There are three different files that all have their own script and you only need to install one based on your preference.
Pandemonium.esp : Frenzies all NPCs
TheyHateMe.esp : Makes all NPCs aggressive toward the player only
HuntDownTheCourier.esp : NPCs are aggressive toward the player and sneaking is impossible
With the last two files, there's a bug that makes all enemies invisible on the compass.
Pandemonium takes effect after Doc Mitchell's, you don't need to install before or after any quest.
This mod makes it impossible to complete the campaign and most side quests.