Please follow this guideline when posting bug reports. Here is what I need from you:

First off, go check your log file at Documents\My Games\Skyrim Special Edition\SKSE\AlchemyOfTime.log,
it might be something obvious. Maybe your presets are incorrectly configured.

After encountering a problem, store the log somewhere if possible, and try to reproduce it.
If it is reproducible, great, grab the debug file under MISC section and do it again. I will need the log file from the debug version.
Then open a bug report and tell me exactly what happened how it happened and whether it is reproducible.
Send me your log files and crash reports and whatnot via pastebin or similar. Tell me also your game version if not included in crash log.
From then on I will do my best to help you.