Rads on a successful block
Jakobs
"If it took more than one shot"
+100% Ballistic Damage
-50% Mag Size
Junkies
+15% damage per withdrawal effect you are suffering
Kneecapper
20% chance to cripple the targets leg
Lightweight
90% reduced weight
Lucky Weapon
+100% Critical Damage, +15% critical meter recharge
Ma Li-Wans
"Is shooting bullets just not cool enough for you?"
+100% Energy Damage
-50% Cell Charge
Marksmans
+100% base range and 50% improved base accuracy and recoil
Medics
Heal targets for 10 health and 200 radiation
Mutant Slayers
+50% Damage against super mutans
Never Ending
Unlimited ammo capacity
Nimble
+75% movement speed while aiming down sights
Nocturnal
Increased damage at nighttime, up to +100%
Decreased damage at daytime, up to -66%
Overpowering
40% more power attack damage
Penetrating
30% penetration of damage and energy resistance
Plasma Infused
+10 energy damage
Can turn enemies into goo
Poisoners
+3 poison damage per second for 10 seconds, stacking damage
Powerful
+25% Damage
Protective
Take 40% less damage while power attacking
Quad
Quadruple ammo capacity
Stackable with other instances of the same effect
Quickdraw
-25% VATS Cost
Rapid
25% faster fire rate, 15% faster reload
Relentless
Refills your Action Points on a Critical Hit
Resilient
+150 damage resistance while reloading
Resolute
30% time dilation for 3 seconds when chambering the final round in the magazine
Riposting
Reflects 50% of melee damage back while blocking
Sentinels
-15% damage taken while standing and not moving
Staggering
+50% chance to stagger on hit with melee weapons, +30% with semi-auto guns, +5% with automatic guns
Stalkers
+100% VATS accuracy if not yet in combat
Double AP cost
Steadfast
+50 damage resistance while aiming
Suppressors
Reduce your targets damage output by 20% for 3s
Swift
+1 Agility
Troubleshooters
+50% Damage against robots
Two-Shot
Double projectile count
+100% Damage, +100% Recoil, +150% Spread
VATS Enhanced [Gun]
+33% VATS Accuracy, -25% VATS Cost
The latter is stackable, the former is not
VATS Enhanced [Melee]
-40% VATS Cost
Vampires
Grain brief health regeneration when you hit an enemy
+5 health over 2 seconds
Vigilant
+1 Perception
Vigorous
+1 Strength
Violent
+25% damage and limb damage, +200% recoil
Wounding
3 points of bleed damage per second for 5 seconds
Stacking unresistable/armor-penetrating damage
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